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SERT and NET polymo...
SERT and NET polymorphisms, temperament and antidepressant response
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Andre, Kadri (författare)
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Kampman, Olli (författare)
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Illi, Ari (författare)
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Viikki, Merja (författare)
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Setala-Soikkeli, Eija (författare)
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Mononen, Nina (författare)
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Lehtimaki, Terho (författare)
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- Haraldsson, Susann (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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Koivisto, Pasi A. (författare)
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Leinonen, Esa (författare)
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(creator_code:org_t)
- 2015-03-05
- 2015
- Engelska.
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Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 69:7, s. 531-538
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. Aims: We investigated the separate effects and possible interactions between NET T-182C (rs2242446) and SERT 5-HTTLPR (rs4795541) polymorphisms on selective serotonin reuptake inhibitors (SSRI) treatment response and temperamental traits assessed by the Temperament and Character Inventory (TCI) in a clinical sample of subjects with major depressive disorder (MDD). Methods: Our sample of 97 patients with major depression completed the 107-item TCI temperament questionnaire (version IX) at the initial assessment of the study and after 6 weeks of follow-up. All subjects received selective SSRI medications. Temperament dimension scores at baseline (1) and endpoint (2) during antidepressant treatment were analyzed between NET and SERT genotypes. Results: SS-genotype of 5-HTTLPR was associated with higher baseline Persistence scores than SL- or LL-genotype. A corresponding but weaker association was found at endpoint. No differences were found between 5-HTTLPR genotypes and other temperament dimensions and 5-HTTLPR genotypes had no effect on treatment response. Conclusions: Our results suggest that the SS-genotype of 5-HTTLPR is associated with Persistence scores in patients with MDD. Higher Persistence could be viewed as a negative trait when recovering from stress and its association with short and "weaker" S-allele may be related to less efficient serotonin neurotransmission, possibly resulting in less effective coping strategies on a behavioral level.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Antidepressant treatment
- Depression
- NET
- SERT
- Temperament
Publikations- och innehållstyp
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- art (ämneskategori)
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Andre, Kadri
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Kampman, Olli
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Illi, Ari
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Viikki, Merja
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Setala-Soikkeli, ...
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Mononen, Nina
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visa fler...
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Lehtimaki, Terho
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Haraldsson, Susa ...
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Koivisto, Pasi A ...
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Leinonen, Esa
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visa färre...
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Umeå universitet