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Sökning: onr:"swepub:oai:DiVA.org:umu-221666" > BMI and breast canc...

BMI and breast cancer risk around age at menopause

Von Holle, Ann (författare)
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
Adami, Hans-Olov (författare)
Clinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinksa Institutet, Stockholm, Sweden
Baglietto, Laura (författare)
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Berrington, Amy (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
Bertrand, Kimberly A. (författare)
Slone Epidemiology Center, Boston University, MA, Boston, United States
Blot, William (författare)
Vanderbilt University Medical Center, TN, Nashville, United States
Chen, Yu (författare)
Division of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, NY, New York, United States
DeHart, Jessica Clague (författare)
School of Community and Global Health, Claremont Graduate University, CA, Claremont, United States
Dossus, Laure (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Eliassen, A. Heather (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Fournier, Agnes (författare)
Centre for Research in Epidemiology and Statistics, Paris, France
Garcia-Closas, Montse (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
Giles, Graham (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Guevara, Marcela (författare)
Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain
Hankinson, Susan E. (författare)
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States
Heath, Alicia (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Jones, Michael E. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
Joshu, Corinne E. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
Kirsh, Victoria A. (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Kitahara, Cari M. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Koh, Woon-Puay (författare)
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore
Linet, Martha S. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Park, Hannah Lui (författare)
Department of Pathology and Laboratory Medicine, Department of Epidemiology, UC Irvine School of Medicine, CA, Irvine, United States
Masala, Giovanna (författare)
Institute for the Study and Prevention of Cancer, Florence, Italy
Mellemkjaer, Lene (författare)
Diet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark
Milne, Roger L. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
O'Brien, Katie M. (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
Palmer, Julie R. (författare)
Slone Epidemiology Center, Boston University, MA, Boston, United States
Riboli, Elio (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Rohan, Thomas E. (författare)
Albert Einstein College of Medicine, NY, Bronx, United States
Shrubsole, Martha J. (författare)
Vanderbilt University Medical Center, TN, Nashville, United States
Sund, Malin (författare)
Umeå universitet,Kirurgi
Tamimi, Rulla (författare)
Department of Population Health Sciences, Weill Cornell Medical College, NY, United States
Tin Tin, Sandar (författare)
Cancer Epidemiology Unit, Oxford Population Health, University of Oxford, United Kingdom
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Vermeulen, Roel CH (författare)
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization, Lyon, France
Willett, Walter C. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Yuan, Jian-Min (författare)
Division of Cancer Control and Population Science, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States; Department of Epidemiology, University of Pittsburgh, PA, Pittsburgh, United States
Zeleniuch-Jacquotte, Anne (författare)
Department of Population Health, NYU Grossman School of Medicine, NY, United States
Nichols, Hazel B. (författare)
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, NC, Chapel Hill, United States
Sandler, Dale P. (författare)
Epidemiology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
Swerdlow, Anthony J. (författare)
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom
Schoemaker, Minouk J. (författare)
Real World Solutions, IQVIA, Netherlands
Weinberg, Clarice R. (författare)
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NC, Research Triangle Park, United States
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Cancer Epidemiology. - : Elsevier. - 1877-7821 .- 1877-783X. ; 89
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: A high body mass index (BMI, kg/m2) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.Methods: We examined the association between BMI and breast cancer risk in the Premenopausal Breast Cancer Collaborative Group, from age 45 up to breast cancer diagnosis, loss to follow-up, death, or age 55, whichever came first. Analyses included 609,880 women in 16 prospective studies, including 9956 who developed breast cancer before age 55. We fitted three BMI hazard ratio (HR) models over age-time: constant, linear, or nonlinear (via splines), applying piecewise exponential additive mixed models, with age as the primary time scale. We divided person-time into four strata: premenopause; postmenopause due to natural menopause; postmenopause because of interventional loss of ovarian function (bilateral oophorectomy (BO) or chemotherapy); postmenopause due to hysterectomy without BO. Sensitivity analyses included stratifying by BMI in young adulthood, or excluding women using menopausal hormone therapy.Results: The constant BMI HR model provided the best fit for all four menopausal status groups. Under this model, the estimated association between a five-unit increment in BMI and breast cancer risk was HR=0.87 (95% CI: 0.85, 0.89) before menopause, HR=1.00 (95% CI: 0.96, 1.04) after natural menopause, HR=0.99 (95% CI: 0.93, 1.05) after interventional loss of ovarian function, and HR=0.88 (95% CI: 0.76, 1.02) after hysterectomy without BO.Conclusion: The BMI breast cancer HRs remained less than or near one during the 45–55 year age range indicating that the transition to a positive association between BMI and risk occurs after age 55.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Body mass index
Breast neoplasms
Middle aged
Postmenopause
Premenopause

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art (ämneskategori)

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