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Individual common variants exert weak effects on the risk for autism spectrum disorders.

Anney, Richard (author)
Klei, Lambertus (author)
Pinto, Dalila (author)
show more...
Almeida, Joana (author)
Bacchelli, Elena (author)
Baird, Gillian (author)
Bolshakova, Nadia (author)
Bölte, Sven (author)
Bolton, Patrick F. (author)
Bourgeron, Thomas (author)
Brennan, Sean (author)
Brian, Jessica (author)
Casey, Jillian (author)
Conroy, Judith (author)
Correia, Catarina (author)
Corsello, Christina (author)
Crawford, Emily L (author)
de Jonge, Maretha (author)
Delorme, Richard (author)
Duketis, Eftichia (author)
Duque, Frederico (author)
Estes, Annette (author)
Farrar, Penny (author)
Fernandez, Bridget A (author)
Folstein, Susan E (author)
Fombonne, Eric (author)
Gilbert, John (author)
Gillberg, Christopher, 1950 (author)
Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
Glessner, Joseph T (author)
Green, Andrew (author)
Green, Jonathan (author)
Guter, Stephen J (author)
Heron, Elizabeth A (author)
Holt, Richard (author)
Howe, Jennifer L (author)
Hughes, Gillian (author)
Hus, Vanessa (author)
Igliozzi, Roberta (author)
Jacob, Suma (author)
Kenny, Graham P (author)
Kim, Cecilia (author)
Kolevzon, Alexander (author)
Kustanovich, Vlad (author)
Lajonchere, Clara M (author)
Lamb, Janine A (author)
Law-Smith, Miriam (author)
Leboyer, Marion (author)
Le Couteur, Ann (author)
Leventhal, Bennett L (author)
Liu, Xiao-Qing (author)
Lombard, Frances (author)
Lord, Catherine (author)
Lotspeich, Linda (author)
Lund, Sabata C (author)
Magalhaes, Tiago R (author)
Mantoulan, Carine (author)
McDougle, Christopher J (author)
Melhem, Nadine M (author)
Merikangas, Alison (author)
Minshew, Nancy J (author)
Mirza, Ghazala K (author)
Munson, Jeff (author)
Noakes, Carolyn (author)
Nygren, Gudrun, 1957 (author)
Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
Papanikolaou, Katerina (author)
Pagnamenta, Alistair T (author)
Parrini, Barbara (author)
Paton, Tara (author)
Pickles, Andrew (author)
Posey, David J (author)
Poustka, Fritz (author)
Ragoussis, Jiannis (author)
Regan, Regina (author)
Renshaw, Katy (author)
Roberts, Wendy (author)
Roeder, Kathryn (author)
Roge, Bernadette (author)
Rutter, Michael L (author)
Schlitt, Sabine (author)
Shah, Naisha (author)
Sheffield, Val C (author)
Soorya, Latha (author)
Sousa, Inês (author)
Stoppioni, Vera (author)
Sykes, Nuala (author)
Tancredi, Raffaella (author)
Thompson, Ann P (author)
Thomson, Susanne (author)
Tryfon, Ana (author)
Tsiantis, John (author)
Van Engeland, Herman (author)
Vincent, John B (author)
Vorstman, Jas (author)
Volkmar, Fred (author)
Wallace, Simon (author)
Wing, Kirsty (author)
Wood, Shawn (author)
Wittemeyer, Kerstin (author)
Zurawiecki, Danielle (author)
Zwaigenbaum, Lonnie (author)
Bailey, Anthony J (author)
Battaglia, Agatino (author)
Cantor, Rita M (author)
Coon, Hilary (author)
Cuccaro, Michael L (author)
Dawson, Geraldine (author)
Ennis, Sean (author)
Freitag, Christine M (author)
Geschwind, Daniel H (author)
Haines, Jonathan L (author)
Klauck, Sabine M (author)
McMahon, William M (author)
Maestrini, Elena (author)
Miller, Judith (author)
Monaco, Anthony P (author)
Nelson, Stanley F (author)
Nurnberger, John I (author)
Oliveira, Guiomar (author)
Parr, Jeremy R (author)
Pericak-Vance, Margaret A (author)
Piven, Joseph (author)
Schellenberg, Gerard D (author)
Scherer, Stephen W (author)
Vicente, Astrid M (author)
Wassink, Thomas H (author)
Wijsman, Ellen M (author)
Betancur, Catalina (author)
Buxbaum, Joseph D (author)
Cook, Edwin H (author)
Gallagher, Louise (author)
Gill, Michael (author)
Hallmayer, Joachim (author)
Paterson, Andrew D (author)
Sutcliffe, James S (author)
Szatmari, Peter (author)
Vieland, Veronica J (author)
Hakonarson, Hakon (author)
Devlin, Bernie (author)
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 (creator_code:org_t)
2012-07-26
2012
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:21, s. 4781-92
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASD), the contribution of common variation to ASD risk is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating association of individual SNPs, we also sought evidence that common variants, en masse, might affect risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest p-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. By contrast, allele-scores derived from the transmission of common alleles to Stage 1 cases significantly predict case-status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele-score results, it is reasonable to conclude that common variants affect ASD risk but their individual effects are modest.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

