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Empirical assessmen...
Empirical assessment of biases in cerebrospinal fluid biomarkers of alzheimer’s disease : An umbrella review and re-analysis of data from meta-analyses
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- Jeong, D. Y. (författare)
- Yonsei University College of Medicine, Seoul, South Korea,Yonsei Univ, South Korea
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- Lee, J. (författare)
- Yonsei University, Wonju College of Medicine, Wonju, South Korea,Yonsei Univ, South Korea,Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France
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- Kim, J. Y. (författare)
- Yonsei University College of Medicine, Seoul, South Korea,Yonsei Univ, South Korea
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- Lee, K. H. (författare)
- Yonsei University College of Medicine, Seoul, South Korea,Yonsei Univ, South Korea
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- Li, H. (författare)
- University of Florida College of Medicine, Gainesville, FL, United States,Univ Florida, FL USA
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- Lee, J. Y. (författare)
- Yonsei University, Wonju College of Medicine, Wonju, South Korea
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- Jeong, G. H. (författare)
- Gyeongsang National University, Jinju, South Korea,Gyeongsang Natl Univ, South Korea
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- Yoon, S. (författare)
- Yonsei University College of Medicine, Seoul, South Korea,Yonsei Univ, South Korea
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- Park, E. L. (författare)
- Korea University College of Medicine, Seoul, South Korea,Korea Univ, South Korea
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- Hong, S. H. (författare)
- Yonsei University College of Medicine, Seoul, South Korea; Harvard T.H. Chan School of Public Health, Boston, MA, United States,Yonsei Univ, South Korea; Harvard TH Chan Sch Publ Hlth, MA USA
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- Kang, J. W. (författare)
- Chungnam National University College of Medicine, Daejon, South Korea,Chungnam Natl Univ, South Korea
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- Song, T. -J (författare)
- Seoul Hospital Ewha Womans University, College of Medicine, Seoul, South Korea,Ewha Womans Univ, South Korea,Univ Greenwich, England
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- Leyhe, T. (författare)
- Geriatric Psychiatry University, Department of Geriatric Medicine, FELIX PLATTER, Basel, Switzerland; Psychiatric University Hospital, Basel, Switzerland,Univ Basel, Switzerland; Psychiat Univ Hosp, Switzerland
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- Eisenhut, M. (författare)
- Luton and Dunstable University Hospital NHS Foundation Trust, Luton, United Kingdom,Luton & Dunstable Univ Hosp NHS Fdn Trust, England
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- Kronbichler, A. (författare)
- Medical University Innsbruck, Innsbruck, Austria,Med Univ Innsbruck, Austria
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- Smith, L. (författare)
- Anglia Ruskin University, Cambridge, United Kingdom,Anglia Ruskin Univ, England,Sejong Univ, South Korea
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- Solmi, M. (författare)
- University of Padua, Padua, Italy; King’s College London, London, United Kingdom,Univ Padua, Italy; Kings Coll London, England,Korea Univ, South Korea; Minist Hlth & Welf, South Korea
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- Stubbs, B. (författare)
- King’s College London, De Crespigny Park, London, United Kingdom; South London and Maudsley NHS Foundation Trust, Denmark Hill, London, United Kingdom; Anglia Ruskin University, Chelmsford, United Kingdom,Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Anglia Ruskin Univ, England
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- Koyanagi, A. (författare)
- Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain; ICREA, Barcelona, Spain,Univ Barcelona, Spain; ICREA, Spain
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- Jacob, L. (författare)
- University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
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- Stickley, Andrew (författare)
- Södertörns högskola,SCOHOST (Stockholm Centre for Health and Social Change),Sodertorn Univ, Sweden
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- Thompson, T. (författare)
- University of Greenwich, London, United Kingdom
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- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Oh, H. (författare)
- University of Southern California, Los Angeles, CA, United States,Univ Southern Calif, CA 90007 USA
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- Brunoni, A. R. (författare)
- University Hospital, LMU Munich, Munich, Germany; Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil; Hospital Universitario, Departamento de Clínica Médica, Faculdade de Medicina da USP, São Paulo, Brazil,Ludwig Maximilians Univ Munchen, Germany; Univ Sao Paulo, Brazil; Univ Sao Paulo, Brazil; Univ Sao Paulo, Brazil
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- Carvalho, A. F. (författare)
- Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada,Ctr Addict & Mental Hlth CAMH, Canada; Univ Toronto, Canada
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- Kim, M. S. (författare)
