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Præoperativ funktio...
Præoperativ funktionel magnetisk resonans-billeddannelse hos patienter med hjernetumor
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Laustsen, Søren Ravn (författare)
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Sørensen, Preben (författare)
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Fründ, Torben (författare)
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visa fler...
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Larsson, Henrik B. W. (författare)
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Christensen, Thorkil (författare)
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Enheten för radiologi
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visa färre...
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(creator_code:org_t)
- 2010
- 2010
- Danska.
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Ingår i: Ugeskrift for læger. - 0041-5782 .- 1603-6824. ; 172:35, s. 2370-2376
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- INTRODUCTION: Functional Magnetic Resonance Imaging (fMRI) allows important functions in the brain cortex to be mapped noninvasively. The purpose with this work was to investigate a possible correlation between the distance from the tumour margin to fMRI activity and postoperative neurological deficits by means of a standardised method for measurement of distance. A second purpose was to investigate the influence of preoperative fMRI on the neurosurgical decision-making process. MATERIAL AND METHODS: Retrospective study of 25 patients. The inclusion criteria were surgery or biopsy after fMRI plus a three-month postoperative assessment. A total of 14 patients complied with these requirements (six men and eight women, the mean age was 39 years). fMRI raw data was collected using a three tesla magnetic resonance scanner (Signa HDx R14M5, GE Healthcare). The distance from the tumour margin to fMRI activation was measured using GE-reformat version 4.2 after raw data had been postprocessed using GE BrainwavePA version 1.3.08130. The neurosurgeons valuation of fMRI in the preoperative decision-making process was obtained using a standard questionnaire. RESULTS: There was a trend of association between distance from tumour to eloquent functional areas and the patients' postoperative neurological outcome (Fisher's exact test: distance < 15 mm, p = 0.43; distance < 10 mm, p = 0.14). fMRI proved very useful when deciding whether to operate or not (42%), when deciding the surgical approach (50%) and when deciding the extent of the surgical approach (83%). CONCLUSION: The standardised method for measurement of distance between tumour margin and fMRI activity can contribute to the preoperative risk assessment in patients with brain tumours.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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