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Obesity is a risk f...
Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: a NORD-STAR study
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- Dubovyk, Violetta (author)
- Univ Gothenburg, Sweden
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- Vasileiadis, Georgios K. (author)
- Univ Gothenburg, Sweden
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- Fatima, Tahzeeb (author)
- Univ Gothenburg, Sweden
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- Zhang, Yuan (author)
- Univ Gothenburg, Sweden
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- Kapetanovic, Meliha Crnkic (author)
- Skane Univ Hosp Lund, Sweden
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Rizk, Milad (author)
- Vastmanlands Hosp, Sweden
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- Soederbergh, Annika (author)
- Orebro Univ Hosp, Sweden
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- Zhao, Sizheng Steven (author)
- Univ Manchester, England
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- van Vollenhoven, Ronald F. (author)
- Amsterdam Rheumatol & Immunol Ctr, Netherlands; Karolinska Inst, Sweden
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- Hetland, Merete Lund (author)
- Rigshosp Glostrup, Denmark; Univ Copenhagen, Denmark
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- Haavardsholm, Espen A. (author)
- Diakonhjemmet Hosp, Norway; Univ Oslo, Norway
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- Nordstrom, Dan (author)
- Univ Helsinki, Finland
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- Nurmohamed, Michael T. (author)
- Amsterdam Rheumatol & Immunol Ctr, Netherlands; Amsterdam Rheumatol & Immunol Ctr, Netherlands
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- Gudbjornsson, Bjorn (author)
- Univ Iceland, Iceland; Landspitali Univ Hosp, Iceland
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- Lampa, Jon (author)
- Karolinska Institutet
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- Ostergaard, Mikkel (author)
- Rigshosp Glostrup, Denmark; Univ Copenhagen, Denmark
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- Heiberg, Marte Schrumpf (author)
- Diakonhjemmet Hosp, Norway
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- Sokka-Isler, Tuulikki (author)
- Univ Eastern Finland, Finland
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- Grondal, Gerdur (author)
- Univ Iceland, Iceland; Landspitali Univ Hosp, Iceland
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- Lend, Kristina (author)
- Karolinska Institutet
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- Horslev-Petersen, Kim (author)
- Univ Hosp Southern Denmark, Denmark; Univ Southern Denmark, Denmark
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- Uhlig, Till (author)
- Diakonhjemmet Hosp, Norway; Univ Oslo, Norway
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- Rudin, Anna (author)
- Univ Gothenburg, Sweden
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- Maglio, Cristina (author)
- Univ Gothenburg, Sweden
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(creator_code:org_t)
- BMJ PUBLISHING GROUP, 2024
- 2024
- English.
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In: RMD Open. - : BMJ PUBLISHING GROUP. - 2056-5933. ; 10:2
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Objective This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response to conventional and biological antirheumatic treatment in early rheumatoid arthritis (RA). Methods This report included 793 participants with untreated early RA from the randomised, longitudinal NORD-STAR trial, all of whom had their body mass index (BMI) assessed at baseline. Obesity was defined as BMI >= 30 kg/m(2). All participants were randomised 1:1:1:1 to one of four treatment arms: active conventional treatment, certolizumab-pegol, abatacept and tocilizumab. Clinical and laboratory measurements were performed at baseline and at 8, 12, 24 and 48-week follow-up. The primary endpoint for this report was response to treatment based on Clinical Disease Activity Index (CDAI) and Simple Disease Activity Index (SDAI) remission and Disease Activity Score with 28 joints using C-reactive protein (DAS28-CRP) <2.6 stratified by BMI. Results Out of 793 people included in the present report, 161 (20%) had obesity at baseline. During follow-up, participants with baseline obesity had higher disease activity compared with those with lower BMI, despite having similar disease activity at baseline. In survival analyses, obesity was associated with a lower likelihood of achieving response to treatment during follow-up for up to 48 weeks (CDAI remission, HR 0.84, 95% CI 0.67 to 1.05; SDAI, HR 0.77, 95% CI 0.62 to 0.97; DAS28-CRP <2.6, HR 0.78, 95% CI 0.64 to 0.95). The effect of obesity on response to treatment was not influenced by the treatment arms. Conclusion In people with untreated early RA followed up for up to 48 weeks, obesity was associated with a lower likelihood of good treatment response, irrespective of the type of randomised treatment received.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Treatment; Rheumatoid Arthritis; Risk Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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Dubovyk, Violett ...
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Vasileiadis, Geo ...
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Fatima, Tahzeeb
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Zhang, Yuan
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Kapetanovic, Mel ...
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Kastbom, Alf
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Rizk, Milad
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Soederbergh, Ann ...
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Zhao, Sizheng St ...
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van Vollenhoven, ...
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Hetland, Merete ...
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Haavardsholm, Es ...
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Nordstrom, Dan
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Nurmohamed, Mich ...
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Gudbjornsson, Bj ...
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Lampa, Jon
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Ostergaard, Mikk ...
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Heiberg, Marte S ...
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Sokka-Isler, Tuu ...
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Grondal, Gerdur
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Lend, Kristina
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Horslev-Petersen ...
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Uhlig, Till
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Rudin, Anna
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Maglio, Cristina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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RMD Open
- By the university
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Linköping University
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Karolinska Institutet