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Sökning: onr:"swepub:oai:DiVA.org:umu-210278" > Dissecting the gene...

Dissecting the genetic heterogeneity of gastric cancer

Hess, Timo (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Maj, Carlo (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany; Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
Gehlen, Jan (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany
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Borisov, Oleg (författare)
Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
Haas, Stephan L. (författare)
Karolinska Institutet
Gockel, Ines (författare)
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
Vieth, Michael (författare)
Institute for Pathology, Friedrich-Alexander-University Erlangen-Nuernberg, Klinikum Bayreuth, Bayreuth, Germany
Piessen, Guillaume (författare)
Department of Digestive and Oncological Surgery, Claude Huriez Hospital, CHU Lille, Lille, France
Alakus, Hakan (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
Vashist, Yogesh (författare)
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany; Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Pereira, Carina (författare)
Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO Porto), Porto, Portugal; Porto Comprehensive Cancer Center & RISE @ CI-IPO, University of Porto, Porto, Portugal
Knapp, Michael (författare)
Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
Schüller, Vitalia (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany
Quaas, Alexander (författare)
Medical Faculty, Institute of Pathology, University Hospital Cologne, University of Cologne, Germany
Grabsch, Heike I. (författare)
Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands; Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
Trautmann, Jessica (författare)
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Malecka-Wojciesko, Ewa (författare)
Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
Mokrowiecka, Anna (författare)
Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
Speller, Jan (författare)
Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
Mayr, Andreas (författare)
Medical Faculty, Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), University of Bonn, Bonn, Germany
Schröder, Julia (författare)
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Hillmer, Axel M. (författare)
Medical Faculty, Institute of Pathology, University Hospital Cologne, University of Cologne, Germany
Heider, Dominik (författare)
Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany
Lordick, Florian (författare)
University Cancer Center Leipzig, Leipzig University Medical Center, Leipzig, Germany
Pérez-Aísa, Ángeles (författare)
Department of Gastroenterology, Hospital Costa del Sol, Marbella, Spain
Campo, Rafael (författare)
Department of Gastroenterology, Hospital Parc Tauli, Sabadell, Spain
Espinel, Jesús (författare)
Department of Gastroenterology, Complejo Hospitalario, León, Spain
Geijo, Fernando (författare)
Department of Gastroenterology, Hospital Clínico Universitario, Salamanca, Spain
Thomson, Concha (författare)
Department of Gastroenterology, Hospital Obispo Polanco, Teruel, Spain
Bujanda, Luis (författare)
CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Universidad del País Vasco (UPV/EHU), San Sebastián, Spain
Sopeña, Federico (författare)
CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
Lanas, Ángel (författare)
CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain
Pellisé, María (författare)
CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Department of Gastroenterology, Hospital Clinic of Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Pauligk, Claudia (författare)
Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
Goetze, Thorsten Oliver (författare)
Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
Zelck, Carolin (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany
Reingruber, Julian (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany
Hassanin, Emadeldin (författare)
Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
Elbe, Peter (författare)
Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Stockholm, Sweden
Alsabeah, Sandra (författare)
Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital and Unit of Gastroenterology and Rheumatology, Stockholm, Sweden
Lindblad, Mats (författare)
Division of Surgery, Department of Upper GI Diseases, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Nilsson, Magnus (författare)
Karolinska Institutet
Kreuser, Nicole (författare)
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
Thieme, René (författare)
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany
Tavano, Francesca (författare)
Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Pastorino, Roberta (författare)
Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Arzani, Dario (författare)
Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy
Persiani, Roberto (författare)
Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Jung, Jin-On (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Nienhüser, Henrik (författare)
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Ott, Katja (författare)
