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Exposure to bacteri...
Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma : a nested case-control study
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- Fedirko, Veronika (författare)
- Emory University
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- Tran, Hao Quang (författare)
- Georgia State University
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- Gewirtz, Andrew T (författare)
- Georgia State University
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens
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- Aleksandrova, Krasimira (författare)
- German Institute of Human Nutrition
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Carbonnel, Franck (författare)
- University of Paris-Saclay
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- Boutron-Ruault, Marie-Christine (författare)
- University of Paris-Saclay
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- Severi, Gianluca (författare)
- University of Paris-Saclay
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition,University of Malaya
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- Bamia, Christina (författare)
- National and Kapodistrian University of Athens
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- Lagiou, Pagona (författare)
- National and Kapodistrian University of Athens
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Naccarati, Alessio (författare)
- Human Genetics Foundation (HuGeF)
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- Peeters, Petra H (författare)
- University Medical Center Utrecht
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Bueno-de-Mesquita, H B (författare)
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute
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- Castaño, José María Huerta (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Barricarte, Aurelio (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Sánchez, María-José (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro, Miren (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Quirós, J Ramón (författare)
- Public Health Directorate
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology
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- Sjöberg, Klas (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Hemmingsson, Oskar (författare)
- Department of Surgical and Perioperative Sciences, Kirurgcentrum, Norrlands Universitetssjukhus, Umeå, Sweden,Norrland University Hospital
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- Werner, Mårten (författare)
- Department of Medicine Sections for Hepatology and Gastroenterology, Umeå University Hospital, SE-90185 Umeå, Sweden,Norrland University Hospital
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- Bradbury, Kathryn E (författare)
- University of Oxford
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Wareham, Nick (författare)
- University of Cambridge
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- Tsilidis, Konstantinos K (författare)
- University of Ioannina
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- Aune, Dagfinn (författare)
- Imperial College London
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (författare)
- Imperial College London
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2017-04-04
- 2017
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central. - 1741-7015. ; 72:15
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://bmcmedicine....
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression.RESULTS: = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses.CONCLUSIONS: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Endotoxins
- Flagellin
- Hepatocellular carcinoma
- Lipopolysaccharide
- Prospective studies
- Endotoxins
- Flagellin
- Hepatocellular carcinoma
- Lipopolysaccharide
- Prospective studies
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Fedirko, Veronik ...
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Tran, Hao Quang
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Gewirtz, Andrew ...
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Stepien, Magdale ...
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Aleksandrova, Kr ...
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Olsen, Anja
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Tjønneland, Anne
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Overvad, Kim
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Severi, Gianluca
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Kühn, Tilman
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Kaaks, Rudolf
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Boeing, Heiner
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Bamia, Christina
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Lagiou, Pagona
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Grioni, Sara
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Panico, Salvator ...
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Palli, Domenico
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Tumino, Rosario
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Naccarati, Aless ...
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Peeters, Petra H
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Bueno-de-Mesquit ...
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Weiderpass, Elis ...
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Castaño, José Ma ...
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Barricarte, Aure ...
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Sánchez, María-J ...
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Dorronsoro, Mire ...
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Quirós, J Ramón
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Agudo, Antonio
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Sjöberg, Klas
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Ohlsson, Bodil
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Hemmingsson, Osk ...
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Werner, Mårten
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Bradbury, Kathry ...
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Khaw, Kay-Tee
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Wareham, Nick
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Tsilidis, Konsta ...
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Aune, Dagfinn
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Scalbert, August ...
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Romieu, Isabelle
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Riboli, Elio
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Jenab, Mazda
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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BMC Medicine
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet