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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

Conde, Lucia (author)
Halperin, Eran (author)
Akers, Nicholas K. (author)
show more...
Brown, Kevin M. (author)
Smedby, Karin E. (author)
Karolinska Institutet
Rothman, Nathaniel (author)
Nieters, Alexandra (author)
Slager, Susan L. (author)
Brooks-Wilson, Angela (author)
Agana, Luz (author)
Riby, Jacques (author)
Liu, Jianjun (author)
Adami, Hans-Olov (author)
Karolinska Institutet
Darabi, Hatef (author)
Karolinska Institutet
Hjalgrim, Henrik (author)
Low, Hui-Qi (author)
Humphreys, Keith (author)
Karolinska Institutet
Melbye, Mads (author)
Chang, Ellen T. (author)
Glimelius, Bengt (author)
Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
Cozen, Wendy (author)
Davis, Scott (author)
Hartge, Patricia (author)
Morton, Lindsay M. (author)
Schenk, Maryjean (author)
Wang, Sophia S. (author)
Armstrong, Bruce (author)
Kricker, Anne (author)
Milliken, Sam (author)
Purdue, Mark P. (author)
Vajdic, Claire M. (author)
Boyle, Peter (author)
Lan, Qing (author)
Zahm, Shelia H. (author)
Zhang, Yawei (author)
Zheng, Tongzhang (author)
Becker, Nikolaus (author)
Benavente, Yolanda (author)
Boffetta, Paolo (author)
Brennan, Paul (author)
Butterbach, Katja (author)
Cocco, Pierluigi (author)
Foretova, Lenka (author)
Maynadie, Marc (author)
de Sanjose, Silvia (author)
Staines, Anthony (author)
Spinelli, John J. (author)
Achenbach, Sara J. (author)
Call, Timothy G. (author)
Camp, Nicola J. (author)
Glenn, Martha (author)
Caporaso, Neil E. (author)
Cerhan, James R. (author)
Cunningham, Julie M. (author)
Goldin, Lynn R. (author)
Hanson, Curtis A. (author)
Kay, Neil E. (author)
Lanasa, Mark C. (author)
Leis, Jose F. (author)
Marti, Gerald E. (author)
Rabe, Kari G. (author)
Rassenti, Laura Z. (author)
Spector, Logan G. (author)
Strom, Sara S. (author)
Vachon, Celine M. (author)
Weinberg, J. Brice (author)
Holly, Elizabeth A. (author)
Chanock, Stephen (author)
Smith, Martyn T. (author)
Bracci, Paige M. (author)
Skibola, Christine F. (author)
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 (creator_code:org_t)
2010-07-18
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:8, s. 661-664
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

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