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Metabolic syndrome ...
Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can)
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- Häggström, Christel (författare)
- Umeå universitet,Urologi och andrologi
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- Stocks, Tanja (författare)
- Umeå universitet,Umeå University,Urologi och andrologi
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- Rapp, Kilian (författare)
- Univ Ulm, Inst Epidemiol, Ulm, Germany
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- Bjorge, Tone (författare)
- Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
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- Lindkvist, Bjorn (författare)
- Univ Gothenburg, Sahlgrenska Acad, Dept Med, Gothenburg, Sweden
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- Concin, Hans (författare)
- Agcy Prevent & Social Med, Bregenz, Austria
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- Engeland, Anders (författare)
- Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Malmö Univ Hosp, Dept Surg, Malmö, Sweden
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- Ulmer, Hanno (författare)
- Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria
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- Selmer, Randi (författare)
- Norwegian Inst Publ Hlth, Oslo, Norway
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- Tretli, Steinar (författare)
- Canc Registry Norway, Inst Populat Based Canc Res, Oslo, Norway
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Jonsson, Håkan (författare)
- Umeå universitet,Onkologi
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- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
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(creator_code:org_t)
- 2010-06-21
- 2011
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 128:8, s. 1890-1898
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportional hazard models to calculate relative risks (RRs) of bladder cancer by exposures divided into quintiles, in categories according to the World Health Organisation (WHO) and as a continuous standardized variable (z-score with mean = 0 and standard deviation = 1) for each separate component and its standardized sum, a composite MetS score. RRs were corrected for random error in measurements. During a mean follow-up of 11.7 years (SD = 7.6), 1,587 men and 327 women were diagnosed with bladder cancer. Significant associations with risk were found among men per one unit increment of z-score for blood pressure, RR 5 1.13 (95% CI 1.03-1.25), and the composite MetS score, RR = 1.10 (95% CI 1.01-1.18). Among women, glucose was nonsignificantly associated with risk, RR = 1.41 (95% CI 0.97-2.06). No statistically significant interactions were found between the components in the MetS in relation to bladder cancer risk. Hypertension and a composite MetS score were significantly but modestly associated with an increased risk of bladder cancer among men and elevated glucose was associated with a nonsignificant increase in risk among women. Epidemiology
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- epidemiology
- bladder cancer
- metabolic syndrome
- cohort study
- epidemiology;bladder cancer;metabolic syndrome;cohort study
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
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Häggström, Chris ...
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Stocks, Tanja
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Rapp, Kilian
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Bjorge, Tone
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Lindkvist, Bjorn
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Concin, Hans
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visa fler...
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Engeland, Anders
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Manjer, Jonas
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Ulmer, Hanno
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Selmer, Randi
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Tretli, Steinar
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Hallmans, Göran
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Jonsson, Håkan
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Stattin, Pär
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