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Long-term consequen...
Long-term consequences of bilateral cavernous crush injury in normal and diabetic rats : a functional study
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- Castiglione, Fabio (författare)
- University College London Hospital,San Raffaele Hospital,University College London,Univ Coll London Hosp, England; UCL, England; IRCCS Osped San Raffaele, Italy
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- Albersen, Maarten (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
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- Fiorenzo, Salvatore (författare)
- University of Palermo,Univ Palermo, Italy
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- Hedlund, Petter (författare)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Region Östergötland, Klinisk farmakologi,Lund Univ, Sweden
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- Cakir, Omer Onur (författare)
- University College London Hospital,Univ Coll London Hosp, England
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- Pavone, Carlo (författare)
- University of Palermo,Univ Palermo, Italy
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- Alnajjar, Hussain M. (författare)
- University College London Hospital,Univ Coll London Hosp, England
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- Joniau, Steven (författare)
- Catholic University of Leuven,Univ Leuven, Belgium
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- Muneer, Asif (författare)
- University College London,University College London Hospital,Univ Coll London Hosp, England; UCL, England; Univ Coll London Hosp, England; Univ Coll London Hosp, England
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- Kluth, Luis A. (författare)
- Hospital Universitario Marqués de Valdecilla
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- Campos-Juanatey, Felix (författare)
- University Hospital Frankfurt
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- Cocci, Andrea (författare)
- University of Florence
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- Rosenbaum, Clemens M. (författare)
- University Medical Center Hamburg-Eppendorf
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- Vetterlein, Malte W. (författare)
- University Medical Center Hamburg-Eppendorf
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- Fes, Enrique (författare)
- Hospital Can Misses
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- Adamowicz, Jan (författare)
- Nicolaus Copernicus University
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(creator_code:org_t)
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- 2021-10-05
- 2022
- Engelska.
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Ingår i: International Journal of Impotence Research. - : Springer Science and Business Media LLC. - 0955-9930 .- 1476-5489. ; 34:8, s. 781-785
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- A recent statement from the European-Society-for-Sexual-Medicine has highlighted the limitations of using the rat model for nerve-sparing prostatectomy. The use of young rats with no comorbidities and the early evaluation of the erectile function (EF) are deemed a source of bias. Our aim was to evaluate the long-term consequences in EF of bilateral nerve cavernous crush- injury (BNCI) in type 1 diabetic (DM) rats 30-male/12-week-old rats were divided into four groups: Sham, BNCI, DM, and BNCI + DM. Sham group underwent an intraperitoneal injection (IP) of saline solution and after 1 month underwent a sham laparotomy. BNCI underwent an IP of saline solution and after 1 month to BNCI. DM underwent an IP of 60 mg/kg-1-streptozotocin (STZ) and after 1 month to a sham laparotomy. BNCI + DM underwent an IP of 60 mg/kg-1-STZ and after 1 month to BNCI. After 5 months from the induction of diabetes, all rats underwent measurement of intracorporeal pressure (ICP) and mean arterial pressure (MAP) during CN-electrostimulation. Multiple groups were compared using Kruskal–Wallis one-way analysis of variance followed by Mann–Whitney U test for post hoc comparisons. Blood glucose-level was higher (p < 0.05) in the groups with DM and BNCI + DM. After 5-months, DM and BNCI + DM also showed a lower weight compared to other groups (p < 0.05). No differences were noted in ICP/MAP between the sham and BNCI. BNCI + DM showed lower ICP/MAP compared to all the groups (p < 0.05). DM Showed lower ICP/MAP compared to Sham and BNCI (p < 0.05). BNCI in rats without comorbidities did not induce long-term erectile dysfunction (ED) suggesting a spontaneous EF recovery. BNCI in DM induced long-term ED. The results of previous short-term studies can only provide evidence on the time to recovery of spontaneous EF as to the actual EF recovery rate.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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Castiglione, Fab ...
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Albersen, Maarte ...
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Fiorenzo, Salvat ...
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Hedlund, Petter
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Cakir, Omer Onur
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Pavone, Carlo
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Alnajjar, Hussai ...
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Joniau, Steven
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Muneer, Asif
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Kluth, Luis A.
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Campos-Juanatey, ...
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Cocci, Andrea
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Rosenbaum, Cleme ...
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Vetterlein, Malt ...
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Fes, Enrique
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Adamowicz, Jan
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MEDICIN OCH HÄLS ...
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Kirurgi
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