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Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study
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- Dixon-Suen, Suzanne C (author)
- Cancer Council Victoria
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Lewis, Sarah J (author)
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Martin, Richard M (author)
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show more...
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English, Dallas R (author)
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Boyle, Terry (author)
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Giles, Graham G (author)
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Michailidou, Kyriaki (author)
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Bolla, Manjeet K (author)
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Wang, Qin (author)
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Dennis, Joe (author)
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Lush, Michael (author)
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Investigators, Abctb (author)
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Ahearn, Thomas U (author)
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Ambrosone, Christine B (author)
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- Andrulis, Irene L (author)
- Karolinska Institutet
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Anton-Culver, Hoda (author)
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Arndt, Volker (author)
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Aronson, Kristan J (author)
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- Augustinsson, A. (author)
- Lund University,Lunds universitet,Karolinska Institutet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Biomarkers and epidemiology,Department of Clinical Sciences, Lund
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Auvinen, Päivi (author)
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Beane Freeman, Laura E (author)
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Becher, Heiko (author)
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Beckmann, Matthias W (author)
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Behrens, Sabine (author)
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- Bermisheva, Marina (author)
- University of Melbourne,Cancer Council Victoria
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Blomqvist, Carl (author)
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Bogdanova, Natalia V (author)
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Bojesen, Stig E (author)
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Bonanni, Bernardo (author)
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Brenner, Hermann (author)
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Brüning, Thomas (author)
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Buys, Saundra S (author)
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Camp, Nicola J (author)
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Campa, Daniele (author)
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Canzian, Federico (author)
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Castelao, Jose E (author)
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Cessna, Melissa H (author)
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Chang-Claude, Jenny (author)
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Chanock, Stephen J (author)
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Clarke, Christine L (author)
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Conroy, Don M (author)
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Couch, Fergus J (author)
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Cox, Angela (author)
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Cross, Simon S (author)
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- Czene, Kamila (author)
- Karolinska Institutet
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Daly, Mary B (author)
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Devilee, Peter (author)
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Dörk, Thilo (author)
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Dwek, Miriam (author)
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Eccles, Diana M (author)
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Eliassen, A Heather (author)
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Engel, Christoph (author)
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- Eriksson, Mikael (author)
- Karolinska Institutet
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Evans, D Gareth (author)
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Fasching, Peter A (author)
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Fletcher, Olivia (author)
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Flyger, Henrik (author)
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Fritschi, Lin (author)
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- Gabrielson, Marike (author)
- Karolinska Institutet
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Gago-Dominguez, Manuela (author)
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García-Closas, Montserrat (author)
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García-Sáenz, José A (author)
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Goldberg, Mark S (author)
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Guénel, Pascal (author)
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Gündert, Melanie (author)
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Hahnen, Eric (author)
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Haiman, Christopher A (author)
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Häberle, Lothar (author)
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- Håkansson, Niclas (author)
- Karolinska Institutet
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- Hall, Per (author)
- Karolinska Institutet
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Hamann, Ute (author)
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Hart, Steven N (author)
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Harvie, Michelle (author)
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Hillemanns, Peter (author)
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Hollestelle, Antoinette (author)
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Hooning, Maartje J (author)
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Hoppe, Reiner (author)
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Hopper, John (author)
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Howell, Anthony (author)
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Hunter, David J (author)
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Jakubowska, Anna (author)
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Janni, Wolfgang (author)
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John, Esther M (author)
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Jung, Audrey (author)
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Kaaks, Rudolf (author)
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Keeman, Renske (author)
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Kitahara, Cari M (author)
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Koutros, Stella (author)
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Kraft, Peter (author)
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Kristensen, Vessela N (author)
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Kubelka-Sabit, Katerina (author)
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Kurian, Allison W (author)
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Lacey, James V (author)
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Lambrechts, Diether (author)
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Le Marchand, Loic (author)
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Lindblom, Annika (author)
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Loibl, Sibylle (author)
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Lubiński, Jan (author)
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Mannermaa, Arto (author)
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Manoochehri, Mehdi (author)
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- Margolin, Sara (author)
- Karolinska Institutet
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Martinez, Maria Elena (author)
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Mavroudis, Dimitrios (author)
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Menon, Usha (author)
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Mulligan, Anna Marie (author)
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Murphy, Rachel A (author)
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Collaborators, Nbcs (author)
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Nevanlinna, Heli (author)
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Nevelsteen, Ines (author)
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Newman, William G (author)
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Offit, Kenneth (author)
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Olshan, Andrew F (author)
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- Olsson, H. (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Orr, Nick (author)
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Patel, Alpa (author)
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Peto, Julian (author)
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Plaseska-Karanfilska, Dijana (author)
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Presneau, Nadege (author)
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Rack, Brigitte (author)
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Radice, Paolo (author)
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Rees-Punia, Erika (author)
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Rennert, Gad (author)
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Rennert, Hedy S (author)
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Romero, Atocha (author)
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Saloustros, Emmanouil (author)
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Sandler, Dale P (author)
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Schmidt, Marjanka K (author)
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Schmutzler, Rita K (author)
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Schwentner, Lukas (author)
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Scott, Christopher (author)
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Shah, Mitul (author)
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Shu, Xiao-Ou (author)
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Simard, Jacques (author)
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Southey, Melissa C (author)
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Stone, Jennifer (author)
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Surowy, Harald (author)
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Swerdlow, Anthony J (author)
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Tamimi, Rulla M (author)
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Tapper, William J (author)
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Taylor, Jack A (author)
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Terry, Mary Beth (author)
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Tollenaar, Rob A E M (author)
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Troester, Melissa A (author)
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Truong, Thérèse (author)
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Untch, Michael (author)
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Vachon, Celine M (author)
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Joseph, Vijai (author)
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Wappenschmidt, Barbara (author)
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Weinberg, Clarice R (author)
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- Wolk, Alicja (author)
- Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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Yannoukakos, Drakoulis (author)
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Zheng, Wei (author)
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Ziogas, Argyrios (author)
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Dunning, Alison M (author)
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Pharoah, Paul D P (author)
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Easton, Douglas F (author)
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Milne, Roger L (author)
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Lynch, Brigid M (author)
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(creator_code:org_t)
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- 2022-09-06
- 2022
- English.
