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1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Gorski, Mathias (author)
van der Most, Peter J (author)
Teumer, Alexander (author)
show more...
Chu, Audrey Y (author)
Li, Man (author)
Mijatovic, Vladan (author)
Nolte, Ilja M (author)
Cocca, Massimiliano (author)
Taliun, Daniel (author)
Gomez, Felicia (author)
Li, Yong (author)
Tayo, Bamidele (author)
Tin, Adrienne (author)
Feitosa, Mary F (author)
Aspelund, Thor (author)
Attia, John (author)
Biffar, Reiner (author)
Bochud, Murielle (author)
Boerwinkle, Eric (author)
Borecki, Ingrid (author)
Bottinger, Erwin P (author)
Chen, Ming-Huei (author)
Chouraki, Vincent (author)
Ciullo, Marina (author)
Coresh, Josef (author)
Cornelis, Marilyn C (author)
Curhan, Gary C (author)
d'Adamo, Adamo Pio (author)
Dehghan, Abbas (author)
Dengler, Laura (author)
Ding, Jingzhong (author)
Eiriksdottir, Gudny (author)
Endlich, Karlhans (author)
Enroth, Stefan, 1976- (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Esko, Tõnu (author)
Franco, Oscar H (author)
Gasparini, Paolo (author)
Gieger, Christian (author)
Girotto, Giorgia (author)
Gottesman, Omri (author)
Gudnason, Vilmundur (author)
Gyllensten, Ulf (author)
Hancock, Stephen J (author)
Harris, Tamara B (author)
Helmer, Catherine (author)
Höllerer, Simon (author)
Hofer, Edith (author)
Hofman, Albert (author)
Holliday, Elizabeth G (author)
Homuth, Georg (author)
Hu, Frank B (author)
Huth, Cornelia (author)
Hutri-Kähönen, Nina (author)
Hwang, Shih-Jen (author)
Imboden, Medea (author)
Johansson, Åsa (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Kähönen, Mika (author)
König, Wolfgang (author)
Kramer, Holly (author)
Krämer, Bernhard K (author)
Kumar, Ashish (author)
Kutalik, Zoltan (author)
Lambert, Jean-Charles (author)
Launer, Lenore J (author)
Lehtimäki, Terho (author)
de Borst, Martin (author)
Navis, Gerjan (author)
Swertz, Morris (author)
Liu, Yongmei (author)
Lohman, Kurt (author)
Loos, Ruth J F (author)
Lu, Yingchang (author)
Lyytikäinen, Leo-Pekka (author)
McEvoy, Mark A (author)
Meisinger, Christa (author)
Meitinger, Thomas (author)
Metspalu, Andres (author)
Metzger, Marie (author)
Mihailov, Evelin (author)
Mitchell, Paul (author)
Nauck, Matthias (author)
Oldehinkel, Albertine J (author)
Olden, Matthias (author)
Wjh Penninx, Brenda (author)
Pistis, Giorgio (author)
Pramstaller, Peter P (author)
Probst-Hensch, Nicole (author)
Raitakari, Olli T (author)
Rettig, Rainer (author)
Ridker, Paul M (author)
Rivadeneira, Fernando (author)
Robino, Antonietta (author)
Rosas, Sylvia E (author)
Ruderfer, Douglas (author)
Ruggiero, Daniela (author)
Saba, Yasaman (author)
Sala, Cinzia (author)
Schmidt, Helena (author)
Schmidt, Reinhold (author)
Scott, Rodney J (author)
Sedaghat, Sanaz (author)
Smith, Albert V (author)
Sorice, Rossella (author)
Stengel, Benedicte (author)
Stracke, Sylvia (author)
Strauch, Konstantin (author)
Toniolo, Daniela (author)
Uitterlinden, Andre G (author)
Ulivi, Sheila (author)
Viikari, Jorma S (author)
Völker, Uwe (author)
Vollenweider, Peter (author)
Völzke, Henry (author)
Vuckovic, Dragana (author)
Waldenberger, Melanie (author)
Jin Wang, Jie (author)
Yang, Qiong (author)
Chasman, Daniel I (author)
Tromp, Gerard (author)
Snieder, Harold (author)
Heid, Iris M (author)
Fox, Caroline S (author)
Köttgen, Anna (author)
Pattaro, Cristian (author)
Böger, Carsten A (author)
Fuchsberger, Christian (author)
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 (creator_code:org_t)
2017-04-28
2017
English.
