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Predicting the effe...
Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank
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- Carter, Paul (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Vithayathil, Mathew (författare)
- Univ Cambridge, MRC Canc Unit, Cambridge, England.
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- Kar, Siddhartha (författare)
- Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
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- Potluri, Rahul (författare)
- Aston Med Sch, ACALM Study Unit, Birmingham, W Midlands, England.
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- Mason, Amy M. (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Burgess, Stephen (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, MRC Biostat Unit, Cambridge, England.
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Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England Univ Cambridge, MRC Canc Unit, Cambridge, England. (creator_code:org_t)
- 2020
- 2020
- Engelska.
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Ingår i: eLIFE. - 2050-084X. ; 9
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained associations of lipid-related genetic variants with the risk of overall and 22 site-specific cancers for 367,703 individuals in the UK Biobank. In total, 75,037 individuals had a cancer event. Variants in the HMGCR gene region, which represent proxies for statin treatment, were associated with overall cancer risk (odds ratio [OR] per one standard deviation decrease in low-density lipoprotein [LDL] cholesterol 0.76, 95% confidence interval [CI] 0.65-0.88, p=0.0003) but variants in gene regions representing alternative lipid-lowering treatment targets (PCSK9, LDLR, NPC1L1, APOC3, LPL) were not. Genetically predicted LDL-cholesterol was not associated with overall cancer risk (OR per standard deviation increase 1.01, 95% CI 0.98-1.05, p=0.50). Our results predict that statins reduce cancer risk but other lipidlowering treatments do not. This suggests that statins reduce cancer risk through a cholesterol independent pathway.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (ämneskategori)
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