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C3 and C4 are stron...
C3 and C4 are strongly related to adipose tissue variables and cardiovascular risk factors
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- Nilsson, Bo (författare)
- Uppsala universitet,Klinisk immunologi,Uppsala University
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- Hamad, Osama (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala University
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Kullberg, Joel (författare)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Johansson, Lars (författare)
- Uppsala universitet,Enheten för radiologi,Uppsala University
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- Lindhagen, Lars (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University
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- Hänni, Arvo (författare)
- Uppsala universitet,Geriatrik,Uppsala University
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- Nilsson Ekdahl, Kristina (författare)
- Uppsala universitet,Klinisk immunologi,Uppsala University,Linnaeus Ctr Biomat Chem, BMC
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- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University
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(creator_code:org_t)
- 2014-05-20
- 2014
- Engelska.
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Ingår i: European Journal of Clinical Investigation. - : John Wiley & Sons. - 0014-2972 .- 1365-2362. ; 44:6, s. 587-596
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly individuals. Methods In this study, C3 and C4 and the activation fragment C3a-desArg were analysed in 1016 subjects aged 70, in which blood pressure, lipid variables and fasting blood glucose were assessed. Results C3 levels were related to all the investigated classical cardiovascular risk factors and the metabolic syndrome (BMI, waist circumference, fat distribution, blood pressure, blood glucose levels, TG) except total cholesterol and LDL cholesterol in a highly significant fashion (Spearman up to 0,5; P<0.0001). C4 and C3a-desArg were associated in the same fashion but less significantly, while the ratios C4/C3 or C3a-desArg/C3 were not, indicating thatthe association was not directly related to complement activation. The levels C3 and to a lesser degree C4 and C3a-desArg were associated particularly with CRP, but also with E-selectin and ICAM-1. In addition, C3 and C4 levels were shown to decline significantly in 15 female subjects enrolled in a weight-reduction programme over 4 months. Conclusion A strong relation between C3, C4 and C3a-desArg levels, adipose tissue and risk factors of CVD was established. The data support that theadipose tissue produces complement components and generates initiators of inflammation, such as C3a and C5a, able to trigger a cyto/chemokine response, in proportion to the amount of adipose tissue. This corroborates the concept that complement contributes to the low-grade inflammation associated with obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Biomedical Sciences
- Biomedicinsk vetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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