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Atherosclerosis in ...
Atherosclerosis in rheumatoid arthritis : associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness
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- Wahlin, Bengt (author)
- Umeå universitet,Reumatologi
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Fasth, Andreas (author)
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- Karp, Kjell (author)
- Umeå universitet,Klinisk fysiologi
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- Lejon, Kristina, 1967- (author)
- Umeå universitet,Immunologi/immunkemi
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- Malmström, Vivianne (author)
- Karolinska Institutet
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- Rahbar, Afsar (author)
- Karolinska Institutet
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- Wållberg-Jonsson, Solveig, 1953- (author)
- Umeå universitet,Reumatologi
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- Södergren, Anna, 1977- (author)
- Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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(creator_code:org_t)
- Clinical and Experimental Rheumatology S.A.S. 2021
- 2021
- English.
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In: Clinical and Experimental Rheumatology. - : Clinical and Experimental Rheumatology S.A.S.. - 0392-856X .- 1593-098X. ; 39:3, s. 578-586
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.5...
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http://kipublication...
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Abstract
Subject headings
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- Objectives: Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aims of this study were to study the associations between subsets of T-cells, subclinical atherosclerosis assessed by intima-media thickness (IMT) and serological status for CMV in patients with RA.Methods: Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were included in a prospective study of atherosclerosis. Controls matched for age and sex were also included (n=44). Ultrasound measurement of IMT in the common carotid artery was undertaken at inclusion (T0), after 1.5 years (T1.5) and after 11 years (T11). At T11, flow-cytometry analysis was undertaken to investigate subsets of T-cells. Serological analysis for CMV was undertaken from samples collected at T0.Results: At T0, 66% of the patients and controls were CMV immunoglobulin G-positive. CMV-IgG positive patients had a significantly more rapid increase in IMT at T1.5, compared with controls and CMV-IgG negative patients. CMV-IgG positive patients had a significantly higher percentage of T-cells lacking CD28 (both CD4+CD28null and CD8+CD28null T-cells) than CMV-IgG negative patients. Increased levels of CD4+CD28null and CD8+CD28null T-cells were significantly associated with IMT at T11, adjusted for systolic blood pressure. CX3CR1 was expressed in CD4+ and CD8+ CD28null T-cells, but CX3CR1 per se was not associated with increased IMT.Conclusions: Presence of CMV IgG-antibodies in patients with RA is associated with altered T-cell-populations and an increased burden of atherosclerosis. A possible protective effect of antiviral treatment in CMV-positive patients with new-onset RA should be considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- rheumatoid arthritis
- atherosclerosis
- T-cells
- CD28
- cytomegalovirus
Publication and Content Type
- ref (subject category)
- art (subject category)
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