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In: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 56:20, s. 1157-1170
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Breast
- Genetics
- Physical activity
- Sedentary Behaviour
Publication and Content Type
- ref (subject category)
- art (subject category)
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Dixon-Suen, Suza ...
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Lewis, Sarah J
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Martin, Richard ...
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English, Dallas ...
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Boyle, Terry
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Giles, Graham G
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Michailidou, Kyr ...
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Bolla, Manjeet K
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Wang, Qin
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Dennis, Joe
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Lush, Michael
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Investigators, A ...
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Ahearn, Thomas U
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Ambrosone, Chris ...
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Andrulis, Irene ...
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Anton-Culver, Ho ...
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Arndt, Volker
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Aronson, Kristan ...
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Augustinsson, A.
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Auvinen, Päivi
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Beane Freeman, L ...
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Becher, Heiko
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Beckmann, Matthi ...
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Behrens, Sabine
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Bermisheva, Mari ...
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Blomqvist, Carl
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Bogdanova, Natal ...
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Bojesen, Stig E
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Bonanni, Bernard ...
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Brenner, Hermann
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Brüning, Thomas
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Buys, Saundra S
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Camp, Nicola J
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Campa, Daniele
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Canzian, Federic ...
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Castelao, Jose E
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Cessna, Melissa ...
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Chang-Claude, Je ...
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Chanock, Stephen ...
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Clarke, Christin ...
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Conroy, Don M
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Couch, Fergus J
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Cox, Angela
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Cross, Simon S
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Czene, Kamila
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Daly, Mary B
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Devilee, Peter
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Dörk, Thilo
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Dwek, Miriam
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Eccles, Diana M
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Eliassen, A Heat ...
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Engel, Christoph
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Eriksson, Mikael
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Evans, D Gareth
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Fasching, Peter ...
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Fletcher, Olivia
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Flyger, Henrik
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Fritschi, Lin
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Gabrielson, Mari ...
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Gago-Dominguez, ...
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García-Closas, M ...
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García-Sáenz, Jo ...
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Goldberg, Mark S
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Guénel, Pascal
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Gündert, Melanie
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Hahnen, Eric
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Haiman, Christop ...
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Häberle, Lothar
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Håkansson, Nicla ...
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Hall, Per
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Hamann, Ute
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Hart, Steven N
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Harvie, Michelle
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Hillemanns, Pete ...
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Hollestelle, Ant ...
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Hooning, Maartje ...
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Hoppe, Reiner
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Hopper, John
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Howell, Anthony
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Hunter, David J
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Jakubowska, Anna
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Janni, Wolfgang
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John, Esther M
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Jung, Audrey
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Kaaks, Rudolf
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Keeman, Renske
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Kitahara, Cari M
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Koutros, Stella
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Kraft, Peter
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Kristensen, Vess ...
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Kubelka-Sabit, K ...
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Kurian, Allison ...
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Lacey, James V
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Lambrechts, Diet ...
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Le Marchand, Loi ...
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Lindblom, Annika
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Loibl, Sibylle
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Lubiński, Jan
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Mannermaa, Arto
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Manoochehri, Meh ...
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Margolin, Sara
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Martinez, Maria ...
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Mavroudis, Dimit ...
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Menon, Usha
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Mulligan, Anna M ...
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Murphy, Rachel A
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Collaborators, N ...
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Nevanlinna, Heli
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Nevelsteen, Ines
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Newman, William ...
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Offit, Kenneth
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Olshan, Andrew F
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Olsson, H.
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Orr, Nick
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Patel, Alpa
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Peto, Julian
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Plaseska-Karanfi ...
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Presneau, Nadege
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Rack, Brigitte
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Radice, Paolo
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Rees-Punia, Erik ...
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Rennert, Gad
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Rennert, Hedy S
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Romero, Atocha
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Saloustros, Emma ...
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Sandler, Dale P
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Schmidt, Marjank ...
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Schmutzler, Rita ...
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Schwentner, Luka ...
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Scott, Christoph ...
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Shah, Mitul
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Shu, Xiao-Ou
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Simard, Jacques
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Southey, Melissa ...
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Stone, Jennifer
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Surowy, Harald
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Swerdlow, Anthon ...
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Tamimi, Rulla M
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Tapper, William ...
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Taylor, Jack A
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Terry, Mary Beth
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Tollenaar, Rob A ...
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Troester, Meliss ...
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Truong, Thérèse
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Untch, Michael
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Vachon, Celine M
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Joseph, Vijai
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Wappenschmidt, B ...
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Weinberg, Claric ...
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Wolk, Alicja
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Yannoukakos, Dra ...
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Zheng, Wei
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Ziogas, Argyrios
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Dunning, Alison ...
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Pharoah, Paul D ...
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Easton, Douglas ...
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Milne, Roger L
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Lynch, Brigid M
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Uppsala University
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Karolinska Institutet
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