Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

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Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

Vos, Stephanie J. B. (författare): Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht, The Netherlands

Verhey, Frans (författare): Department of Psychiatry and Neuropsychology, Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht, The Netherlands

Frölich, Lutz (författare): Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany

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Kornhuber, Johannes (författare): Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen, Erlangen, Germany

Wiltfang, Jens (författare): Department of Psychiatry and Psychotherapy, University Medical Centre (UMG), Georg-August-University, Göttingen, Germany

Maier, Wolfgang (författare): Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany

Peters, Oliver (författare): Department of Psychiatry and Psychotherapy, Charité Berlin, Berlin, Germany

Rüther, Eckart (författare): Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany

Nobili, Flavio (författare): Clinical Neurophysiology Service, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy

Morbelli, Silvia (författare): Nuclear Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy

Frisoni, Giovanni B. (författare): IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy; University Hospitals and University of Geneva, Geneva, Switzerland

Drzezga, Alexander (författare): Department of Nuclear Medicine, University of Cologne, Cologne, Germany

Didic, Mira (författare): Service de Neurologie et Neuropsychologie, Pôle de neurosciences cliniques, AP-HM Timone, Aix Marseille Université, Marseille, France

van Berckel, Bart N. M. (författare): Department of Nuclear Medicine and PET Research, VU University Medical CentRE, Amsterdam, The Netherlands

Simmons, Andrew (författare): Karolinska Institutet

Soininen, Hilkka (författare): Institute of Clinical Medicine, Neurology, University of Eastern Finland and Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland

Kłoszewska, Iwona (författare): Medical University of Lodz, Lodz, Poland

Mecocci, Patrizia (författare): Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy

Tsolaki, Magda (författare): Aristotle University of Thessaloniki, Memory and Dementia Center, 3rd Department of Neurology, “G Papanicolaou” General Hospital, Thessaloniki, Greece

Vellas, Bruno (författare): UMR INSERM 1027, CHU Toulouse, Toulouse, France

Lovestone, Simon (författare): Department of Psychiatry, University of Oxford, Oxford, UK

Muscio, Cristina (författare): IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Fondazione Europea Ricerca Biomedica (FERB), Centro di Eccellenza Alzheimer, Ospedale Briolini, Gazzaniga, Bergamo, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

Herukka, Sanna-Kaisa (författare): Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland

Salmon, Eric (författare): Memory Clinic, Department of Neurology, CHU Liège, Belgium; Cyclotron Research Centre, University of Liège, Liège, Belgium

Bastin, Christine (författare): Cyclotron Research Centre, University of Liège, Liège, Belgium

Wallin, Anders, 1950 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Nordlund, Arto, 1962 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

de Mendonça, Alexandre (författare): Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal

Silva, Dina (författare): Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Portugal

Santana, Isabel (författare): Department of Neurology, Coimbra University Hospital, Coimbra, Portugal

Lemos, Raquel (författare): Faculty of Psychology and Educational Sciences, University of Coimbra, Coimbra, Portugal

Engelborghs, Sebastiaan (författare): Reference Centre for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium

Van der Mussele, Stefan (författare): Reference Centre for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

Freund-Levi, Yvonne, 1956- (författare): Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

Wallin, Åsa (författare): Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups

Hampel, Harald (författare): Centre des Maladies Cognitives et Comportementales, Institut du Cerveau et de la Moelle épinière, Paris, France; Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France

van der Flier, Wiesje (författare): Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Scheltens, Philip (författare): Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Visser, Pieter Jelle (författare): Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; Alzheimer Centre Limburg, Maastricht, The Netherlands; Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Alzheimer’s Disease Neuroimaging Initiative, The (bidragsgivare)

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2015-02-17
2015
Engelska.
Ingår i: Brain. - : Oxford University Press. - 0006-8950 .- 1460-2156. ; 138:5, s. 1327-1338

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Three sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognitive impairment (n = 1607), 766 of whom had both amyloid and neuronal injury markers, were recruited from 13 cohorts. We used cognitive test performance and available biomarkers to classify subjects as prodromal Alzheimer's disease according to International Working Group-1 and International Working Group-2 criteria and in the high Alzheimer's disease likelihood group, conflicting biomarker groups (isolated amyloid pathology or suspected non-Alzheimer pathophysiology), and low Alzheimer's disease likelihood group according to the National Institute of Ageing-Alzheimer Association criteria. Outcome measures were the proportion of subjects with Alzheimer's disease at the mild cognitive impairment stage and progression to Alzheimer's disease-type dementia. We performed survival analyses using Cox proportional hazards models. According to the International Working Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. According to the International Working Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease. According to the National Institute of Ageing-Alzheimer Association criteria, 353 (46%) subjects were in the high Alzheimer's disease likelihood group, 49 (6%) in the isolated amyloid pathology group, 220 (29%) in the suspected non-Alzheimer pathophysiology group, and 144 (19%) in the low Alzheimer's disease likelihood group. The 3-year progression rate to Alzheimer's disease-type dementia was 59% in the high Alzheimer's disease likelihood group, 22% in the isolated amyloid pathology group, 24% in the suspected non-Alzheimer pathophysiology group, and 5% in the low Alzheimer's disease likelihood group. Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage. In clinical settings, the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis. For clinical trials, selection of subjects in the National Institute of Ageing-Alzheimer Association high Alzheimer's disease likelihood group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.

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Av författaren/redakt...: Vos, Stephanie J ...; Verhey, Frans; Frölich, Lutz; Kornhuber, Johan ...; Wiltfang, Jens; Maier, Wolfgang; visa fler...; Peters, Oliver; Rüther, Eckart; Nobili, Flavio; Morbelli, Silvia; Frisoni, Giovann ...; Drzezga, Alexand ...; Didic, Mira; van Berckel, Bar ...; Simmons, Andrew; Soininen, Hilkka; Kłoszewska, Iwon ...; Mecocci, Patrizi ...; Tsolaki, Magda; Vellas, Bruno; Lovestone, Simon; Muscio, Cristina; Herukka, Sanna-K ...; Salmon, Eric; Bastin, Christin ...; Wallin, Anders, ...; Nordlund, Arto, ...; de Mendonça, Ale ...; Silva, Dina; Santana, Isabel; Lemos, Raquel; Engelborghs, Seb ...; Van der Mussele, ...; Freund-Levi, Yvo ...; Wallin, Åsa; Hampel, Harald; van der Flier, W ...; Scheltens, Phili ...; Visser, Pieter J ...; Alzheimer’s Dise ...; visa färre...

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Av lärosätet: Örebro universitet; Lunds universitet; Göteborgs universitet; Karolinska Institutet

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Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage

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