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The CRCbiome study:...
The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
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- Kvaerner, A. S. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Birkeland, E. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Bucher-Johannessen, C. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Vinberg, E. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Nordby, J. I. (författare)
- Oslo universitetssykehus,Oslo University Hospital
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- Kangas, H. (författare)
- Helsingin Yliopisto,University of Helsinki
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- Bemanian, V. (författare)
- Akershus University Hospital
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- Ellonen, P. (författare)
- Helsingin Yliopisto,University of Helsinki
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- Botteri, E. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Natvig, E. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Rognes, T. (författare)
- Oslo universitetssykehus,Oslo University Hospital,Universitetet i Oslo,University of Oslo
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- Hovig, E. (författare)
- Universitetet i Oslo,University of Oslo
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- Lyle, R. (författare)
- Oslo universitetssykehus,Oslo University Hospital,Norwegian Institute of Public Health
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- Ambur, O. H. (författare)
- Akershus University Hospital,Høgskolen i Oslo og Akershus (HiOA),Oslo and Akerhus University of Applied Sciences
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- de Vos, W. M. (författare)
- Wageningen University and Research,Helsingin Yliopisto,University of Helsinki
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- Bultman, S. (författare)
- The University of North Carolina,The University of North Carolina System
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- Hjartaker, A. (författare)
- Universitetet i Oslo,University of Oslo
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Song, M. Y. (författare)
- Harvard School of Public Health, United States,Massachusetts General Hospital
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- Blix, H. S. (författare)
- Norwegian Institute of Public Health,Universitetet i Oslo,University of Oslo
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- Ursin, G. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Randel, K. R. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- de Lange, Thomas, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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- Hoff, G. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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Holme, O. (författare)
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- Berstad, P. (författare)
- Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Rounge, T. B. (författare)
- Universitetet i Oslo,University of Oslo,Cancer Registry of Norway Institute of Population-Based Cancer Research
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- Holme, Øyvind (författare)
- Universitetet i Oslo,University of Oslo,Cancer Registry of Norway Institute of Population-Based Cancer Research
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(creator_code:org_t)
- 2021-08-18
- 2021
- Engelska.
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Ingår i: Bmc Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 21:1
- Relaterad länk:
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https://bmccancer.bi...
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https://research.cha... (primary) (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Background: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary screening methods. To aid in the development of a non-invasive screening test with improved sensitivity and specificity, we have initiated a prospective biomarker study (CRCbiome), nested within a large randomized CRC screening trial in Norway. We aim to develop a microbiome-based classification algorithm to identify advanced colorectal lesions in screening participants testing positive for an immunochemical fecal occult blood test (FIT). We will also examine interactions with host factors, diet, lifestyle and prescription drugs. The prospective nature of the study also enables the analysis of changes in the gut microbiome following the removal of precancerous lesions. Methods: The CRCbiome study recruits participants enrolled in the Bowel Cancer Screening in Norway (BCSN) study, a randomized trial initiated in 2012 comparing once-only sigmoidoscopy to repeated biennial FIT, where women and men aged 50-74 years at study entry are invited to participate. Since 2017, participants randomized to FIT screening with a positive test result have been invited to join the CRCbiome study. Self-reported diet, lifestyle and demographic data are collected prior to colonoscopy after the positive FIT-test (baseline). Screening data, including colonoscopy findings are obtained from the BCSN database. Fecal samples for gut microbiome analyses are collected both before and 2 and 12 months after colonoscopy. Samples are analyzed using metagenome sequencing, with taxonomy profiles, and gene and pathway content as primary measures. CRCbiome data will also be linked to national registries to obtain information on prescription histories and cancer relevant outcomes occurring during the 10 year follow-up period. Discussion: The CRCbiome study will increase our understanding of how the gut microbiome, in combination with lifestyle and environmental factors, influences the early stages of colorectal carcinogenesis. This knowledge will be crucial to develop microbiome-based screening tools for CRC. By evaluating biomarker performance in a screening setting, using samples from the target population, the generalizability of the findings to future screening cohorts is likely to be high.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Diet
- Lifestyle
- Prescription drugs
- Gut microbiome
- Metagenomics
- sequencing
- Biomarkers
- Screening
- FIT
- iFOBT
- Colonoscopy
- Adenoma
- Colorectal cancer
- Advanced neoplasia
- food-frequency questionnaire
- randomized controlled-trial
- follow-up
- sigmoidoscopy
- validation
- biomarkers
- mortality
- patterns
- risk
- Oncology
- Prescription drugs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kvaerner, A. S.
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Birkeland, E.
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Bucher-Johanness ...
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Vinberg, E.
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Nordby, J. I.
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Kangas, H.
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visa fler...
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Bemanian, V.
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Ellonen, P.
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Botteri, E.
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Natvig, E.
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Rognes, T.
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Hovig, E.
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Lyle, R.
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Ambur, O. H.
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de Vos, W. M.
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Bultman, S.
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Hjartaker, A.
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Landberg, Rikard ...
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Song, M. Y.
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Blix, H. S.
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Ursin, G.
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Randel, K. R.
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de Lange, Thomas ...
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Hoff, G.
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Holme, O.
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Berstad, P.
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Rounge, T. B.
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Holme, Øyvind
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Bmc Cancer
- Av lärosätet
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Göteborgs universitet
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Chalmers tekniska högskola