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Use of plasma bioma...
Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias
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Alcolea, D. (author)
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Delaby, C. (author)
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Muñoz, L. (author)
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show more...
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Torres, S. (author)
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Estellés, T. (author)
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Zhu, N. (author)
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Barroeta, I. (author)
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Carmona-Iragui, M. (author)
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Illán-Gala, I. (author)
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Santos-Santos, M. Á (author)
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Altuna, M. (author)
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Sala, I. (author)
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Sánchez-Saudinós, Mª B. (author)
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Videla, L. (author)
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Valldeneu, S. (author)
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Subirana, A. (author)
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Pegueroles, J. (author)
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Hirtz, C. (author)
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Vialaret, J. (author)
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Lehmann, S. (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Belbin, O. (author)
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Blesa, R. (author)
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Clarimón, J. (author)
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Fortea, J. (author)
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Lleó, A. (author)
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(creator_code:org_t)
- 2021-06-08
- 2021
- English.
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In: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 92:11, s. 1206-1214
- Related links:
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https://discovery.uc...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objectives: All categories included in the AT(N) classification can now be measured in plasma. However, their agreement with cerebrospinal fluid (CSF) markers is not fully established. A blood signature to generate the AT(N) classification would facilitate early diagnosis of patients with Alzheimer's disease (AD) through an easy and minimally invasive approach. Methods: We measured Aβ, pTau181 and neurofilament light (NfL) in 150 plasma samples of the Sant Pau Initiative on Neurodegeneration cohort including patients with mild cognitive impairment, AD dementia, frontotemporal dementia, dementia with Lewy bodies and cognitively normal participants. We classified participants in the AT(N) categories according to CSF biomarkers and studied the diagnostic value of plasma biomarkers within each category individually and in combination. Results: The plasma Aβ composite, pTau181 and NfL yielded areas under the curve (AUC) of 0.75, 0.78 and 0.88 to discriminate positive and negative participants in their respective A, T and N categories. The combination of all three markers did not outperform pTau181 alone (AUC=0.81) to discriminate A+T+ from A-T- participants. There was a moderate correlation between plasma Aβ composite and CSF Aβ1-42/Aβ1-40 (Rho=-0.5, p<0.001) and between plasma pTau181 and CSF pTau181 in the entire cohort (Rho=0.51, p<0.001). NfL levels in plasma showed high correlation with those in CSF (Rho=0.78, p<0.001). Conclusions: Plasma biomarkers are useful to detect the AT(N) categories, and their use can differentiate patients with pathophysiological evidence of AD. A blood AT(N) signature may facilitate early diagnosis and follow-up of patients with AD through an easy and minimally invasive approach. © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- amyloid
- csf
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Alcolea, D.
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Delaby, C.
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Muñoz, L.
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Torres, S.
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Estellés, T.
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Zhu, N.
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show more...
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Barroeta, I.
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Carmona-Iragui, ...
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Illán-Gala, I.
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Santos-Santos, M ...
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Altuna, M.
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Sala, I.
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Sánchez-Saudinós ...
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Videla, L.
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Valldeneu, S.
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Subirana, A.
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Pegueroles, J.
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Hirtz, C.
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Vialaret, J.
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Lehmann, S.
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Karikari, Thomas
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Ashton, Nicholas ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Belbin, O.
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Blesa, R.
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Clarimón, J.
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Fortea, J.
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Lleó, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg