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Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

Borena, Wegene (author)
Strohmaier, Susanne (author)
Lukanova, Annekatrin (author)
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Bjorge, Tone (author)
Lindkvist, Bjorn (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Edlinger, Michael (author)
Stocks, Tanja (author)
Umeå universitet,Umeå University,Urologi och andrologi
Nagel, Gabriele (author)
Manjer, Jonas (author)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
Engeland, Anders (author)
Selmer, Randi (author)
Häggström, Christel (author)
Umeå universitet,Urologi och andrologi
Tretli, Steinar (author)
Concin, Hans (author)
Jonsson, Håkan (author)
Umeå universitet,Onkologi
Stattin, Pär (author)
Umeå universitet,Urologi och andrologi
Ulmer, Hanno (author)
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 (creator_code:org_t)
2011-09-08
2012
English.
In: International Journal of Cancer. - Malden, MA : Wiley. - 0020-7136 .- 1097-0215. ; 131:1, s. 193-200
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic risk factors and primary liver cancer (PLC) has not been investigated. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria and Sweden with data on 578,700 subjects. We used Cox proportional hazard models to calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure and plasma levels of glucose, cholesterol and triglycerides as continuous standardized variables (z-score with mean = 0 and standard deviation (SD) = 1) and their standardized sum of metabolic syndrome (MetS) z-score. RRs were corrected for random error in measurements. During an average follow-up of 12.0 years (SD = 7.8), 266 PLCs were diagnosed among cohort members. RR of liver cancer per unit increment of z-score adjusted for age, smoking status and BMI and stratified by birth year, sex and sub-cohorts, was for BMI 1.39 (95% confidence interval (CI) 1.241.58), mid blood pressure 2.08 (0.954.73), blood glucose 2.13 (1.552.94) cholesterol 0.62 (0.510.76) and serum triglycerides 0.85 (0.651.10). The RR per one unit increment of the MetS z-score was 1.35 (1.121.61). BMI, glucose and a composite MetS score were positively and cholesterol negatively associated with risk of liver cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

cohort study
epidemiology
hepatocellular carcinoma
intrahepatic
cholangiocarcinoma
metabolic syndrome
cohort study

Publication and Content Type

art (subject category)
ref (subject category)

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