Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study

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Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study

Burisch, Johan (författare): Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark

Katsanos, Konstantinos H. (författare): Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece

Christodoulou, Dimitrios K. (författare): Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece

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Barros, Luisa (författare): Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal

Magro, Fernando (författare): Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal

Pedersen, Natalia (författare): Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark

Kjeldsen, Jens (författare): Gastroenterology Department, Odense University Hospital, Odense, Denmark

Vegh, Zsuzsanna (författare): First Department of Medicine, Semmelweis University, Budapest, Hungary

Lakatos, Peter L. (författare): First Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada

Eriksson, Carl, 1981- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology

Halfvarson, Jonas, 1970- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology

Fumery, Mathurin (författare): Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Amiens, France

Gower-Rousseau, Corinne (författare): Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France; Lille Inflammation Research International Center LIRIC, Lille University, Lille, France

Brinar, Marko (författare): Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Čuković-Čavka, Silvija (författare): Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Nikulina, Inna (författare): Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

Belousova, Elena (författare): Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

Myers, Sally (författare): IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK

Sebastian, Shaji (författare): IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK

Kiudelis, Gediminas (författare): Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Kupcinskas, Limas (författare): Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Schwartz, Doron (författare): Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel

Odes, Selwyn (författare): Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel

Kaimakliotis, Ioannis P. (författare): Nicosia Private Practice, Nicosia, Cyprus

Valpiani, Daniela (författare): U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy

D'Incà, Renata (författare): Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy

Salupere, Riina (författare): Division of Gastroenterology, Tartu University Hospital, University of Tartu, Tartu, Estonia

Zammit, Stefania Chetcuti (författare): Division of Gastroenterology, Mater Dei Hospital, Msida, Malta

Ellul, Pierre (författare): Division of Gastroenterology, Mater Dei Hospital, Msida, Malta

Duricova, Dana (författare): IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic

Bortlik, Martin (författare): IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic; Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

Goldis, Adrian (författare): Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania

Kievit, Hendrika Adriana Linda (författare): Department of Medicine, Herning Central Hospital, Herning, Denmark

Toca, Alina (författare): Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova

Turcan, Svetlana (författare): Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova

Midjord, Jóngerð (författare): Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands

Nielsen, Kári Rubek (författare): Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands

Andersen, Karina Winther (författare): Medical Department, Regional Hospital of Viborg, Viborg, Denmark

Andersen, Vibeke (författare): Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused Research Unit for Molecular Diagnostic and Clinical Research [MOK], IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark

Misra, Ravi (författare): IBD Department, St Mark’s Hospital, London, UK

Arebi, Naila (författare): IBD Department, St Mark’s Hospital, London, UK

Oksanen, Pia (författare): Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland

Collin, Pekka (författare): Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland

de Castro, Luisa (författare): Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain

Hernandez, Vicent (författare): Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain

Langholz, Ebbe (författare): Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

Munkholm, Pia (författare): Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark

Epi-IBD, Group (bidragsgivare)

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(creator_code:org_t)

2018-10-05
2019
Engelska.
Ingår i: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 13:2, s. 198-208

Relaterad länk:: http://repo.lib.semm...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

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Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort.Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8].Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.

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Journal of Crohn's & Colitis (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Burisch, Johan; Katsanos, Konsta ...; Christodoulou, D ...; Barros, Luisa; Magro, Fernando; Pedersen, Natali ...; visa fler...; Kjeldsen, Jens; Vegh, Zsuzsanna; Lakatos, Peter L ...; Eriksson, Carl, ...; Halfvarson, Jona ...; Fumery, Mathurin; Gower-Rousseau, ...; Brinar, Marko; Čuković-Čavka, S ...; Nikulina, Inna; Belousova, Elena; Myers, Sally; Sebastian, Shaji; Kiudelis, Gedimi ...; Kupcinskas, Lima ...; Schwartz, Doron; Odes, Selwyn; Kaimakliotis, Io ...; Valpiani, Daniel ...; D'Incà, Renata; Salupere, Riina; Zammit, Stefania ...; Ellul, Pierre; Duricova, Dana; Bortlik, Martin; Goldis, Adrian; Kievit, Hendrika ...; Toca, Alina; Turcan, Svetlana; Midjord, Jóngerð; Nielsen, Kári Ru ...; Andersen, Karina ...; Andersen, Vibeke; Misra, Ravi; Arebi, Naila; Oksanen, Pia; Collin, Pekka; de Castro, Luisa; Hernandez, Vicen ...; Langholz, Ebbe; Munkholm, Pia; Epi-IBD, Group; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: Journal of Crohn ...

Av lärosätet: Örebro universitet

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Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study

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