- Korea University, College of Medicine, Seoul, South Korea; Cheongsan Public Health Center, Ministry of Health and Welfare Wando, South Korea
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- Yon, D. K. (författare)
- Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea,Seoul Natl Univ, South Korea
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- Lee, S. W. (författare)
- Sejong University College of Software Convergence, Seoul, South Korea
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- Yang, J. M. (författare)
- University of Ulsan College of Medicine, Seoul, South Korea,Univ Ulsan, South Korea
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- Ghayda, R. A. (författare)
- University Hospitals and Case Western Reserve University, Cleveland, OH, United States,Univ Hosp, OH USA; Case Western Reserve Univ, OH 44106 USA
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- Shin, J. I. (författare)
- Yonsei University College of Medicine, Seoul, South Korea,Yonsei Univ, South Korea
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- Fusar-Poli, P. (författare)
- University of Padua, Padua, Italy; South London and Maudsley NHS Foundation Trust, London, United Kingdom; University of Pavia, Pavia, Italy,Univ Padua, Italy; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy
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(creator_code:org_t)
- Verduci Publisher, 2021
- 2021
- Engelska.
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Ingår i: European Review for Medical and Pharmacological Sciences. - : Verduci Publisher. - 1128-3602. ; 25:3, s. 1536-1547
- Relaterad länk:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Alzheimer’s disease (AD) is a leading cause of years lived with disability in older age, and several cerebrospinal fluid (CSF) markers have been proposed in individual meta-analyses to be associated with AD but field-wide evaluation and scrutiny of the literature is not available. MATERIALS AND METHODS: We performed an umbrella review for the reported associations between CSF biomarkers and AD. Data from available meta-analyses were reanalyzed using both random and fixed effects models. We also estimated between-study heterogeneity, small-study effects, excess significance, and prediction interval. RESULTS: A total of 38 meta-analyses on CSF markers from 11 eligible articles were identified and reanalyzed. In 14 (36%) of the meta-analyses, the summary estimate and the results of the largest study showed non-concordant results in terms of statistical significance. Large heterogeneity (I2≥75%) was observed in 73% and small-study effects under Egger’s test were shown in 28% of CSF biomarkers. CONCLUSIONS: Our results suggest that there is an excess of statistically significant results and significant biases in the literature of CSF biomarkers for AD. Therefore, the results of CSF biomarkers should be interpreted with caution.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer’s disease
- CSF biomarkers
- Excess significance
- Meta-analysis
- Umbrella review
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jeong, D. Y.
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Lee, J.
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Kim, J. Y.
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Lee, K. H.
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Li, H.
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Lee, J. Y.
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visa fler...
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Jeong, G. H.
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Yoon, S.
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Park, E. L.
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Hong, S. H.
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Kang, J. W.
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Song, T. -J
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Leyhe, T.
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Eisenhut, M.
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Kronbichler, A.
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Smith, L.
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Solmi, M.
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Stubbs, B.
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Koyanagi, A.
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Jacob, L.
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Stickley, Andrew
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Thompson, T.
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Dragioti, Elena
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Oh, H.
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Brunoni, A. R.
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Carvalho, A. F.
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Kim, M. S.
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Yon, D. K.
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Lee, S. W.
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Yang, J. M.
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Ghayda, R. A.
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Shin, J. I.
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Fusar-Poli, P.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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European Review ...
- Av lärosätet
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Södertörns högskola
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Linköpings universitet