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A new tool to assess Clinical Diversity In Meta-analyses (CDIM) of interventions

Barbateskovic, Marija (author)
Copenhagen University Hospital,University of Copenhagen
Koster, Thijs M. (author)
University of Groningen,University Medical Center Groningen
Eck, Ruben J. (author)
University Medical Center Groningen,University of Groningen
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Maagaard, Mathias (author)
Karolinska Institutet
Afshari, Arash (author)
Copenhagen University Hospital,University of Copenhagen
Blokzijl, Fredrike (author)
University Medical Center Groningen,University of Groningen
Cronhjort, Maria (author)
Karolinska Institute,Stockholm South General Hospital
Dieperink, Willem (author)
University of Groningen,University Medical Center Groningen
Fabritius, Maria L. (author)
University of Copenhagen,Copenhagen University Hospital
Feinberg, Josh (author)
Holbæk Hospital
French, Craig (author)
University of Melbourne
Gareb, Barzi (author)
University of Groningen,University Medical Center Groningen
Geisler, Anja (author)
Zealand University Hospital
Granholm, Anders (author)
University of Copenhagen
Hiemstra, Bart (author)
University Medical Center Groningen,University of Groningen
Hu, Ruixue (author)
China Academy of Chinese Medical Sciences
Imberger, Georgina (author)
Sunshine Hospital, St Albans,University of Melbourne
Jensen, Bente T. (author)
Aarhus University Hospital
Jonsson, Andreas B. (author)
Copenhagen University Hospital,University of Copenhagen
Karam, Oliver (author)
Children’s Hospital of Richmond,Virginia Commonwealth University
Kong, De Zhao (author)
Liaoning University of Traditional Chinese Medicine
Korang, Steven K. (author)
Copenhagen University Hospital
Koster, Geert (author)
University of Groningen,University Medical Center Groningen
Lai, Baoyong (author)
Beijing University of Chinese Medicine Third Affiliated Hospital
Liang, Ning (author)
China Academy of Chinese Medical Sciences
Lundstrøm, Lars H. (author)
Hillerod Hospital
Marker, Søren (author)
University of Copenhagen,Copenhagen University Hospital
Meyhoff, Tine S. (author)
Copenhagen University Hospital,University of Copenhagen
Nielsen, Emil E. (author)
Holbæk Hospital
Nørskov, Anders K. (author)
Copenhagen University Hospital
Munch, Marie W. (author)
University of Copenhagen
Risom, Emilie C. (author)
Copenhagen University Hospital
Rygård, Sofie L. (author)
Copenhagen University Hospital,University of Copenhagen
Safi, Sanam (author)
Copenhagen University Hospital
Sethi, Naqash (author)
Copenhagen University Hospital
Sjövall, Fredrik (author)
Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Skåne University Hospital
Lauridsen, Susanne V. (author)
University of Copenhagen,Frederiksberg Hospital,Copenhagen University Hospital
van Bakelen, Nico (author)
University Medical Center Groningen,University of Groningen
Volbeda, Meint (author)
University of Groningen,University Medical Center Groningen
van der Horst, Iwan C.C. (author)
Maastricht University Medical Centre,Maastricht University
Gluud, Christian (author)
Copenhagen University Hospital
Perner, Anders (author)
Copenhagen University Hospital,University of Copenhagen
Møller, Morten H. (author)
Copenhagen University Hospital,University of Copenhagen
Keus, Eric (author)
University Medical Center Groningen,University of Groningen
Wetterslev, Jørn (author)
Copenhagen University Hospital,University of Copenhagen
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 (creator_code:org_t)
Elsevier BV, 2021
2021
English 13 s.
In: Journal of Clinical Epidemiology. - : Elsevier BV. - 0895-4356 .- 1878-5921. ; 135, s. 29-41
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Objective: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions. Study design and setting: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreement in three groups. Results: CDIM measures clinical diversity on a scale that includes four domains with 11 items overall: setting (time of conduct/country development status/units type); population (age, sex, patient inclusion criteria/baseline disease severity, comorbidities); interventions (intervention intensity/strength/duration of intervention, timing, control intervention, cointerventions); and outcome (definition of outcome, timing of outcome assessment). The CDIM is completed in two steps: first two authors independently assess clinical diversity in the four domains. Second, after agreeing upon scores of individual items a consensus score is achieved. Interrater scale reliability and agreement ranged from moderate to almost perfect depending on the type of raters. Conclusion: CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Diversity
Evidence
Heterogeneity
Meta-analysis
Quality
Systematic review
Tool

Publication and Content Type

art (subject category)
ref (subject category)

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