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Determinants of per...
Determinants of persistent asthma in young adults
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- Traulsen, Lisbet Krogh (author)
- University of Southern Denmark
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- Halling, Anders (author)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups
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- Bælum, Jesper (author)
- University of Southern Denmark
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- Davidsen, Jesper Rømhild (author)
- Odense University Hospital
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- Miller, Martin (author)
- University of Birmingham
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- Omland, Øyvind (author)
- Aalborg University Hospital
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- Sherson, David (author)
- Odense University Hospital
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- Sigsgaard, Torben (author)
- Aarhus University Hospital
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Thilsing, Trine (author)
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- Thomsen, Gert (author)
- Hospital of South West Jutland, Esbjerg
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Skadhauge, Lars Rauff (author)
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(creator_code:org_t)
- 2018-06-05
- 2018
- English.
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In: European clinical respiratory journal. - : Informa UK Limited. - 2001-8525. ; 5:1, s. 1-9
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Abstract
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- Objective: The aim of the study was to evaluate determinants for the prognosis of asthma in a population-based cohort of young adults. Design: The study was a nine-year clinical follow up of 239 asthmatic subjects from an enriched population-based sample of 1,191 young adults, aged 20-44 years, who participated in an interviewer-administered questionnaire and clinical examination at baseline in 2003-2006. From the interview, an asthma score was generated as the simple sum of affirmative answers to five main asthma-like symptoms in order to analyse symptoms of asthma as a continuum. The clinical examination comprised spirometry, bronchial challenge or bronchodilation, and skin prick test. Results: Among the 239 individuals with asthma at baseline 164 (69%) had persistent asthma at follow up, while 68 (28%) achieved remission of asthma and seven (3%) were diagnosed with COPD solely. Determinants for persistent asthma were use of medication for breathing within the last 12 months: Short-acting beta-adrenoceptor agonists (SABA) only (OR 3.39; 95%CI: 1.47-7.82) and inhaled corticosteroids (ICS) and/or long-acting beta-adrenoceptor agonists (LABA) (8.95; 3.87-20.69). Stratified by age of onset determinants for persistence in individuals with early-onset asthma (age less than 16 years) were FEV₁ below predicted (7.12; 1.61-31.50), asthma score at baseline (2.06; 1.15-3.68) and use of ICS and/or LABA within 12 months (9.87; 1.95-49.98). In individuals with late-onset asthma the determinant was use of ICS and/or LABA within 12 months (6.84; 2.09-22.37). Conclusions: Pulmonary function below predicted, severity of disease expressed by asthma score and use of ICS and/or LABA were all determinants for persistent early-onset asthma, whereas only use of ICS and/or LABA was a determinant in late-onset asthma. A high asthma score indicated insufficient disease control in a substantial proportion of these young adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Traulsen, Lisbet ...
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Halling, Anders
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Bælum, Jesper
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Davidsen, Jesper ...
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Miller, Martin
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Omland, Øyvind
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Sherson, David
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Sigsgaard, Torbe ...
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Thilsing, Trine
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Thomsen, Gert
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Skadhauge, Lars ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European clinica ...
- By the university
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Lund University