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.

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By the author/editor
Gorski, Mathias
van der Most, Pe ...
Teumer, Alexande ...
Chu, Audrey Y
Li, Man
Mijatovic, Vlada ...
show more...
Nolte, Ilja M
Cocca, Massimili ...
Taliun, Daniel
Gomez, Felicia
Li, Yong
Tayo, Bamidele
Tin, Adrienne
Feitosa, Mary F
Aspelund, Thor
Attia, John
Biffar, Reiner
Bochud, Murielle
Boerwinkle, Eric
Borecki, Ingrid
Bottinger, Erwin ...
Chen, Ming-Huei
Chouraki, Vincen ...
Ciullo, Marina
Coresh, Josef
Cornelis, Marily ...
Curhan, Gary C
d'Adamo, Adamo P ...
Dehghan, Abbas
Dengler, Laura
Ding, Jingzhong
Eiriksdottir, Gu ...
Endlich, Karlhan ...
Enroth, Stefan, ...
Esko, Tõnu
Franco, Oscar H
Gasparini, Paolo
Gieger, Christia ...
Girotto, Giorgia
Gottesman, Omri
Gudnason, Vilmun ...
Gyllensten, Ulf
Hancock, Stephen ...
Harris, Tamara B
Helmer, Catherin ...
Höllerer, Simon
Hofer, Edith
Hofman, Albert
Holliday, Elizab ...
Homuth, Georg
Hu, Frank B
Huth, Cornelia
Hutri-Kähönen, N ...
Hwang, Shih-Jen
Imboden, Medea
Johansson, Åsa
Kähönen, Mika
König, Wolfgang
Kramer, Holly
Krämer, Bernhard ...
Kumar, Ashish
Kutalik, Zoltan
Lambert, Jean-Ch ...
Launer, Lenore J
Lehtimäki, Terho
de Borst, Martin
Navis, Gerjan
Swertz, Morris
Liu, Yongmei
Lohman, Kurt
Loos, Ruth J F
Lu, Yingchang
Lyytikäinen, Leo ...
McEvoy, Mark A
Meisinger, Chris ...
Meitinger, Thoma ...
Metspalu, Andres
Metzger, Marie
Mihailov, Evelin
Mitchell, Paul
Nauck, Matthias
Oldehinkel, Albe ...
Olden, Matthias
Wjh Penninx, Bre ...
Pistis, Giorgio
Pramstaller, Pet ...
Probst-Hensch, N ...
Raitakari, Olli ...
Rettig, Rainer
Ridker, Paul M
Rivadeneira, Fer ...
Robino, Antoniet ...
Rosas, Sylvia E
Ruderfer, Dougla ...
Ruggiero, Daniel ...
Saba, Yasaman
Sala, Cinzia
Schmidt, Helena
Schmidt, Reinhol ...
Scott, Rodney J
Sedaghat, Sanaz
Smith, Albert V
Sorice, Rossella
Stengel, Benedic ...
Stracke, Sylvia
Strauch, Konstan ...
Toniolo, Daniela
Uitterlinden, An ...
Ulivi, Sheila
Viikari, Jorma S
Völker, Uwe
Vollenweider, Pe ...
Völzke, Henry
Vuckovic, Dragan ...
Waldenberger, Me ...
Jin Wang, Jie
Yang, Qiong
Chasman, Daniel ...
Tromp, Gerard
Snieder, Harold
Heid, Iris M
Fox, Caroline S
Köttgen, Anna
Pattaro, Cristia ...
Böger, Carsten A
Fuchsberger, Chr ...
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Articles in the publication
Scientific Repor ...
By the university
Uppsala University
Karolinska Institutet

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