Sökning: WFRF:(Krischer Jeffrey P) >
Dietary Intake and ...
Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children : A Mediation Analysis Using the TEDDY Cohort
-
- Aronsson, Carin Andrén (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
-
- Tamura, Roy (författare)
- University of South Florida
-
- Vehik, Kendra (författare)
- University of South Florida
-
visa fler...
-
- Uusitalo, Ulla (författare)
- University of South Florida
-
- Yang, Jimin (författare)
- University of South Florida
-
- Haller, Michael J. (författare)
- University of Florida
-
- Toppari, Jorma (författare)
- Turku University Hospital,University of Turku
-
- Hagopian, William (författare)
- Pacific Northwest Research Institute
-
- McIndoe, Richard A. (författare)
- Medical College of Georgia
-
- Rewers, Marian J. (författare)
- Barbara Davis Center for Childhood Diabetes
-
- Ziegler, Anette G. (författare)
- Klinikum rechts der Isar
-
- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
-
- Krischer, Jeffrey P. (författare)
- University of South Florida
-
- Norris, Jill M. (författare)
- University of Colorado
-
- Virtanen, Suvi M. (författare)
- University of Tampere,Tampere University Hospital,Finnish National Institute for Health and Welfare
-
- Larsson, Helena Elding (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital
-
visa färre...
-
(creator_code:org_t)
- Hindawi Limited, 2023
- 2023
- Engelska.
-
Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 2023
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background/Objective: Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. Research Design and Methods: Genetically at-risk children (n = 5,084) in Finland, Germany, Sweden, and the USA, who were autoantibody negative at 2 years of age, were followed to the age of 8 years, with anthropometric measurements and 3-day food records collected biannually. Of these, 495 (9.7%) children developed IA. Mediation analysis for time-varying covariates (BMI z-score) and exposure (energy intake) was conducted. Cox proportional hazard method was used in sensitivity analysis. Results: We found an indirect effect of total energy intake (estimates: indirect effect 0.13 [0.05, 0.21]) and energy from protein (estimates: indirect effect 0.06 [0.02, 0.11]), fat (estimates: indirect effect 0.03 [0.01, 0.05]), and carbohydrates (estimates: indirect effect 0.02 [0.00, 0.04]) (kcal/day) on the development of IA. A direct effect was found for protein, expressed both as kcal/day (estimates: direct effect 1.09 [0.35, 1.56]) and energy percentage (estimates: direct effect 72.8 [3.0, 98.0]) and the development of GAD autoantibodies (GADA). In the sensitivity analysis, energy from protein (kcal/day) was associated with increased risk for GADA, hazard ratio 1.24 (95% CI: 1.09, 1.53), p = 0.042. Conclusions: This study confirms that higher total energy intake is associated with higher BMI, which leads to higher risk of the development of IA. A diet with larger proportion of energy from protein has a direct effect on the development of GADA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Aronsson, Carin ...
-
Tamura, Roy
-
Vehik, Kendra
-
Uusitalo, Ulla
-
Yang, Jimin
-
Haller, Michael ...
-
visa fler...
-
Toppari, Jorma
-
Hagopian, Willia ...
-
McIndoe, Richard ...
-
Rewers, Marian J ...
-
Ziegler, Anette ...
-
Akolkar, Beena
-
Krischer, Jeffre ...
-
Norris, Jill M.
-
Virtanen, Suvi M ...
-
Larsson, Helena ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Pediatric Diabet ...
- Av lärosätet
-
Lunds universitet