Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

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Biomarker-based prognosis for people with mild cognitive impairment (ABIDE) : a modelling study

van Maurik, Ingrid S. (författare): Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

Vos, Stephanie J. (författare): Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht, Netherlands

Bos, Isabelle (författare): Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands; Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht, Netherlands

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Bouwman, Femke H. (författare): Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands,Eisai Inc.,Paris-Sorbonne University,Pitié-Salpêtrière University Hospital

Teunissen, Charlotte E. (författare): Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

Scheltens, Philip (författare): Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

Barkhof, Frederik (författare): Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam,University College London

Frolich, Lutz (författare): Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, Medical Faculty Mannheim University of Heidelberg, Germany

Kornhuber, Johannes (författare): Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany

Wiltfang, Jens (författare): Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany; German Center for Neurodegenerative Diseases, Göttingen, Germany; iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal,German Center for Neurodegenerative Diseases (DZNE), Bonn

Maier, Wolfgang (författare): Department of Neurodegenerative Diseases and Gerotopsychiatry, University of Bonn, German Center for Neurodegenerative Diseases, Bonn, Germany

Peters, Oliver (författare): Department of Psychiatry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; German Center for Neurodegenerative Diseases, Berlin, Germany,German Center for Neurodegenerative Diseases (DZNE), Bonn,Charité - University Medicine Berlin

Rüther, Eckart (författare): Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany

Nobili, Flavio (författare): Clinical Neurology, Department of Neurosciences, University of Genoa, Genoa, Italy; Neurology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

Frisoni, Giovanni B. (författare): Memory Clinic, University Hospital and University of Geneva, Geneva, Switzerland

Spiru, Luiza (författare): Geriatrics, Gerontology and Old Age Psychiatry Clinical Department, Carol Davila University of Medicine and Pharmacy-"Elias" Emergency Clinical Hospital, Bucharest, Romania; Memory Clinic and Longevity Medicine, Ana Aslan International Foundation, Romania

Freund-Levi, Yvonne, 1956- (författare): Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, UK

Wallin, Asa K. (författare): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups

Hampel, Harald (författare): Alzheimer Precision Medicine, GRC 21, Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France; Eisai, Neurology Business Group, Woodcliff Lake, NJ, USA

Soininen, Hilkka (författare): Institute of Clinical Medicine, Neurology, University of Eastern Finland and Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland

Tsolaki, Magda (författare): 1st Department of Neurology, Aristotle University of Thessaloniki, Memory and Dementia Center, "AHEPA" General Hospital, Thessaloniki, Greece

Verhey, Frans (författare): Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht, Netherlands

Kłoszewska, Iwona (författare): Department of Geriatric Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland

Mecocci, Patrizia (författare): Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy

Vellas, Bruno (författare): UMR INSERM 1027, CHU Toulouse, Toulouse, France,Toulouse University Hospital

Lovestone, Simon (författare): Department of Psychiatry, University of Oxford, Oxford, UK

Galluzzi, Samantha (författare): Lab Alzheimer's Neuroimaging and Epidemiology, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy,Centro San Giovanni di Dio Fatebenefratelli

Herukka, Sanna-Kaisa (författare): Institute of Clinical Medicine, Neurology, University of Eastern Finland and Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland

Santana, Isabel (författare): Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

Baldeiras, Ines (författare): Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal

de Mendonça, Alexandre (författare): Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Silva, Dina (författare): Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Centre for Biomedical Research, Universidade do Algarve, Faro, Portugal

Chetelat, Gael (författare): Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France

Egret, Stephanie (författare): Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France

Palmqvist, Sebastian (författare): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital

Hansson, Oskar (författare): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital

Visser, Pieter Jelle (författare): Karolinska Institutet

Berkhof, Johannes (författare): Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

van der Flier, Wiesje M. (författare): Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands; Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

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(creator_code:org_t)

The Lancet Publishing Group, 2019
2019
Engelska.
Ingår i: Lancet Neurology. - : The Lancet Publishing Group. - 1474-4422 .- 1474-4465. ; 18:11, s. 1034-1044

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; http://kipublication...; visa färre...

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BACKGROUND: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia.METHODS: In this modelling study, we included people with mild cognitive impairment (MCI) from single-centre and multicentre cohorts in Europe and North America: the European Medical Information Framework for Alzheimer's Disease (EMIF-AD; n=883), Alzheimer's Disease Neuroimaging Initiative (ADNI; n=829), Amsterdam Dementia Cohort (ADC; n=666), and the Swedish BioFINDER study (n=233). Inclusion criteria were a baseline diagnosis of MCI, at least 6 months of follow-up, and availability of a baseline Mini-Mental State Examination (MMSE) and MRI or CSF biomarker assessment. The primary endpoint was clinical progression to any type of dementia. We evaluated performance of previously developed risk prediction models-a demographics model, a hippocampal volume model, and a CSF biomarkers model-by evaluating them across cohorts, incorporating different biomarker measurement methods, and determining prognostic performance with Harrell's C statistic. We then updated the models by re-estimating parameters with and without centre-specific effects and evaluated model calibration by comparing observed and expected survival. Finally, we constructed a model combining markers for amyloid deposition, tauopathy, and neurodegeneration (ATN), in accordance with the National Institute on Aging and Alzheimer's Association research framework.FINDINGS: We included all 2611 individuals with MCI in the four cohorts, 1007 (39%) of whom progressed to dementia. The validated demographics model (Harrell's C 0·62, 95% CI 0·59-0·65), validated hippocampal volume model (0·67, 0·62-0·72), and updated CSF biomarkers model (0·72, 0·68-0·74) had adequate prognostic performance across cohorts and were well calibrated. The newly constructed ATN model had the highest performance (0·74, 0·71-0·76).INTERPRETATION: We generated risk models that are robust across cohorts, which adds to their potential clinical applicability. The models could aid clinicians in the interpretation of CSF biomarker and hippocampal volume results in individuals with MCI, and help research and clinical settings to prepare for a future of precision medicine in Alzheimer's disease. Future research should focus on the clinical utility of the models, particularly if their use affects participants' understanding, emotional wellbeing, and behaviour.

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Artiklar i publikationen: Lancet Neurology

Av lärosätet: Örebro universitet; Lunds universitet; Karolinska Institutet

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Biomarker-based prognosis for people with mild cognitive impairment (ABIDE) : a modelling study

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