Tyck till om SwePub Sök
här!
Sökning: onr:"swepub:oai:DiVA.org:liu-188603" >
Molecular epidemiol...
Molecular epidemiology of community- and hospital-associated Clostridioides difficile infections in Jönköping, Sweden, October 2017-March 2018
-
- Enkirch, Theresa (författare)
- Publ Hlth Agcy Sweden, Sweden; European Ctr Dis Prevent & Control ECDC, Sweden
-
- Mernelius, Sara (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Lab Med, Sweden
-
- Magnusson, Cecilia, 1971- (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Dept Infect Dis, Sweden
-
visa fler...
-
- Kühlmann-Berenzon, Sharon (författare)
- Publ Hlth Agcy Sweden, Sweden
-
- Bengnér, Malin (författare)
- Off Control Communicable Dis, Sweden
-
- Åkerlund, Thomas (författare)
- Publ Hlth Agcy Sweden, Sweden
-
- Rizzardi, Kristina (författare)
- Publ Hlth Agcy Sweden, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2022-09-06
- 2022
- Engelska.
-
Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 130:11, s. 661-670
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Clostridioides difficile infections (CDIs) in Sweden are mostly hospital-associated (HA) with limited knowledge regarding community-associated (CA) infections. Here, we investigated the molecular epidemiology of clinical isolates of CA-CDI and HA-CDI in a Swedish county. Data and isolates (n = 156) of CDI patients (n = 122) from Jonkoping county, October 2017-March 2018, were collected and classified as CA (without previous hospital care or onset <= 2 days after admission or >12 weeks after discharge from hospital) or HA (onset >3 days after hospital admission or within 4 weeks after discharge). Molecular characterization of isolates included PCR ribotyping (n = 156 isolates) and whole genome sequencing with single nucleotide polymorphisms (SNP) analysis (n = 53 isolates). We classified 47 patients (39%) as CA-CDI and 75 (61%) as HA-CDI. Between CA-CDI and HA-CDI patients, we observed no statistically significant differences regarding gender, age, 30-day mortality or recurrence. Ribotype 005 (RR 3.1; 95% CI: 1.79-5.24) and 020 (RR 2.5; 95% CI: 1.31-4.63) were significantly associated with CA-CDI. SNP analysis identified seven clusters (0-2 SNP difference) involving 17/53 isolates of both CA-CDI and HA-CDI. Molecular epidemiology differed between CA-CDI and HA-CDI and WGS analysis suggests transmission of CDI within and between hospitals and communities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Bacteriology; clinical microbiology; Clostridioides difficile; community-associated infections; enhanced surveillance; hospital-associated infections; molecular microbiology; whole genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas