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Sökning: WFRF:(Lundberg Staffan 1956 ) > Rolandic Epilepsy :

Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study

Lundberg, Staffan, 1956- (författare)
Uppsala universitet,Institutionen för kvinnors och barns hälsa
Eeg-Olofsson, Orvar (preses)
Raininko, Raili (preses)
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Stephani, Ulrich, Professor (opponent)
University Department of Neuropediatrics, Kiel
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 (creator_code:org_t)
ISBN 9155459102
Uppsala : Acta Universitatis Upsaliensis, 2004
Engelska 80 s.
Serie: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 1332
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
Stäng  
  • Rolandic epilepsy (RE) is the most common focal epilepsy syndrome in the pediatric age group with an onset between 3 and 13 years. The syndrome is defined by electro-clinically typical features and has been considered benign according to seizure remission before the age of 16 years.The aim of this thesis was to investigate children with typical RE with different methods and to discuss the delineation of the syndrome. Thirty-eight children, aged 6–14 years, participated in one up to four studies.Eighteen children were investigated with MRI. Hippocampal abnormalities were found in six (33%), volume asymmetry in five (28%) and high signal intensities on T2-weighted images in three (17%). Additionally, high signal intensities in T2-weighted images were revealed subcortically in temporal and frontal lobes bilaterally in five children (28%).The hippocampal region was evaluated metabolically using proton magnetic resonance spectroscopy (1H-MRS) in 13 children with RE and 15 matched controls. A metabolic asymmetry of the hippocampal regions was found in the patients compared to controls indicating an abnormal neuronal function.Seventeen children with RE and 17 matched controls were investigated with a neuropsychological test battery. The RE children showed lower performance in auditory-verbal tests and in executive functions compared to controls.Twenty RE children and 24 controls were assessed concerning their oromotor function. The RE children had greater problems concerning tongue movements including articulation. A dichotic listening test was also performed in a subgroup showing poorer results in the RE group. A simple classification is proposed with RE ‘pure’ as the main group and the frame for this study.In conclusion, these investigations disclosed various abnormalities in children with RE, challenging the benign concept during the active phase. It is assumed that maturational factors comprise causal mechanism to the deviant findings, which probably successively will normalize.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Nyckelord

Pediatrics
rolandic epilepsy
children
idiopathic focal epilepsy
magnetic resonance imaging
proton magnetic resonance spectroscopy
cognition
neuropsychology
oromotor performance
dichotic listening
hippocampus
classification
Pediatrik
Paediatric medicine
Pediatrisk medicin

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