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Search: WFRF:(MacGregor Stuart) > (2010-2014) > A variant in FTO sh...

A variant in FTO shows association with melanoma risk not due to BMI

Iles, Mark M. (author)
Law, Matthew H. (author)
Stacey, Simon N. (author)
show more...
Han, Jiali (author)
Fang, Shenying (author)
Pfeiffer, Ruth (author)
Harland, Mark (author)
MacGregor, Stuart (author)
Taylor, John C. (author)
Aben, Katja K. (author)
Akslen, Lars A. (author)
Avril, Marie-Francoise (author)
Azizi, Esther (author)
Bakker, Bert (author)
Benediktsdottir, Kristrun R. (author)
Bergman, Wilma (author)
Scarra, Giovanna Bianchi (author)
Brown, Kevin M. (author)
Calista, Donato (author)
Chaudru, Valerie (author)
Fargnoli, Maria Concetta (author)
Cust, Anne E. (author)
Demenais, Florence (author)
Waal, Anne C. de (author)
Debniak, Tadeusz (author)
Elder, David E. (author)
Friedman, Eitan (author)
Galan, Pilar (author)
Ghiorzo, Paola (author)
Gillanders, Elizabeth M. (author)
Goldstein, Alisa M. (author)
Gruis, Nelleke A. (author)
Hansson, Johan (author)
Karolinska Institutet
Helsing, Per (author)
Hocevar, Marko (author)
Hoiom, Veronica (author)
Karolinska Institutet
Hopper, John L. (author)
Ingvar, Christian (author)
Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Janssen, Marjolein (author)
Jenkins, Mark A. (author)
Kanetsky, Peter A. (author)
Kiemeney, Lambertus A. (author)
Lang, Julie (author)
Lathrop, G. Mark (author)
Leachman, Sancy (author)
Lee, Jeffrey E. (author)
Lubinski, Jan (author)
Mackie, Rona M. (author)
Mann, Graham J. (author)
Martin, Nicholas G. (author)
Mayordomo, Jose I. (author)
Molven, Anders (author)
Mulder, Suzanne (author)
Nagore, Eduardo (author)
Novakovic, Srdjan (author)
Okamoto, Ichiro (author)
Olafsson, Jon H. (author)
Olsson, Håkan (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Pehamberger, Hubert (author)
Peris, Ketty (author)
Grasa, Maria Pilar (author)
Planelles, Dolores (author)
Puig, Susana (author)
Puig-Butille, Joan Anton (author)
Randerson-Moor, Juliette (author)
Requena, Celia (author)
Rivoltini, Licia (author)
Rodolfo, Monica (author)
Santinami, Mario (author)
Sigurgeirsson, Bardur (author)
Snowden, Helen (author)
Song, Fengju (author)
Sulem, Patrick (author)
Thorisdottir, Kristin (author)
Tuominen, Rainer (author)
Karolinska Institutet
Van Belle, Patricia (author)
van der Stoep, Nienke (author)
van Rossum, Michelle M. (author)
Wei, Qingyi (author)
Wendt, Judith (author)
Zelenika, Diana (author)
Zhang, Mingfeng (author)
Landi, Maria Teresa (author)
Thorleifsson, Gudrnar (author)
Bishop, D. Timothy (author)
Amos, Christopher I. (author)
Hayward, Nicholas K. (author)
Stefansson, Kari (author)
Bishop, Julia A. Newton (author)
Barrett, Jennifer H. (author)
show less...
 (creator_code:org_t)
2013-03-03
2013
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:4, s. 428-432
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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By the author/editor
Iles, Mark M.
Law, Matthew H.
Stacey, Simon N.
Han, Jiali
Fang, Shenying
Pfeiffer, Ruth
show more...
Harland, Mark
MacGregor, Stuar ...
Taylor, John C.
Aben, Katja K.
Akslen, Lars A.
Avril, Marie-Fra ...
Azizi, Esther
Bakker, Bert
Benediktsdottir, ...
Bergman, Wilma
Scarra, Giovanna ...
Brown, Kevin M.
Calista, Donato
Chaudru, Valerie
Fargnoli, Maria ...
Cust, Anne E.
Demenais, Floren ...
Waal, Anne C. de
Debniak, Tadeusz
Elder, David E.
Friedman, Eitan
Galan, Pilar
Ghiorzo, Paola
Gillanders, Eliz ...
Goldstein, Alisa ...
Gruis, Nelleke A ...
Hansson, Johan
Helsing, Per
Hocevar, Marko
Hoiom, Veronica
Hopper, John L.
Ingvar, Christia ...
Janssen, Marjole ...
Jenkins, Mark A.
Kanetsky, Peter ...
Kiemeney, Lamber ...
Lang, Julie
Lathrop, G. Mark
Leachman, Sancy
Lee, Jeffrey E.
Lubinski, Jan
Mackie, Rona M.
Mann, Graham J.
Martin, Nicholas ...
Mayordomo, Jose ...
Molven, Anders
Mulder, Suzanne
Nagore, Eduardo
Novakovic, Srdja ...
Okamoto, Ichiro
Olafsson, Jon H.
Olsson, Håkan
Pehamberger, Hub ...
Peris, Ketty
Grasa, Maria Pil ...
Planelles, Dolor ...
Puig, Susana
Puig-Butille, Jo ...
Randerson-Moor, ...
Requena, Celia
Rivoltini, Licia
Rodolfo, Monica
Santinami, Mario
Sigurgeirsson, B ...
Snowden, Helen
Song, Fengju
Sulem, Patrick
Thorisdottir, Kr ...
Tuominen, Rainer
Van Belle, Patri ...
van der Stoep, N ...
van Rossum, Mich ...
Wei, Qingyi
Wendt, Judith
Zelenika, Diana
Zhang, Mingfeng
Landi, Maria Ter ...
Thorleifsson, Gu ...
Bishop, D. Timot ...
Amos, Christophe ...
Hayward, Nichola ...
Stefansson, Kari
Bishop, Julia A. ...
Barrett, Jennife ...
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Surgery
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Nature Genetics
By the university
Lund University
Karolinska Institutet

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