FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

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FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals

Qi, Qibin (author): Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USA

Kilpeläinen, Tuomas O (author)

Kristiansson, Kati (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups

Tanaka, Toshiko (author)

Smith, Caren E (author)

Sluijs, Ivonne (author)

Sonestedt, Emily (author): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Chu, Audrey Y (author)

Renström, Frida (author): Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups

Lin, Xiaochen (author)

Angquist, Lars H (author)

Huang, Jinyan (author)

Liu, Zhonghua (author)

Li, Yanping (author)

Asif Ali, Muhammad (author)

Xu, Min (author)

Ahluwalia, Tarunveer Singh (author)

Boer, Jolanda M A (author)

Chen, Peng (author)

Daimon, Makoto (author)

Eriksson, Johan (author)

Perola, Markus (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups

Friedlander, Yechiel (author)

Gao, Yu-Tang (author)

Heppe, Denise H M (author)

Holloway, John W (author)

Houston, Denise K (author)

Kanoni, Stavroula (author)

Kim, Yu-Mi (author)

Laaksonen, Maarit A (author)

Jääskeläinen, Tiina (author)

Lee, Nanette R (author)

Lehtimäki, Terho (author)

Lemaitre, Rozenn N (author)

Lu, Wei (author)

Luben, Robert N (author)

Manichaikul, Ani (author)

Männistö, Satu (author)

Marques-Vidal, Pedro (author)

Monda, Keri L (author)

Ngwa, Julius S (author)

Perusse, Louis (author)

van Rooij, Frank J A (author)

Xiang, Yong-Bing (author)

Wen, Wanqing (author)

Wojczynski, Mary K (author)

Zhu, Jingwen (author)

Borecki, Ingrid B (author)

Bouchard, Claude (author)

Cai, Qiuyin (author)

Cooper, Cyrus (author)

Dedoussis, George V (author)

Deloukas, Panos (author)

Ferrucci, Luigi (author)

Forouhi, Nita G (author)

Hansen, Torben (author)

Christiansen, Lene (author)

Hofman, Albert (author)

Johansson, Ingegerd (author): Umeå universitet,Institutionen för odontologi

Jørgensen, Torben (author)

Karasawa, Shigeru (author)

Khaw, Kay-Tee (author)

Kim, Mi-Kyung (author)

Kristiansson, Kati (author)

Li, Huaixing (author)

Lin, Xu (author)

Liu, Yongmei (author)

Lohman, Kurt K (author)

Long, Jirong (author)

Mikkilä, Vera (author)

Mozaffarian, Dariush (author)

North, Kari (author)

Pedersen, Oluf (author)

Raitakari, Olli (author)

Rissanen, Harri (author)

Tuomilehto, Jaakko (author)

van der Schouw, Yvonne T (author)

Uitterlinden, André G (author)

Carola Zillikens, M (author)

Franco, Oscar H (author)

Shyong Tai, E (author)

Ou Shu, Xiao (author)

Siscovick, David S (author)

Toft, Ulla (author)

Monique Verschuren, W M (author)

Vollenweider, Peter (author)

Wareham, Nicholas J (author)

Witteman, Jacqueline C M (author)

Zheng, Wei (author)

Ridker, Paul M (author)

Kang, Jae H (author)

Liang, Liming (author)

Jensen, Majken K (author)

Curhan, Gary C (author)

Pasquale, Louis R (author)

Hunter, David J (author)

Mohlke, Karen L (author)

Uusitupa, Matti (author)

Adrienne Cupples, L (author)

Rankinen, Tuomo (author)

Orho-Melander, Marju (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease

Wang, Tao (author)

Chasman, Daniel I (author)

Franks, Paul (author): Lund University,Lunds universitet,Umeå universitet,Medicin,Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology

Sørensen, Thorkild I A (author)

Hu, Frank B (author)

Loos, Ruth J F (author)

Nettleton, Jennifer A (author)

Qi, Lu (author)

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(creator_code:org_t)

2014-08-07
2014
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:25, s. 6961-6972

Related links:: https://academic.oup...; show more...; http://www.ncbi.nlm....; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.

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By the author/editor: Qi, Qibin; Kilpeläinen, Tuo ...; Kristiansson, Ka ...; Tanaka, Toshiko; Smith, Caren E; Sluijs, Ivonne; show more...; Sonestedt, Emily; Chu, Audrey Y; Renström, Frida; Lin, Xiaochen; Angquist, Lars H; Huang, Jinyan; Liu, Zhonghua; Li, Yanping; Asif Ali, Muhamm ...; Xu, Min; Ahluwalia, Tarun ...; Boer, Jolanda M ...; Chen, Peng; Daimon, Makoto; Eriksson, Johan; Perola, Markus; Friedlander, Yec ...; Gao, Yu-Tang; Heppe, Denise H ...; Holloway, John W; Houston, Denise ...; Kanoni, Stavroul ...; Kim, Yu-Mi; Laaksonen, Maari ...; Jääskeläinen, Ti ...; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn ...; Lu, Wei; Luben, Robert N; Manichaikul, Ani; Männistö, Satu; Marques-Vidal, P ...; Monda, Keri L; Ngwa, Julius S; Perusse, Louis; van Rooij, Frank ...; Xiang, Yong-Bing; Wen, Wanqing; Wojczynski, Mary ...; Zhu, Jingwen; Borecki, Ingrid ...; Bouchard, Claude; Cai, Qiuyin; Cooper, Cyrus; Dedoussis, Georg ...; Deloukas, Panos; Ferrucci, Luigi; Forouhi, Nita G; Hansen, Torben; Christiansen, Le ...; Hofman, Albert; Johansson, Ingeg ...; Jørgensen, Torbe ...; Karasawa, Shiger ...; Khaw, Kay-Tee; Kim, Mi-Kyung; Li, Huaixing; Lin, Xu; Liu, Yongmei; Lohman, Kurt K; Long, Jirong; Mikkilä, Vera; Mozaffarian, Dar ...; North, Kari; Pedersen, Oluf; Raitakari, Olli; Rissanen, Harri; Tuomilehto, Jaak ...; van der Schouw, ...; Uitterlinden, An ...; Carola Zillikens ...; Franco, Oscar H; Shyong Tai, E; Ou Shu, Xiao; Siscovick, David ...; Toft, Ulla; Monique Verschur ...; Vollenweider, Pe ...; Wareham, Nichola ...; Witteman, Jacque ...; Zheng, Wei; Ridker, Paul M; Kang, Jae H; Liang, Liming; Jensen, Majken K; Curhan, Gary C; Pasquale, Louis ...; Hunter, David J; Mohlke, Karen L; Uusitupa, Matti; Adrienne Cupples ...; Rankinen, Tuomo; Orho-Melander, M ...; Wang, Tao; Chasman, Daniel ...; Franks, Paul; Sørensen, Thorki ...; Hu, Frank B; Loos, Ruth J F; Nettleton, Jenni ...; Qi, Lu; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Articles in the publication: Human Molecular ...

By the university: Umeå University; Lund University

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FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals

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