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Sökning: onr:"swepub:oai:DiVA.org:uu-306775" > Combined effects of...

Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena (författare)
Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization
Muller, David C. (författare)
Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization,University of Padova
Lagiou, Pagona (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece.
visa fler...
Ahrens, Wolfgang (författare)
BIPS, Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany.;Univ Bremen, Fac Math & Comp Sci, Bremen, Germany.,Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH
Holcatova, Ivana (författare)
Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague, Czech Republic.,Charles University in Prague
Merletti, Franco (författare)
Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy.,University of Turin
Kjaerheim, Kristina (författare)
Canc Registry Norway, Oslo, Norway.,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Polesel, Jerry (författare)
CRO Aviano Natl Canc Inst, Unit Epidemiol & Biostat, Aviano, Italy.,CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute
Simonato, Lorenzo (författare)
Univ Padua, Dept Mol Med, Lab Publ Hlth & Populat Studies, Padua, Italy.,University of Padova
Canova, Cristina (författare)
Univ Padua, Dept Mol Med, Lab Publ Hlth & Populat Studies, Padua, Italy.
Castellsague, Xavier (författare)
CIBERESP, IDIBELL, ICO, Unit Infect & Canc, Barcelona, Spain.,L'Hospitalet de Llobregat, Barcelona
Macfarlane, Tatiana V. (författare)
Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland.,University of Aberdeen
Znaor, Ariana (författare)
Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia.;Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France.,Croatian National Institute of Public Health, Zagreb
Thomson, Peter (författare)
Newcastle Univ, Ctr Oral Hlth Res, Newcastle Upon Tyne, Tyne & Wear, England.,University of Newcastle upon Tyne
Robinson, Max (författare)
Newcastle Univ, Ctr Oral Hlth Res, Newcastle Upon Tyne, Tyne & Wear, England.,University of Newcastle upon Tyne
Conway, David I. (författare)
Univ Glasgow, Sch Dent, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.,University of Glasgow
Healy, Claire M. (författare)
Trinity Coll Dublin, Sch Dent Sci, Dublin, Ireland.,Trinity College Dublin
Tjönneland, Anne (författare)
Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark.,Danish Cancer Society
Westin, Ulla (författare)
Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups
Ekström, Johanna (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Klinisk mikrobiologi, Malmö,Internal Medicine - Epidemiology,Lund University Research Groups,Clinical Microbiology, Malmö
Chang-Claude, Jenny (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
Kaaks, Rudolf (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.,German Cancer Research Centre
Overvad, Kim (författare)
Inst Publ Hlth, Aarhus, Denmark.,Aarhus University
Drogan, Dagmar (författare)
German Inst Human Nutr Potsdam Rehbruecke DIfE, Nuthetal, Germany.,German Institute of Human Nutrition
Hallmans, Göran (författare)
Umeå University,Umeå universitet,Enheten för biobanksforskning
Laurell, Göran (författare)
Uppsala University,Uppsala universitet,Öron-, näs- och halssjukdomar
Bueno-de-Mesquita, H. B. (författare)
Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.
Peeters, Petra H. (författare)
Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands.;Imperial Coll London, Sch Publ Hlth, MRC PHE, London, England.
Agudo, Antonio (författare)
ICO, Unit Nutr & Canc, Barcelona, Spain.,L'Hospitalet de Llobregat, Barcelona
Larranaga, Nerea (författare)
BIODonostia Res Inst, Basque Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain.;CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
Travis, Ruth C. (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Palli, Domenico (författare)
Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy.
Barricarte, Aurelio (författare)
CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Navarre Publ Hlth Inst, Pamplona, Spain.,CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
Trichopoulou, Antonia (författare)
Hellen Hlth Fdn, Athens, Greece.;Acad Athens, Bur Epidemiol Res, Athens, Greece.,Academy of Athens
George, Saitakis (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece.;Hellen Hlth Fdn, Athens, Greece.,National and Kapodistrian University of Athens
Trichopoulos, Dimitrios (författare)
Hellen Hlth Fdn, Athens, Greece.;Acad Athens, Bur Epidemiol Res, Athens, Greece.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.,Harvard University,Academy of Athens
Ramon Quiros, J. (författare)
Publ Hlth Directorate Asturias, Oviedo, Spain.
Grioni, Sara (författare)
Fdn IRCCS, Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy.,Istituto Nazionale dei Tumori
Sacerdote, Carlotta (författare)
Univ Turin, Citta Salute & Sci Hosp, Canc Epidemiol Unit, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.,Centre for Cancer Epidemiology and Prevention (CPO Piemonte)
Navarro, Carmen (författare)
CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
Sanchez, Maria-Jose (författare)
CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.;Univ Granada, Inst Invest Biosanitaria, Granada, Spain.,University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
Tumino, Rosario (författare)
Civ MP Arezzo Hosp, Canc Registry, Asp Ragusa, Ragusa, Italy.;Civ MP Arezzo Hosp, Histopathol Unit, Asp Ragusa, Ragusa, Italy.
Severi, Gianluca (författare)
Human Genet Fdn HuGeF, Turin, Italy.;Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.,University of Melbourne,Human Genetics Foundation (HuGeF)
Boutron-Ruault, Marie-Christine (författare)
INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France.;Univ Paris 11, Villejuif, France.;Inst Gustave Roussy, Villejuif, France.,University of Paris-Saclay
Clavel-Chapelon, Francoise (författare)
INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France.;Univ Paris 11, Villejuif, France.;Inst Gustave Roussy, Villejuif, France.
Panico, Salvatore (författare)
Univ Naples Federico II, Dipartimento Med Clin & Chirurgia, Naples, Italy.,University of Naples Federico II
Weiderpass, Elisabete (författare)
Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
Lund, Eiliv (författare)
Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø
Gram, Inger T. (författare)
Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø
Riboli, Elio (författare)
Imperial Coll London, Sch Publ Hlth, London, England.,Imperial College London
Pawlita, Michael (författare)
German Canc Res Ctr, Heidelberg, Germany.,German Cancer Research Centre
Waterboer, Tim (författare)
German Canc Res Ctr, Heidelberg, Germany.,German Cancer Research Centre
Kreimer, Aimee R. (författare)
NCI, NIH, Bethesda, MD 20892 USA.,National Cancer Institute, NCI
Johansson, Mattias (författare)
Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, World Health Organization
Brennan, Paul (författare)
Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France.,International Agency for Research on Cancer, World Health Organization
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Int Agcy Res Canc, Genet Epidemiol Grp, Lyon, France International Agency for Research on Cancer, World Health Organization (creator_code:org_t)
2016-05-19
2016
Engelska.
Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 45:3, s. 752-761
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Human papillomavirus
tobacco smoking
interaction
head and neck cancer risk
oropharynx cancer
Journal Article

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ref (ämneskategori)
art (ämneskategori)

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