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Gene-centric meta-a...
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations
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Yoneyama, Sachiko (author)
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Guo, Yiran (author)
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Lanktree, Matthew B. (author)
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show more...
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Barnes, Michael R. (author)
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Elbers, Clara C. (author)
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Karczewski, Konrad J. (author)
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Padmanabhan, Sandosh (author)
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Bauer, Florianne (author)
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Baumert, Jens (author)
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Beitelshees, Amber (author)
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Berenson, Gerald S. (author)
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Boer, Jolanda M. A. (author)
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Burke, Gregory (author)
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Cade, Brian (author)
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Chen, Wei (author)
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Cooper-Dehoff, Rhonda M. (author)
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Gaunt, Tom R. (author)
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Gieger, Christian (author)
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Gong, Yan (author)
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Gorski, Mathias (author)
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Heard-Costa, Nancy (author)
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Johnson, Toby (author)
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Lamonte, Michael J. (author)
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Mcdonough, Caitrin (author)
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Monda, Keri L. (author)
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Onland-Moret, N. Charlotte (author)
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Nelson, Christopher P. (author)
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O'Connell, Jeffrey R. (author)
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Ordovas, Jose (author)
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Peter, Inga (author)
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Peters, Annette (author)
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Shaffer, Jonathan (author)
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Shen, Haiqinq (author)
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Smith, Erin (author)
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Speilotes, Liz (author)
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Thomas, Fridtjof (author)
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Thorand, Barbara (author)
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Verschuren, W. M. Monique (author)
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Anand, Sonia S. (author)
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Dominiczak, Anna (author)
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Davidson, Karina W. (author)
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Hegele, Robert A. (author)
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Heid, Iris (author)
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Hofker, Marten H. (author)
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Huggins, Gordon S. (author)
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Illig, Thomas (author)
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Johnson, Julie A. (author)
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Kirkland, Susan (author)
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Koenig, Wolfgang (author)
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Langaee, Taimour Y. (author)
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Mccaffery, Jeanne (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Mitchell, Braxton D. (author)
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Munroe, Patricia (author)
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Murray, Sarah S. (author)
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Papanicolaou, George (author)
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Redline, Susan (author)
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Reilly, Muredach (author)
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Samani, Nilesh J. (author)
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Schork, Nicholas J. (author)
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Van der Schouw, Yvonne T. (author)
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Shimbo, Daichi (author)
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Shuldiner, Alan R. (author)
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Tobin, Martin D. (author)
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Wijmenga, Cisca (author)
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Yusuf, Salim (author)
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Hakonarson, Hakon (author)
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Lange, Leslie A. (author)
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Demerath, Ellen W. (author)
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Fox, Caroline S. (author)
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North, Kari E. (author)
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Reiner, Alex P. (author)
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Keating, Brendan (author)
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Taylor, Kira C. (author)
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(creator_code:org_t)
- 2013-12-17
- 2014
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:9, s. 2498-2510
- Related links:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to 57 412 individuals of European descent from 22 cohorts collaborating with the NHLBIs Candidate Gene Association Resource (CARe) project. The study population consisted of women and men aged 2080 years. Study participants were genotyped using the ITMAT/Broad/CARE array, which includes 50 000 cosmopolitan tagged SNPs across 2100 cardiovascular-related genes. Each trait was modeled as a function of age, study site and principal components to control for population stratification, and we conducted a fixed-effects meta-analysis. No new loci for WC were observed. For WHR analyses, three novel loci were significantly associated (P 2.4 10(6)). Previously unreported rs2811337-G near TMCC1 was associated with increased WHR ( SE, 0.048 0.008, P 7.7 10(9)) as was rs7302703-G in HOXC10 ( 0.044 0.008, P 2.9 10(7)) and rs936108-C in PEMT ( 0.035 0.007, P 1.9 10(6)). Sex-stratified analyses revealed two additional novel signals among females only, rs12076073-A in SHC1 ( 0.10 0.02, P 1.9 10(6)) and rs1037575-A in ATBDB4 ( 0.046 0.01, P 2.2 10(6)), supporting an already established sexual dimorphism of central adiposity-related genetic variants. Functional analysis using ENCODE and eQTL databases revealed that several of these loci are in regulatory regions or regions with differential expression in adipose tissue.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Yoneyama, Sachik ...
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Guo, Yiran
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Lanktree, Matthe ...
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Barnes, Michael ...
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Elbers, Clara C.
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Karczewski, Konr ...
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show more...
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Padmanabhan, San ...
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Bauer, Florianne
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Baumert, Jens
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Beitelshees, Amb ...
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Berenson, Gerald ...
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Boer, Jolanda M. ...
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Burke, Gregory
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Cade, Brian
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Chen, Wei
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Cooper-Dehoff, R ...
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Gaunt, Tom R.
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Gieger, Christia ...
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Gong, Yan
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Gorski, Mathias
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Heard-Costa, Nan ...
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Johnson, Toby
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Lamonte, Michael ...
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Mcdonough, Caitr ...
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Monda, Keri L.
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Onland-Moret, N. ...
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Nelson, Christop ...
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O'Connell, Jeffr ...
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Ordovas, Jose
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Peter, Inga
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Peters, Annette
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Shaffer, Jonatha ...
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Shen, Haiqinq
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Smith, Erin
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Speilotes, Liz
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Thomas, Fridtjof
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Thorand, Barbara
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Verschuren, W. M ...
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Anand, Sonia S.
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Dominiczak, Anna
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Davidson, Karina ...
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Hegele, Robert A ...
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Heid, Iris
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Hofker, Marten H ...
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Huggins, Gordon ...
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Illig, Thomas
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Johnson, Julie A ...
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Kirkland, Susan
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Koenig, Wolfgang
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Langaee, Taimour ...
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Mccaffery, Jeann ...
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Melander, Olle
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Mitchell, Braxto ...
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Munroe, Patricia
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Murray, Sarah S.
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Papanicolaou, Ge ...
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Redline, Susan
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Reilly, Muredach
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Samani, Nilesh J ...
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Schork, Nicholas ...
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Van der Schouw, ...
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Shimbo, Daichi
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Shuldiner, Alan ...
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Tobin, Martin D.
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Wijmenga, Cisca
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Yusuf, Salim
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Hakonarson, Hako ...
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Lange, Leslie A.
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Demerath, Ellen ...
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Fox, Caroline S.
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North, Kari E.
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Reiner, Alex P.
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Keating, Brendan
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Taylor, Kira C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Lund University