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A clinical grade co...
A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells : implications for immunotherapy
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- Lee, Andrew W (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
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- Truong, Tuan (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY , USA
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- Bickham, Kara (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
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- Fonteneau, Jean-Francois (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
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- Larsson, Marie, 1966- (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY , USA
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- Da Silva, Ida (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY , USA
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- Somersan, Selin (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
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- Thomas, Elaine K (författare)
- Immunex Corporation, Seattle, WA, USA
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- Bhardwaj, Nina (författare)
- Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY, USA
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(creator_code:org_t)
- Elsevier BV, 2002
- 2002
- Engelska.
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Ingår i: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 20:Suppl. 4, s. A8-A22
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dendritic cells (DCs) can induce tumor- or pathogen-specific T cell responses in humans. We comprehensively compared the clinically available DC maturation stimuli for their ability to promote uniformly mature DCs that elicit higher levels of T cell responses. We compared the standard maturation stimulus, autologous monocyte-conditioned medium (MCM), with a synthetic double stranded RNA (poly I:C), soluble CD40 ligand trimer, and a defined cocktail of cytokines (TNF-α, IL-1β, IL-6) and PGE2 to promote mature phenotype and function in human monocyte-derived DCs. The cocktail was the most efficient despite the lack of induction of IL-12p70. While these results support the use of the MCM-mimic cocktail in clinical DC immunotherapy trials, the roles of it’s individual constituents remain to be completely defined.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- Dendritic cells
- T cell activation
- Vaccination
- Immunotherapy
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- ref (ämneskategori)
- art (ämneskategori)
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Lee, Andrew W
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Truong, Tuan
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Bickham, Kara
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Fonteneau, Jean- ...
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Larsson, Marie, ...
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Da Silva, Ida
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visa fler...
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Somersan, Selin
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Thomas, Elaine K
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Bhardwaj, Nina
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visa färre...
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