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Cerebrovascular int...
Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum
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- Johansson, Jarkko (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Karalija, Nina, 1984- (författare)
- Umeå universitet,Diagnostisk radiologi,Aging Research Center, Karolinska Institutet & Stockholm University, S-17165 Stockholm, Sweden
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- Salami, Alireza (författare)
- Umeå universitet,Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för integrativ medicinsk biologi (IMB),Aging Research Center, Karolinska Institutet & Stockholm University, S-17165 Stockholm, Sweden
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Aging Brain. - : Elsevier. - 2589-9589. ; 4
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Extant research suggest aging-related losses of different dopaminergic markers, including presynaptic dopamine transporters as well as post-synaptic DA receptors. Given the central role of DA in neurocognitive functions, maintenance of a healthy DA system may be a key to mitigate age-related cognitive decline. Mechanisms behind DA losses in aging are however largely uncharted. Past research documented an association between dopaminergic integrity and cerebrovascular health (via white matter lesion volumes). However, it remains unclear whether proximity to lesions affected the spatial patterns of age-related D1DR differences within the striatum, and whether such differences are related to mnemonic function. Here, a large cohort of middle-aged to older healthy participants (age = 40–80 years, n = 119, 50 % women) was assessed for D1-receptor (D1DR) availability with positron emission tomography using [11C]SCH23390, and for white matter lesions using FLAIR-MRI. We found evidence for variations in degree of age-related differences along the ventro-dorsal axis, with more pronounced differences in the dorsal caudate. Further analyses revealed an association between distance to lesions and extent of D1DR losses in the caudate. Furthermore, D1DR differences in dorsal caudate (proximal to lesions) was more strongly associated with memory performance. In conclusion, the present findings suggest that maintenance of cerebrovascular health may be a key factor in promoting successful dopaminergic and memory aging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Dopamine
- Aging
- Cerebrovascular integrity
- Cognition
- White matter lesions
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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