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Traffic-related air...
Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
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Castro-Giner, Francesc (författare)
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Künzli, Nino (författare)
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Jacquemin, Bénédicte (författare)
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visa fler...
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- Forsberg, Bertil (författare)
- Umeå universitet,Yrkes- och miljömedicin
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de Cid, Rafael (författare)
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Sunyer, Jordi (författare)
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Jarvis, Deborah (författare)
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Briggs, David (författare)
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Vienneau, Danielle (författare)
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- Norback, Dan (författare)
- Uppsala universitet,Arbets- och miljömedicin,Eva Vingård
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González, Juan R (författare)
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Guerra, Stefano (författare)
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- Janson, Christer (författare)
- Uppsala universitet,Lungmedicin och allergologi
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Antó, Josep-Maria (författare)
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Wjst, Matthias (författare)
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Heinrich, Joachim (författare)
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Estivill, Xavier (författare)
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Kogevinas, Manolis (författare)
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(creator_code:org_t)
- Environmental Health Perspectives, 2009
- 2009
- Engelska.
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Ingår i: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 117:12, s. 1919-1924
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
Nyckelord
- air pollution
- asthma
- gene polymorphisms
- genetics
- nitrogen dioxide
- oxidative stress
- traffic pollution
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Castro-Giner, Fr ...
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Künzli, Nino
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Jacquemin, Bénéd ...
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Forsberg, Bertil
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de Cid, Rafael
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Sunyer, Jordi
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visa fler...
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Jarvis, Deborah
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Briggs, David
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Vienneau, Daniel ...
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Norback, Dan
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González, Juan R
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Guerra, Stefano
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Janson, Christer
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Antó, Josep-Mari ...
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Wjst, Matthias
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Heinrich, Joachi ...
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Estivill, Xavier
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Kogevinas, Manol ...
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visa färre...
- Artiklar i publikationen
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Journal of Envir ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet