Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium

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Quantification of the smoking-associated cancer risk with rate advancement periods : meta-analysis of individual participant data from cohorts of the CHANCES consortium

Ordóñez-Mena, José Manuel (författare): Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

Schöttker, Ben (författare): Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

Mons, Ute (författare): German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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Jenab, Mazda (författare): Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France.

Freisling, Heinz (författare): Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France.

Bueno-de-Mesquita, Bas (författare): Natl Inst Publ Hlth & Environm RIVM, Dept Chron Dis, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Div Epidemiol & Biostat, London, England.;Univ Malaya, Dept Social Prevent Med, Fac Med, Kuala Lumpur, Malaysia.

O'Doherty, Mark G. (författare): Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.

Scott, Angela (författare): Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.

Kee, Frank (författare): Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.

Stricker, Bruno H. (författare): Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.

Hofman, Albert (författare): Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.

de Keyser, Catherine E. (författare): Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.

Ruiter, Rikje (författare): Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.

Söderberg, Stefan (författare): Umeå universitet,Kardiologi,Heart Center,Umea Univ, Dept Publ Hlth & Clin Med, Cardiol & Heart Ctr, Umea, Sweden.

Jousilahti, Pekka (författare): Natl Inst Hlth & Welf THL, Helsinki, Finland.

Kuulasmaa, Kari (författare): Natl Inst Hlth & Welf THL, Helsinki, Finland.

Freedman, Neal D. (författare): NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.

Wilsgaard, Tom (författare): UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.

de Groot, Lisette C. P. G. M. (författare): Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.

Kampman, Ellen (författare): Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.

Håkansson, Niclas (författare): Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.

Orsini, Nicola (författare): Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.

Wolk, Alicja (författare): Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.

Nilsson, Lena Maria (författare): Umeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum),Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Arctic Res Ctr, Umea, Sweden.;Umea Univ, Arcum, Arctic Res Ctr, Umea, Sweden.

Tjønneland, Anne (författare): Danish Canc Soc, Res Ctr, Diet Genes & Environm, Copenhagen, Denmark.

Pająk, Andrzej (författare): Jagiellonian Univ, Coll Med, Fac Hlth Sci, Krakow, Poland.

Malyutina, Sofia (författare): Inst Internal & Prevent Med, Novosibirsk, Russia.

Kubínová, Růžena (författare): Natl Inst Publ Hlth, Prague, Czech Republic.

Tamosiunas, Abdonas (författare): Lithuanian Univ Hlth Sci, Inst Cardiol, Kaunas, Lithuania.

Bobak, Martin (författare): UCL, Dept Epidemiol & Publ Hlth, London, England.

Katsoulis, Michail (författare): Hellen Hlth Fdn, Athens, Greece.

Orfanos, Philippos (författare): Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.

Boffetta, Paolo (författare): Hellen Hlth Fdn, Athens, Greece.;Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.

Trichopoulou, Antonia (författare): Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.

Brenner, Hermann (författare): Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.

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Heidelberg Univ, Network Aging Res, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany. German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany. (creator_code:org_t)

2016-04-05
2016
Engelska.
Ingår i: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 14

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://bmcmedicine....; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality.Methods: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs.Results: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking.Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Smoking
Cancer
Incidence
Mortality
Cohort
Meta-analysis

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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Artiklar i publikationen: BMC Medicine

Av lärosätet: Umeå universitet; Karolinska Institutet; Uppsala universitet

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