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A variant near the ...
A variant near the interleukin-6 gene is associated with fat mass in Caucasian men
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- Andersson, Niklas, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Strandberg, Louise, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Adamovic, Svetlana, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,University of Gothenburg
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skånes universitetssjukhus (SUS),Skåne University Hospital
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- Ljunggren, Östen (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Disease
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Lane, N. E. (author)
- University of California
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- Zmuda, J. M. (author)
- University of Pittsburgh
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- Nielsen, C. (author)
- Oregon Health and Science University
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- Orwoll, E. (author)
- Oregon Health and Science University
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg
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- Grahnemo, Louise (author)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2010-02-16
- 2010
- English.
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In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 34:6, s. 1011-9
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Abstract
Subject headings
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- CONTEXT: Regulation of fat mass appears to be associated with immune functions. Studies of knockout mice show that endogenous interleukin (IL)-6 can suppress mature-onset obesity. OBJECTIVE: To systematically investigate associations of single nucleotide polymorphisms (SNPs) near the IL-6 (IL6) and IL-6 receptor (IL6R) genes with body fat mass, in support for our hypothesis that variants of these genes can be associated with obesity. DESIGN AND STUDY SUBJECTS: The Gothenburg Osteoporosis and Obesity Determinants (GOOD) study is a population-based cross-sectional study of 18- to 20-year-old men (n=1049), from the Gothenburg area (Sweden). Major findings were confirmed in two additional cohorts consisting of elderly men from the Osteoporotic Fractures in Men (MrOS) Sweden (n=2851) and MrOS US (n=5611) multicenter population-based studies. MAIN OUTCOME: The genotype distributions and their association with fat mass in different compartments, measured with dual-energy X-ray absorptiometry. RESULTS: Out of 18 evaluated tag SNPs near the IL6 and IL6R genes, a recently identified SNP rs10242595 G/A (minor allele frequency=29%) 3' of the IL6 gene was negatively associated with the primary outcome total body fat mass (effect size -0.11 standard deviation (s.d.) units per A allele, P=0.02). This negative association with fat mass was also confirmed in the combined MrOS Sweden and MrOS US cohorts (effect size -0.05 s.d. units per A allele, P=0.002). When all three cohorts were combined (n=8927, Caucasian subjects), rs10242595(*)A showed a negative association with total body fat mass (effect size -0.05 s.d. units per A allele, P<0.0002). Furthermore, the rs10242595(*)A was associated with low body mass index (effect size -0.03, P<0.001) and smaller regional fat masses. None of the other SNPs investigated in the GOOD study were reproducibly associated with body fat. CONCLUSIONS: The IL6 gene polymorphism rs10242595(*)A is associated with decreased fat mass in three combined cohorts of 8927 Caucasian men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Absorptiometry
- Photon
- Adiposity/*genetics
- Adolescent
- Aged
- Body Mass Index
- Cross-Sectional Studies
- European Continental Ancestry Group/genetics
- Gene Frequency/genetics/physiology
- Genetic Variation/genetics
- Genotype
- Humans
- Interleukin-6/*genetics/physiology
- Male
- Obesity/*genetics/physiopathology
- Polymorphism
- Single Nucleotide/*genetics
- Receptors
- Interleukin-6/*genetics/physiology
- Sweden
- Young Adult
- rs10242595
- SNP
- IL6
- IL6R
- Adiposity/*genetics
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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Andersson, Nikla ...
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Strandberg, Loui ...
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Nilsson, Staffan ...
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Adamovic, Svetla ...
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Karlsson, Magnus
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Ljunggren, Östen
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show more...
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Mellström, Dan, ...
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Lane, N. E.
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Zmuda, J. M.
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Nielsen, C.
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Orwoll, E.
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Lorentzon, Matti ...
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Ohlsson, Claes, ...
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Jansson, John-Ol ...
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Grahnemo, Louise
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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University of Gothenburg
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Lund University
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Chalmers University of Technology
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Uppsala University