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Optimal timing of i...
Optimal timing of influenza vaccination among patients with acute myocardial infarction - Findings from the IAMI trial
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- Akhtar, Zubair (författare)
- Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh
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- Götberg, Matthias (författare)
- Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden
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- Erlinge, David (författare)
- Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden
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- Christiansen, Evald H. (författare)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- Oldroyd, Keith G. (författare)
- Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom,Univ Glasgow, Scotland
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- Motovska, Zuzana (författare)
- Cardiocenter, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic,Charles Univ Prague, Czech Republic; Univ Hosp Kralovske Vinohrady, Czech Republic
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- Erglis, Andrejs (författare)
- Pauls Stradins Clinical University Hospital, University of Latvia, Riga, Latvia,Univ Latvia, Latvia
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- Hlinomaz, Ota (författare)
- International Clinical Research Center, St. Anne University Hospital and Masaryk University, Brno, Czech Republic,St Anne Univ Hosp, Czech Republic; Masaryk Univ, Czech Republic
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- Jakobsen, Lars (författare)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- Engstrøm, Thomas (författare)
- Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark
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- Jensen, Lisette O. (författare)
- Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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- Fallesen, Christian O. (författare)
- Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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- Jensen, Svend E (författare)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Aalborg Univ, Denmark
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- Angerås, Oskar, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Calais, Fredrik, 1971- (författare)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden,Orebro Univ, Sweden
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- Kåregren, Amra (författare)
- Västmanlands sjukhus Västerås, Västerås, Sweden
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- Lauermann, Jörg (författare)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Reg Jonkoping Cty, Sweden
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- Mokhtari, Arash (författare)
- Department of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden
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- Nilsson, Johan (författare)
- Umeå universitet,Kardiologi,Umea Univ, Sweden
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- Persson, Jonas (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Islam, Abu K. M. M. (författare)
- National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh
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- Rahman, Afzalur (författare)
- National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh
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- Malik, Fazila (författare)
- National Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh
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- Choudhury, Sohel (författare)
- National Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh
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- Collier, Timothy (författare)
- Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England
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- Pocock, Stuart J. (författare)
- Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England
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- Pernow, John (författare)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- MacIntyre, Chandini R. (författare)
- Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden,Univ New South Wales, Australia; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, USA; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, AZ, Tempe, United States; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Orebro Univ, Sweden; Arizona State Univ, AZ USA; Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Vaccine. - : Elsevier. - 0264-410X .- 1873-2518. ; 41:48, s. 7159-7165
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Influenza vaccination reduces the risk of adverse cardiovascular events. The IAMI trial randomly assigned 2571 patients with acute myocardial infarction (AMI) to receive influenza vaccine or saline placebo during their index hospital admission. It was conducted at 30 centers in 8 countries from October 1, 2016 to March 1, 2020. In this post-hoc exploratory sub-study, we compare the trial outcomes in patients receiving early season vaccination (n = 1188) and late season vaccination (n = 1344). The primary endpoint was the composite of all-cause death, myocardial infarction (MI), or stent thrombosis at 12 months. The cumulative incidence of the primary and key secondary endpoints by randomized treatment and early or late vaccination was estimated using the Kaplan-Meier method. In the early vaccinated group, the primary composite endpoint occurred in 36 participants (6.0%) assigned to influenza vaccine and 49 (8.4%) assigned to placebo (HR 0.69; 95% CI 0.45 to 1.07), compared to 31 participants (4.7%) assigned to influenza vaccine and 42 (6.2%) assigned to placebo (HR 0.74; 95% CI 0.47 to 1.18) in the late vaccinated group (P = 0.848 for interaction on HR scale at 1 year). We observed similar estimates for the key secondary endpoints of all-cause death and CV death. There was no statistically significant difference in vaccine effectiveness against adverse cardiovascular events by timing of vaccination. The effect of vaccination on all-cause death at one year was more pronounced in the group receiving early vaccination (HR 0.50; 95% CI, 0.29 to 0.86) compared late vaccination group (HR 0.75; 35% CI, 0.40 to 1.40) but there was no statistically significant difference between these groups (Interaction P = 0.335). In conclusion, there is insufficient evidence from the trial to establish whether there is a difference in efficacy between early and late vaccination but regardless of vaccination timing we strongly recommend influenza vaccination in all patients with cardiovascular diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- Influenza vaccination
- Myocardial infarction
- Optimal timing
- Percutaneous coronary intervention
- Vaccine effectiveness
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Vaccine
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Akhtar, Zubair
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Götberg, Matthia ...
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Erlinge, David
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Christiansen, Ev ...
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Oldroyd, Keith G ...
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Motovska, Zuzana
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visa fler...
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Erglis, Andrejs
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Hlinomaz, Ota
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Jakobsen, Lars
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Engstrøm, Thomas
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Jensen, Lisette ...
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Fallesen, Christ ...
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Jensen, Svend E
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Angerås, Oskar, ...
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Calais, Fredrik, ...
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Kåregren, Amra
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Lauermann, Jörg
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Mokhtari, Arash
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Nilsson, Johan
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Persson, Jonas
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Islam, Abu K. M. ...
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Rahman, Afzalur
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Malik, Fazila
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Choudhury, Sohel
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Collier, Timothy
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Pocock, Stuart J ...
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Pernow, John
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MacIntyre, Chand ...
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Fröbert, Ole, 19 ...
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