Department of Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany
Schumann, Ralf R. (författare)
Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Kumpf, Oliver (författare)
Department of Anaesthesiology and Operative Intensive Care Medicine, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
Burock, Susen (författare)
Charité Comprehensive Cancer Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Jakubowska, Anna (författare)
Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Poland; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University in Szczecin, Poland
Ławniczak, Małgorzta (författare)
Department of Gastroenterology, Pomeranian Medical University in Szczecin, Poland
Moreno, Victor (författare)
Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Hospital Duran I Reynals, Barcelona, Spain; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Faculty of Medicine, Department of Clinical Sciences, University of Barcelona, Barcelona, Spain
Martín, Vicente (författare)
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; The Research Group in Gene - Environment and Health Interactions (GIIGAS)/Institute of Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain; Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de Leon, Leon, Spain
Kogevinas, Manolis (författare)
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Campus Del Mar, Barcelona, Spain; IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain
Pollán, Marina (författare)
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Dąbrowska, Justyna (författare)
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
Salas, Antonio (författare)
Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain
Cussenot, Olivier (författare)
CeRePP, Paris, France; GRC n°5 Predictive Onco-Urology, Tenon Hospital, Sorbonne University, Paris, France
Boland-Auge, Anne (författare)
Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
Daian, Delphine (författare)
Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
Deleuze, Jean-Francois (författare)
Centre National de Recherche en Génomique Humaine, CEA, University Paris-Saclay, Evry, France
Salvi, Erika (författare)
Neuroalgology Unit Fondazione IRCCS, Instituto Neurologico 'Carlo Besta' Milan, Milan, Italy
Teder-Laving, Maris (författare)
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
Tomasello, Gianluca (författare)
Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Ratti, Margherita (författare)
Medical Oncology Unit, ASST of Cremona, Cremona, Italy
Senti, Chiara (författare)
Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Department of Medical Oncology, Institut Jules Bordet - Université Libre de Bruxelles (ULB), Brussels, Belgium
De Re, Valli (författare)
Unit of Immunopathologia e Biomarcatori Oncologici/Bio-proteomics Facility, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
Steffan, Agostino (författare)
Unit of Immunopathologia e Biomarcatori Oncologici, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
Hölscher, Arnulf H. (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
Messerle, Katharina (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
Bruns, Christiane Josephine (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany
Sīviņš, Armands (författare)
Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia
Bogdanova, Inga (författare)
Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia
Skieceviciene, Jurgita (författare)
Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
Arstikyte, Justina (författare)
Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
Moehler, Markus (författare)
Department of Medicine I, University Medical Center of Johannes Gutenberg University Mainz, Mainz, Germany
Lang, Hauke (författare)
Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany
Grimminger, Peter P. (författare)
Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany
Kruschewski, Martin (författare)
Department of General and Visceral Surgery, Klinikum Frankfurt (Oder), Germany
Vassos, Nikolaos (författare)
Division of Surgical Oncology and Thoracic Surgery, Department of Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
Schildberg, Claus (författare)
Department of General Surgery, Brandenburg Medical School Theodor Fontane, University Hospital Brandenburg, Brandenburg, Germany
Lingohr, Philipp (författare)
Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Bonn, Germany
Ridwelski, Karsten (författare)
Department of General and Visceral Surgery, Klinikum Magdeburg GmbH, Magdeburg, Germany
Lippert, Hans (författare)
Institute of Quality Assurance in Operative Medicine, Otto-von-Guericke University Hospital, Magdeburg, Germany
Fricker, Nadine (författare)
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
Krawitz, Peter (författare)
Medical Faculty, Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany
Hoffmann, Per (författare)
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
Nöthen, Markus M. (författare)
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany
Veits, Lothar (författare)
Institute for Pathology, Friedrich-Alexander-University Erlangen-Nuernberg, Klinikum Bayreuth, Bayreuth, Germany
Izbicki, Jakob R. (författare)
Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany
Mostowska, Adrianna (författare)
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
Martinón-Torres, Federico (författare)
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain; Department of Pediatrics, Translational Pediatrics and Infectious Diseases Section, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Spain; Genetics, Vaccines, Infectious Diseases and Pediatrics Research Group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Cusi, Daniele (författare)
Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy; Bio4Dreams-Business, Nursery for Life Sciences, Milan, Italy
Adolfsson, Rolf (författare)
Umeå universitet,Psykiatri
Cancel-Tassin, Geraldine (författare)
CeRePP, Paris, France; GRC n°5 Predictive Onco-Urology, Tenon Hospital, Sorbonne University, Paris, France
Höblinger, Aksana (författare)
Department of Internal Medicine I, Community Hospital Mittelrhein, Koblenz, Germany
Rodermann, Ernst (författare)
Association of Medical Practices in Hematology and Internal Oncology, Troisdorf, Germany
Ludwig, Monika (författare)
Association for Oncological Studies (Gefos), Dortmund, Germany
Keller, Gisela (författare)
Institute of Pathology, Technical University of Munich, Munich, Germany
Metspalu, Andres (författare)
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Heller, Joerg (författare)
Department of Gastroenterology, Marienhaus Hospital Ahrweiler, Ahrweiler, Germany
Neef, Markus (författare)
Department of Gastroenterology, Helios Hospital Siegburg, Siegburg, Germany
Schepke, Michael (författare)
Department of Gastroenterology, Helios Hospital Siegburg, Siegburg, Germany
Dumoulin, Franz Ludwig (författare)
Department of Gastroenterology, St. Elisabeth Hospital Bonn, Bonn, Germany
Hamann, Lutz (författare)
Institute of Microbiology, Infectious Diseases and Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Cannizzaro, Renato (författare)
Unit of Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
Ghidini, Michele (författare)
Medical Oncology Unit, ASST of Cremona, Cremona, Italy; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Plaßmann, Dominik (författare)
Gastroenterological Centre, Dr. Plaßmann, Bonn, Germany
Geppert, Michael (författare)
Gastroenterological Centre, Dr. Geppert, Bayreuth, Germany
Malfertheiner, Peter (författare)
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany; Department of Internal Medicine II, Hospital of the Ludwig Maximilians University of Munich, Munich, Germany
Gehlen, Olivier (författare)
Department of Surgical Oncology, Centre Hospitalier Lyon-sud, Lyon, France
Skoczylas, Tomasz (författare)
2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland
Majewski, Marek (författare)
2nd Department of General Surgery, Medical University of Lublin, Lublin, Poland
Lubiński, Jan (författare)
Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Poland
Palmieri, Orazio (författare)
Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Boccia, Stefania (författare)
Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy
Latiano, Anna (författare)
Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Aragones, Nuria (författare)
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública e CIBERESP), Spain; Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
Schmidt, Thomas (författare)
Department of General, Visceral, Cancer and Transplant Surgery, University of Cologne, Cologne, Germany; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Dinis-Ribeiro, Mário (författare)
Porto Comprehensive Cancer Center & RISE @ CI-IPO, University of Porto, Porto, Portugal; Gastroenterology Department, Portuguese Institute of Oncology of Porto, Porto, Portugal
Medeiros, Rui (författare)
Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO Porto), Porto, Portugal; Research Department of the Portuguese League Against Cancer-North (LPCC-NRNorte), Porto, Portugal
Al-Batran, Salah-Eddin (författare)
Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany; Institut für Klinische Krebsforschung IKF GmbH am Krankenhaus Nordwest, Frankfurt, Germany
Leja, Mārcis (författare)
Institute of Clinical and Preventive Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia; Digestive Diseases Centre GASTRO, Riga, Latvia
Kupcinskas, Juozas (författare)
Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
García-González, María A. (författare)
CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain; Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain
Venerito, Marino (författare)
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany
Schumacher, Johannes (författare)
Institute of Human Genetics, University of Marburg, Marburg, Germany
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 (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 92
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture.Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO.Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level.Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

Gastric cancer
Genome-wide association study (GWAS)
Oesophageal adenocarcinoma
Transcriptome-wide association study (TWAS)

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