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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

Hou, Liping (author)
Bergen, Sarah E (author)
Karolinska Institutet
Akula, Nirmala (author)
show more...
Song, Jie (author)
Karolinska Institutet
Hultman, Christina M (author)
Karolinska Institutet
Landén, Mikael, 1966 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Adli, Mazda (author)
Alda, Martin (author)
Ardau, Raffaella (author)
Arias, Bárbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Karolinska Institutet
Badner, Judith A (author)
Barrett, Thomas B (author)
Bauer, Michael (author)
Baune, Bernhard T (author)
Bellivier, Frank (author)
Benabarre, Antonio (author)
Bengesser, Susanne (author)
Berrettini, Wade H (author)
Bhattacharjee, Abesh Kumar (author)
Biernacka, Joanna M (author)
Birner, Armin (author)
Bloss, Cinnamon S (author)
Brichant-Petitjean, Clara (author)
Bui, Elise T (author)
Byerley, William (author)
Cervantes, Pablo (author)
Chillotti, Caterina (author)
Karolinska Institutet
Cichon, Sven (author)
Colom, Francesc (author)
Coryell, William (author)
Craig, David W (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M (author)
Davis, Tony (author)
Dayer, Alexandre (author)
Degenhardt, Franziska (author)
Del Zompo, Maria (author)
DePaulo, J Raymond (author)
Edenberg, Howard J (author)
Étain, Bruno (author)
Falkai, Peter (author)
Foroud, Tatiana (author)
Forstner, Andreas J (author)
Frisén, Louise (author)
Karolinska Institutet
Frye, Mark A (author)
Fullerton, Janice M (author)
Gard, Sébastien (author)
Garnham, Julie S (author)
Gershon, Elliot S (author)
Goes, Fernando S (author)
Greenwood, Tiffany A (author)
Grigoroiu-Serbanescu, Maria (author)
Hauser, Joanna (author)
Heilbronner, Urs (author)
Heilmann-Heimbach, Stefanie (author)
Herms, Stefan (author)
Hipolito, Maria (author)
Hitturlingappa, Shashi (author)
Hoffmann, Per (author)
Hofmann, Andrea (author)
Jamain, Stephane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kelsoe, John R (author)
Kittel-Schneider, Sarah (author)
Kliwicki, Sebastian (author)
Koller, Daniel L (author)
König, Barbara (author)
Lackner, Nina (author)
Laje, Gonzalo (author)
Lang, Maren (author)
Lavebratt, Catharina (author)
Lawson, William B (author)
Leboyer, Marion (author)
Leckband, Susan G (author)
Liu, Chunyu (author)
Maaser, Anna (author)
Mahon, Pamela B (author)
Maier, Wolfgang (author)
Maj, Mario (author)
Karolinska Institutet
Manchia, Mirko (author)
Martinsson, Lina (author)
Karolinska Institutet
McCarthy, Michael J (author)
McElroy, Susan L (author)
McInnis, Melvin G (author)
McKinney, Rebecca (author)
Mitchell, Philip B (author)
Mitjans, Marina (author)
Mondimore, Francis M (author)
Monteleone, Palmiero (author)
Mühleisen, Thomas W (author)
Nievergelt, Caroline M (author)
Nöthen, Markus M (author)
Novák, Tomas (author)
Nurnberger, John I (author)
Nwulia, Evaristus A (author)
Ösby, Urban (author)
Pfennig, Andrea (author)
Potash, James B (author)
Propping, Peter (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rice, John (author)
Rietschel, Marcella (author)
Rouleau, Guy A (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Scheftner, William A (author)
Schofield, Peter R (author)
Schork, Nicholas J (author)
Schulze, Thomas G (author)
Schumacher, Johannes (author)
Schweizer, Barbara W (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D (author)
Simhandl, Christian (author)
Slaney, Claire M (author)
Smith, Erin N (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Streit, Fabian (author)
Strohmaier, Jana (author)
Szelinger, Szabolcs (author)
Tighe, Sarah K (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Volkert, Julia (author)
Witt, Stephanie H (author)
Wright, Adam (author)
Zandi, Peter P (author)
Zhang, Peng (author)
Zollner, Sebastian (author)
McMahon, Francis J (author)
show less...
 (creator_code:org_t)
2016-06-21
2016
English.
In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 25:15, s. 3383-94
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87 × 10(-9); odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53 × 10(-9); odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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art (subject category)

