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Multiple spatial sc...
Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis
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- Fanton, Silvia (författare)
- Karolinska Institutet
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- Altawil, Reem (författare)
- Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Rheumatol Unit, Stockholm, Sweden.
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- Ellerbrock, Isabel (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.
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- Lampa, Jon (författare)
- Karolinska Institutet
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- Kosek, Eva (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden.
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- Fransson, Peter (författare)
- Karolinska Institutet
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- Thompson, William Hedley, 1987 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för tillämpad informationsteknologi (GU),Department of Applied Information Technology (GU),Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Univ Gothenburg, Dept Appl IT, Div Cognit & Commun, Gothenburg, Sweden.
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Karolinska Institutet Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Rheumatol Unit, Stockholm, Sweden (creator_code:org_t)
- 2022-08-09
- 2022
- Engelska.
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Ingår i: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 16
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Functional brain networks and the perception of pain can fluctuate over time. However, how the time-dependent reconfiguration of functional brain networks contributes to chronic pain remains largely unexplained. Here, we explored time-varying changes in brain network integration and segregation during pain over a disease-affected area (joint) compared to a neutral site (thumbnail) in 28 patients with rheumatoid arthritis (RA) in comparison with 22 healthy controls (HC). During functional magnetic resonance imaging, all subjects received individually calibrated pain pressures corresponding to visual analog scale 50 mm at joint and thumbnail. We implemented a novel approach to track changes of task-based network connectivity over time. Within this framework, we quantified measures of integration (participation coefficient, PC) and segregation (within-module degree z-score). Using these network measures at multiple spatial scales, both at the level of single nodes (brain regions) and communities (clusters of nodes), we found that PC at the community level was generally higher in RA patients compared to HC during and after painful pressure over the inflamed joint and corresponding site in HC. This shows that all brain communities integrate more in RA patients than in HC for time points following painful stimulation to a disease-relevant body site. However, the elevated community-related integration seen in patients appeared to not pertain uniquely to painful stimulation at the inflamed joint, but also at the neutral thumbnail, as integration and segregation at the community level did not differ across body sites in patients. Moreover, there was no specific nodal contribution to brain network integration or segregation. Altogether, our findings indicate widespread and persistent changes in network interaction in RA patients compared to HC in response to painful stimulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Clinical Science (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
Nyckelord
- brain networks
- chronic pain
- fMRI
- rheumatoid arthritis
- temporal network theory
- time-varying functional connectivity
- fMRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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