Sökning: WFRF:(Joniau Steven) >
Intratunical inject...
Intratunical injection of autologous adipose stromal vascular fraction reduces collagen III expression in a rat model of chronic penile fibrosis
-
- Hakim, Lukman (författare)
- Dr. Soetomo Hospital,Catholic University of Leuven,Arilangga University,Univ Leuven, Belgium; Airlangga Univ, Indonesia
-
- Fiorenzo, Salvatore (författare)
- University of Palermo,Univ Palermo, Italy
-
- Hedlund, Petter (författare)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Avdelningen för läkemedelsforskning,Region Östergötland, Klinisk farmakologi,Lund Univ, Sweden
-
visa fler...
-
- Montorsi, Francesco (författare)
- San Raffaele Hospital,IRCCS, Italy
-
- Bivalacqua, Trinity J. (författare)
- Johns Hopkins Hospital,Johns Hopkins Med Inst, MD 21205 USA
-
- De Ridder, Dirk (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
-
- Weyne, Emmanuel (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
-
- Ralph, David (författare)
- University College London Hospital,Univ Coll London Hosp UCLH, England
-
- Garaffa, Giulio (författare)
- University College London Hospital,Univ Coll London Hosp UCLH, England
-
- Muneer, Asif (författare)
- University College London Hospital,Univ Coll London Hosp, England; Univ Coll London Hosp, England
-
- Joniau, Steven (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
-
- Albersen, Maarten (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
-
- Castiglione, Fabio (författare)
- San Raffaele Hospital,Catholic University of Leuven,University College London Hospital,Univ Leuven, Belgium; IRCCS, Italy; Univ Coll London Hosp UCLH, England
-
visa färre...
-
Dr Soetomo Hospital Catholic University of Leuven (creator_code:org_t)
-
- 2019-04-15
- 2019
- Engelska.
-
Ingår i: International Journal of Impotence Research. - : Springer Science and Business Media LLC. - 0955-9930 .- 1476-5489.
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
http://repository.un...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Previous studies have shown that the injection of adipose stem cells and stromal vascular fraction(SVF) into the tunica albuginea (TA) during the inflammatory phase in a rat model of Peyronie’s disease(PD) prevented the development of TA fibrosis. Our aim was to investigate whether local injection of SVF can reduce established fibrosis in a rat model of chronic phase of PD. Eighteen-male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (PD) and PD treated with SVF(PD-SVF). Sham rats underwent 2 injections of vehicle into the TA one month apart. PD rats underwent TGF-β1 injection and injection of vehicle one month later. PD-SVF rats underwent TGF-β1 injection followed by SVF (1-million cells) one month later. One month after the last treatment, the animals, n = 6 rats per group, underwent measurement of intracorporal and mean arterial pressure during electrostimulation of the cavernous nerve. Following euthanasia, penises were harvested for in-vitro study. Erectile function was not statistically significantly different between groups. PD animals developed subtunical areas of fibrosis and elastosis with upregulation of collagen III protein. These fibrotic changes were reversed after injection of SVF. We provide evidence that local injection of SVF reverses TA fibrosis in a rat model of chronic phase of PD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hakim, Lukman
-
Fiorenzo, Salvat ...
-
Hedlund, Petter
-
Montorsi, France ...
-
Bivalacqua, Trin ...
-
De Ridder, Dirk
-
visa fler...
-
Weyne, Emmanuel
-
Ralph, David
-
Garaffa, Giulio
-
Muneer, Asif
-
Joniau, Steven
-
Albersen, Maarte ...
-
Castiglione, Fab ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Lunds universitet
-
Linköpings universitet