Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

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Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models : results from the EPIC cohort

Fortner, Renee T. (författare): German Cancer Research Centre

Vitonis, Allison F. (författare): Brigham and Women's Hospital / Harvard Medical School

Schock, Helena (författare): German Cancer Research Centre

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Huesing, Anika (författare): German Cancer Research Centre

Johnson, Theron (författare): German Cancer Research Centre

Fichorova, Raina N. (författare): Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School

Fashemi, Titilayo (författare): Brigham and Women's Hospital / Harvard Medical School

Yamamoto, Hidemi S. (författare): Brigham and Women's Hospital / Harvard Medical School,Istituto Nazionale dei Tumori

Tjonneland, Anne (författare): Danish Cancer Society

Hansen, Louise (författare): Danish Cancer Society

Overvad, Kim (författare): Aarhus University

Boutron-Ruault, Marie-Christine (författare): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay

Kvaskoff, Marina (författare): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay

Severi, Gianluca (författare): University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF)

Boeing, Heiner (författare): German Institute of Human Nutrition

Trichopoulou, Antonia (författare): Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens

Benetou, Vassiliki (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

La Vecchia, Carlo (författare): Hellenic Health Foundation, Athens,University of Milan

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Sieri, Sabina (författare)

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Matullo, Giuseppe (författare): Citta' della Salute e della Scienza Hospital-University of Turin

Mattiello, Amalia (författare): University of Naples Federico II

Onland-Moret, N. Charlotte (författare): University Medical Center Utrecht,Utrecht University

Peeters, Petra H. (författare): Imperial College London,University Medical Center Utrecht

Weiderpass, Elisabete (författare): Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research

Gram, Inger Torhild (författare): UiT The Arctic University of Norway, Tromsø

Jareid, Mie (författare): UiT The Arctic University of Norway, Tromsø

Ramon Quiros, J. (författare): Public Health Directorate

Duell, Eric J. (författare): Catalan Institute of Oncology

Sanchez, Maria-Jose (författare): Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)

Dolores Chirlaque, Maria (författare): Murcia Regional Health Authority,University of Murcia

Ardanaz, Eva (författare): Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)

Larranaga, Nerea (författare): CIBER Epidemiology and Public Health (CIBERESP)

Nodin, Björn (författare): Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Brändstedt, Jenny (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital

Idahl, Annika (författare): Umeå University,Umeå universitet,Obstetrik och gynekologi

Khaw, Kay-Tee (författare): University of Cambridge

Allen, Naomi (författare): University of Oxford

Gunter, Marc (författare): International Agency for Research on Cancer, World Health Organization

Johansson, Mattias (författare): International Agency for Research on Cancer, World Health Organization

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization

Merritt, Melissa A. (författare): Imperial College London

Riboli, Elio (författare): Imperial College London

Cramer, Daniel W. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

Kaaks, Rudolf (författare): German Cancer Research Centre

Terry, Kathryn L. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

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(creator_code:org_t)

2017-03-20
2017
Engelska.
Ingår i: Journal of Ovarian Research. - : Springer Science and Business Media LLC. - 1757-2215. ; 10

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://ovarianresea...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression.Results: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination.Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Ovarian cancer
Early detection markers
CA125
CA15.3
HE4
CA125
CA15.3
Early detection markers
HE4
Ovarian cancer

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Av författaren/redakt...: Fortner, Renee T ...; Vitonis, Allison ...; Schock, Helena; Huesing, Anika; Johnson, Theron; Fichorova, Raina ...; visa fler...; Fashemi, Titilay ...; Yamamoto, Hidemi ...; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, ...; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, An ...; Benetou, Vassili ...; La Vecchia, Carl ...; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giusepp ...; Mattiello, Amali ...; Onland-Moret, N. ...; Peeters, Petra H ...; Weiderpass, Elis ...; Gram, Inger Torh ...; Jareid, Mie; Ramon Quiros, J.; Duell, Eric J.; Sanchez, Maria-J ...; Dolores Chirlaqu ...; Ardanaz, Eva; Larranaga, Nerea; Nodin, Björn; Brändstedt, Jenn ...; Idahl, Annika; Khaw, Kay-Tee; Allen, Naomi; Gunter, Marc; Johansson, Matti ...; Dossus, Laure; Merritt, Melissa ...; Riboli, Elio; Cramer, Daniel W ...; Kaaks, Rudolf; Terry, Kathryn L ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

Artiklar i publikationen: Journal of Ovari ...

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