Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study

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Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study

Di Castelnuovo, Augusto (författare): Mediterranea Cardiocentro, Napoli, Italy

Costanzo, Simona (författare): Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

Bonaccio, Marialaura (författare): Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

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McElduff, Patrick (författare): University of Newcastle & Hunter Medical Research Institute, Australia

Linneberg, Allan (författare): Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Salomaa, Veikko (författare): Finnish Institute for Health and Welfare, Helsinki, Finland

Männistö, Satu (författare): Finnish Institute for Health and Welfare, Helsinki, Finland

Moitry, Marie (författare): Department of Public Health, University Hospital of Strasbourg and Department of Epidemiology and Public Health, University of Strasbourg, France

Ferrières, Jean (författare): Department of Cardiology and INSERM UMR 1295, Toulouse University Hospital, Toulouse, France

Dallongeville, Jean (författare): University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France

Thorand, Barbara (författare): Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany

Brenner, Hermann (författare): Division of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany

Ferrario, Marco (författare): Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy

Veronesi, Giovanni (författare): Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy

Pettenuzzo, Emanuela (författare): Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy

Tamosiunas, Abdonas (författare): Lithuanian University of Health Sciences, Kaunas, Lithuania

Njølstad, Inger (författare): Department of community Medicine, University of Tromsø - the Arctic University of Norway, Norway

Drygas, Wojciech (författare): Department of Epidemiology CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland

Nikitin, Yuri (författare): The Institute of Internal and Preventive Medicine, Novosibirsk, Russian Federation

Söderberg, Stefan (författare): Umeå universitet,Avdelningen för medicin

Kee, Frank (författare): Centre for Public Health, Queens University of Belfast, Belfast, United Kingdom

Grassi, Guido (författare): Clinica Medica, Università Milano-Bicocca, Milano, Italy

Westermann, Dirk (författare): Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Schrage, Benedikt (författare): Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Dabboura, Salim (författare): Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Zeller, Tanja (författare): Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Kuulasmaa, Kari (författare): Finnish Institute for Health and Welfare, Helsinki, Finland

Blankenberg, Stefan (författare): Clinic of General and Interventional Cardiology, University Heart & Vascular Center Hamburg, Germany, and German Center for cardiovascular research, Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany

Donati, Maria Benedetta (författare): Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

de Gaetano, Giovanni (författare): Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

Iacoviello, Licia (författare): Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy

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(creator_code:org_t)

2021-07-08
2022
Engelska.
Ingår i: Addiction. - : John Wiley & Sons. - 0965-2140 .- 1360-0443. ; 117:2, s. 312-325

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://onlinelibrar...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Aim: To test the association of alcohol consumption with total and cause-specific mortality risk. Design: Prospective observational multi-centre population-based study.Setting: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.Participants: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).Measurements: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.Findings: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7–14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7–20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10–35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.Conclusions: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)

Nyckelord

Alcohol intake
cancer mortality
cardiovascular mortality
cohort study
HDL cholesterol
mortality

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Av lärosätet: Umeå universitet

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