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Maternal serum perf...
Maternal serum perfluoroalkyl substance mixtures and thyroid hormone concentrations in maternal and cord sera : The HOME Study
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- Lebeaux, Rebecca M (författare)
- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
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- Doherty, Brett T (författare)
- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
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- Gallagher, Lisa G (författare)
- Independent Researcher, Walpole MA, USA
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- Zoeller, R. Thomas, 1952- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Biology, University of Massachusetts, Amherst MA, USA
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- Hoofnagle, Andrew N (författare)
- Department of Laboratory Medicine, University of Washington, Seattle WA, USA
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- Calafat, Antonia M (författare)
- Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta GA, USA
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- Karagas, Margaret R (författare)
- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
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- Yolton, Kimberly (författare)
- Division of Generaland Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati OH, USA
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- Chen, Aimin (författare)
- Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati OH, USA
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- Lanphear, Bruce P (författare)
- Child and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver British Columbia, Canada
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- Braun, Joseph M (författare)
- Department of Epidemiology, Brown University School of Public Health, Providence RI, USA
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- Romano, Megan E (författare)
- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon NH, USA
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 185
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are ubiquitous. Previous studies have found associations between PFAS and thyroid hormones in maternal and cord sera, but the results are inconsistent. To further address this research question, we used mixture modeling to assess the associations with individual PFAS, interactions among PFAS chemicals, and the overall mixture.METHODS: We collected data through the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort study that between 2003 and 2006 enrolled 468 pregnant women and their children in the greater Cincinnati, Ohio region. We assessed the associations of maternal serum PFAS concentrations measured during pregnancy with maternal (n = 185) and cord (n = 256) sera thyroid stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), and free triiodothyronine (FT3) using two mixture modeling approaches (Bayesian kernel machine regression (BKMR) and quantile g-computation) and multivariable linear regression. Additional models considered thyroid autoantibodies, other non-PFAS chemicals, and iodine deficiency as potential confounders or effect measure modifiers.RESULTS: PFAS, considered individually or as mixtures, were generally not associated with any thyroid hormones. A doubling of perfluorooctanesulfonic acid (PFOS) had a positive association with cord serum TSH in BKMR models but the 95% Credible Interval included the null (β = 0.09; 95% CrI: -0.08, 0.27). Using BKMR and multivariable models, we found that among children born to mothers with higher thyroid peroxidase antibody (TPOAb), perfluorooctanoic acid (PFOA), PFOS, and perfluorohexanesulfonic acid (PFHxS) were associated with decreased cord FT4 suggesting modification by maternal TPOAb status.CONCLUSIONS: These findings suggest that maternal serum PFAS concentrations measured in the second trimester of pregnancy are not strongly associated with thyroid hormones in maternal and cord sera. Further analyses using robust mixture models in other cohorts are required to corroborate these findings.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Epidemiology
- Mixture models
- Perfluoroalkyl substances (PFAS)
- Pregnancy
- Thyroid hormones
- Enviromental Science
- Miljövetenskap
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- art (ämneskategori)
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Lebeaux, Rebecca ...
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Doherty, Brett T
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Gallagher, Lisa ...
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Zoeller, R. Thom ...
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Hoofnagle, Andre ...
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Calafat, Antonia ...
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Karagas, Margare ...
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Yolton, Kimberly
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Chen, Aimin
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Lanphear, Bruce ...
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Braun, Joseph M
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Romano, Megan E
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