Sökning: onr:"swepub:oai:lup.lub.lu.se:9d79af9b-ce10-41fa-8ae3-c8efd0d4e17b" >
Coronary Hemodynami...
Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement : Implications for Clinical Indices of Coronary Stenosis Severity
-
- Ahmad, Yousif (författare)
- Hammersmith Hospital,Imperial College London
-
- Götberg, Matthias (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Cook, Christopher (författare)
- Imperial College London,Hammersmith Hospital
-
visa fler...
-
- Howard, James P. (författare)
- Imperial College London,Hammersmith Hospital
-
- Malik, Iqbal (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Mikhail, Ghada (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Frame, Angela (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Petraco, Ricardo (författare)
- Imperial College London,Hammersmith Hospital
-
- Rajkumar, Christopher (författare)
- Imperial College London,Hammersmith Hospital
-
- Demir, Ozan (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Iglesias, Juan F. (författare)
- Lausanne University Hospital
-
- Bhindi, Ravinay (författare)
- Royal North Shore Hospital
-
- Koul, Sasha (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
-
- Hadjiloizou, Nearchos (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Gerber, Robert (författare)
- Conquest Hospital
-
- Ramrakha, Punit (författare)
- Imperial College Healthcare NHS Trust,Hammersmith Hospital
-
- Ruparelia, Neil (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Sutaria, Nilesh (författare)
- Imperial College Healthcare NHS Trust,Hammersmith Hospital
-
- Kanaganayagam, Gajen (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Ariff, Ben (författare)
- Imperial College Healthcare NHS Trust,Hammersmith Hospital
-
- Fertleman, Michael (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Anderson, Jon (författare)
- Imperial College Healthcare NHS Trust,Hammersmith Hospital
-
- Chukwuemeka, Andrew (författare)
- Hammersmith Hospital,Imperial College Healthcare NHS Trust
-
- Francis, Darrel (författare)
- Imperial College London,Hammersmith Hospital
-
- Mayet, Jamil (författare)
- Hammersmith Hospital,Imperial College London
-
- Serruys, Patrick (författare)
- Imperial College London,Hammersmith Hospital
-
- Davies, Justin (författare)
- Hammersmith Hospital,Imperial College London
-
- Sen, Sayan (författare)
- Hammersmith Hospital,Imperial College London
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska 13 s.
-
Ingår i: JACC: Cardiovascular Interventions. - : Elsevier BV. - 1876-7605 .- 1936-8798. ; 11:20, s. 2019-2031
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES: In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) and coronary artery disease, undergoing transcatheter aortic valve replacement (TAVR), to determine how AS affects: 1) phasic coronary flow; 2) hyperemic coronary flow; and 3) the most common clinically used indices of coronary stenosis severity, instantaneous wave-free ratio and fractional flow reserve.BACKGROUND: A significant proportion of patients with severe aortic stenosis (AS) have concomitant coronary artery disease. The effect of the valve on coronary pressure, flow, and the established invasive clinical indices of stenosis severity have not been studied.METHODS: Twenty-eight patients (30 lesions, 50.0% men, mean age 82.1 ± 6.5 years) with severe AS and coronary artery disease were included. Intracoronary pressure and flow assessments were performed at rest and during hyperemia immediately before and after TAVR.RESULTS: Flow during the wave-free period of diastole did not change post-TAVR (29.78 ± 14.9 cm/s vs. 30.81 ± 19.6 cm/s; p = 0.64). Whole-cycle hyperemic flow increased significantly post-TAVR (33.44 ± 13.4 cm/s pre-TAVR vs. 40.33 ± 17.4 cm/s post-TAVR; p = 0.006); this was secondary to significant increases in systolic hyperemic flow post-TAVR (27.67 ± 12.1 cm/s pre-TAVR vs. 34.15 ± 17.5 cm/s post-TAVR; p = 0.02). Instantaneous wave-free ratio values did not change post-TAVR (0.88 ± 0.09 pre-TAVR vs. 0.88 ± 0.09 post-TAVR; p = 0.73), whereas fractional flow reserve decreased significantly post-TAVR (0.87 ± 0.08 pre-TAVR vs. 0.85 ± 0.09 post-TAVR; p = 0.001).CONCLUSIONS: Systolic and hyperemic coronary flow increased significantly post-TAVR; consequently, hyperemic indices that include systole underestimated coronary stenosis severity in patients with severe AS. Flow during the wave-free period of diastole did not change post-TAVR, suggesting that indices calculated during this period are not vulnerable to the confounding effect of the stenotic aortic valve.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- aortic stenosis
- coronary flow
- fractional flow reserve
- instantaneous wave-free ratio
- TAVR
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ahmad, Yousif
-
Götberg, Matthia ...
-
Cook, Christophe ...
-
Howard, James P.
-
Malik, Iqbal
-
Mikhail, Ghada
-
visa fler...
-
Frame, Angela
-
Petraco, Ricardo
-
Rajkumar, Christ ...
-
Demir, Ozan
-
Iglesias, Juan F ...
-
Bhindi, Ravinay
-
Koul, Sasha
-
Hadjiloizou, Nea ...
-
Gerber, Robert
-
Ramrakha, Punit
-
Ruparelia, Neil
-
Sutaria, Nilesh
-
Kanaganayagam, G ...
-
Ariff, Ben
-
Fertleman, Micha ...
-
Anderson, Jon
-
Chukwuemeka, And ...
-
Francis, Darrel
-
Mayet, Jamil
-
Serruys, Patrick
-
Davies, Justin
-
Sen, Sayan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
JACC: Cardiovasc ...
- Av lärosätet
-
Lunds universitet