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Widespread non-join...
Widespread non-joint pain in early rheumatoid arthritis
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- Schelin, M. E.C. (author)
- Lund University,Lunds universitet,Tillämpad epidemiologi,Forskargrupper vid Lunds universitet,Palliativ vård,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Applied epidemiology,Lund University Research Groups,Palliative care,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Westerlind, H. (author)
- Karolinska Institutet,Karolinska Institute
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- Lindqvist, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Englid, E. (author)
- Karolinska Institutet,Karolinska Institute
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- Israelsson, L. (author)
- Karolinska Institutet,Karolinska Institute
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- Skillgate, E. (author)
- Karolinska Institute
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- Klareskog, L. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Alfredsson, L. (author)
- Karolinska Institutet,Karolinska Institute
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- Lampa, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2021-02-25
- 2021
- English 9 s.
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 50:4, s. 271-279
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Abstract
Subject headings
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- Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA), the associated health-related quality of life (HRQoL), and clinical and demographic risk factors for WNP. Method: Incident cases with RA, from the Swedish population-based study Epidemiological Investigation of Rheumatoid Arthritis (EIRA), with a follow-up of at least 3 years, constituted the study population. WNP was defined as pain outside the joints in all four body quadrants and was assessed at the 3 year follow-up. Patients who reported WNP were compared to patients without WNP regarding HRQoL, measured by the Short Form-36, at 3 years, and clinical and demographic characteristics at the time of RA diagnosis. Results: A total of 749 patients constituted the study sample, of whom 25 were excluded after reporting already having severe pain before RA diagnosis. At the 3 year follow-up, 8% of the patients reported having WNP as well as statistically significant worse HRQoL. At the time of RA diagnosis, the patients with WNP had worse pain and pain-related features, while no difference was seen in the inflammatory parameters. Conclusion: WNP occurs in a substantial subset of patients with RA, also early in the course of the disease, and the HRQoL for these patients is significantly reduced. Patients who develop WNP at 3 years are already distinguishable at the time of diagnosis by displaying more pronounced pain ratings together with an average level of inflammatory disease activity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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