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By the author/editor
Hou, Liping
Bergen, Sarah E
Akula, Nirmala
Song, Jie
Hultman, Christi ...
Landén, Mikael, ...
show more...
Adli, Mazda
Alda, Martin
Ardau, Raffaella
Arias, Bárbara
Aubry, Jean-Mich ...
Backlund, Lena
Badner, Judith A
Barrett, Thomas ...
Bauer, Michael
Baune, Bernhard ...
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Berrettini, Wade ...
Bhattacharjee, A ...
Biernacka, Joann ...
Birner, Armin
Bloss, Cinnamon ...
Brichant-Petitje ...
Bui, Elise T
Byerley, William
Cervantes, Pablo
Chillotti, Cater ...
Cichon, Sven
Colom, Francesc
Coryell, William
Craig, David W
Cruceanu, Cristi ...
Czerski, Piotr M
Davis, Tony
Dayer, Alexandre
Degenhardt, Fran ...
Del Zompo, Maria
DePaulo, J Raymo ...
Edenberg, Howard ...
Étain, Bruno
Falkai, Peter
Foroud, Tatiana
Forstner, Andrea ...
Frisén, Louise
Frye, Mark A
Fullerton, Janic ...
Gard, Sébastien
Garnham, Julie S
Gershon, Elliot ...
Goes, Fernando S
Greenwood, Tiffa ...
Grigoroiu-Serban ...
Hauser, Joanna
Heilbronner, Urs
Heilmann-Heimbac ...
Herms, Stefan
Hipolito, Maria
Hitturlingappa, ...
Hoffmann, Per
Hofmann, Andrea
Jamain, Stephane
Jiménez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kelsoe, John R
Kittel-Schneider ...
Kliwicki, Sebast ...
Koller, Daniel L
König, Barbara
Lackner, Nina
Laje, Gonzalo
Lang, Maren
Lavebratt, Catha ...
Lawson, William ...
Leboyer, Marion
Leckband, Susan ...
Liu, Chunyu
Maaser, Anna
Mahon, Pamela B
Maier, Wolfgang
Maj, Mario
Manchia, Mirko
Martinsson, Lina
McCarthy, Michae ...
McElroy, Susan L
McInnis, Melvin ...
McKinney, Rebecc ...
Mitchell, Philip ...
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Mühleisen, Thoma ...
Nievergelt, Caro ...
Nöthen, Markus M
Novák, Tomas
Nurnberger, John ...
Nwulia, Evaristu ...
Ösby, Urban
Pfennig, Andrea
Potash, James B
Propping, Peter
Reif, Andreas
Reininghaus, Eva
Rice, John
Rietschel, Marce ...
Rouleau, Guy A
Rybakowski, Janu ...
Schalling, Marti ...
Scheftner, Willi ...
Schofield, Peter ...
Schork, Nicholas ...
Schulze, Thomas ...
Schumacher, Joha ...
Schweizer, Barba ...
Severino, Giovan ...
Shekhtman, Tatya ...
Shilling, Paul D
Simhandl, Christ ...
Slaney, Claire M
Smith, Erin N
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Streit, Fabian
Strohmaier, Jana
Szelinger, Szabo ...
Tighe, Sarah K
Tortorella, Alfo ...
Turecki, Gustavo
Vieta, Eduard
Volkert, Julia
Witt, Stephanie ...
Wright, Adam
Zandi, Peter P
Zhang, Peng
Zollner, Sebasti ...
McMahon, Francis ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Human molecular ...
By the university
University of Gothenburg
Karolinska Institutet

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