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art (subject category)

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By the author/editor
Anney, Richard
Klei, Lambertus
Pinto, Dalila
Almeida, Joana
Bacchelli, Elena
Baird, Gillian
show more...
Bolshakova, Nadi ...
Bölte, Sven
Bolton, Patrick ...
Bourgeron, Thoma ...
Brennan, Sean
Brian, Jessica
Casey, Jillian
Conroy, Judith
Correia, Catarin ...
Corsello, Christ ...
Crawford, Emily ...
de Jonge, Mareth ...
Delorme, Richard
Duketis, Eftichi ...
Duque, Frederico
Estes, Annette
Farrar, Penny
Fernandez, Bridg ...
Folstein, Susan ...
Fombonne, Eric
Gilbert, John
Gillberg, Christ ...
Glessner, Joseph ...
Green, Andrew
Green, Jonathan
Guter, Stephen J
Heron, Elizabeth ...
Holt, Richard
Howe, Jennifer L
Hughes, Gillian
Hus, Vanessa
Igliozzi, Robert ...
Jacob, Suma
Kenny, Graham P
Kim, Cecilia
Kolevzon, Alexan ...
Kustanovich, Vla ...
Lajonchere, Clar ...
Lamb, Janine A
Law-Smith, Miria ...
Leboyer, Marion
Le Couteur, Ann
Leventhal, Benne ...
Liu, Xiao-Qing
Lombard, Frances
Lord, Catherine
Lotspeich, Linda
Lund, Sabata C
Magalhaes, Tiago ...
Mantoulan, Carin ...
McDougle, Christ ...
Melhem, Nadine M
Merikangas, Alis ...
Minshew, Nancy J
Mirza, Ghazala K
Munson, Jeff
Noakes, Carolyn
Nygren, Gudrun, ...
Papanikolaou, Ka ...
Pagnamenta, Alis ...
Parrini, Barbara
Paton, Tara
Pickles, Andrew
Posey, David J
Poustka, Fritz
Ragoussis, Jiann ...
Regan, Regina
Renshaw, Katy
Roberts, Wendy
Roeder, Kathryn
Roge, Bernadette
Rutter, Michael ...
Schlitt, Sabine
Shah, Naisha
Sheffield, Val C
Soorya, Latha
Sousa, Inês
Stoppioni, Vera
Sykes, Nuala
Tancredi, Raffae ...
Thompson, Ann P
Thomson, Susanne
Tryfon, Ana
Tsiantis, John
Van Engeland, He ...
Vincent, John B
Vorstman, Jas
Volkmar, Fred
Wallace, Simon
Wing, Kirsty
Wood, Shawn
Wittemeyer, Kers ...
Zurawiecki, Dani ...
Zwaigenbaum, Lon ...
Bailey, Anthony ...
Battaglia, Agati ...
Cantor, Rita M
Coon, Hilary
Cuccaro, Michael ...
Dawson, Geraldin ...
Ennis, Sean
Freitag, Christi ...
Geschwind, Danie ...
Haines, Jonathan ...
Klauck, Sabine M
McMahon, William ...
Maestrini, Elena
Miller, Judith
Monaco, Anthony ...
Nelson, Stanley ...
Nurnberger, John ...
Oliveira, Guioma ...
Parr, Jeremy R
Pericak-Vance, M ...
Piven, Joseph
Schellenberg, Ge ...
Scherer, Stephen ...
Vicente, Astrid ...
Wassink, Thomas ...
Wijsman, Ellen M
Betancur, Catali ...
Buxbaum, Joseph ...
Cook, Edwin H
Gallagher, Louis ...
Gill, Michael
Hallmayer, Joach ...
Paterson, Andrew ...
Sutcliffe, James ...
Szatmari, Peter
Vieland, Veronic ...
Hakonarson, Hako ...
Devlin, Bernie
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
Human Molecular ...
By the university
University of Gothenburg

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