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Sökning: onr:"swepub:oai:lup.lub.lu.se:5d2077f0-1ddb-4387-bedd-5d50b87c515f" > Tailored approaches...

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Baliakas, Panagiotis, 1977- (författare)
Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
Moysiadis, Theodoros (författare)
Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
Hadzidimitriou, Anastasia (författare)
Uppsala universitet,Uppsala University,Center for Research and Technology Hellas,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
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Xochelli, Aliki (författare)
Uppsala universitet,Uppsala University,Center for Research and Technology Hellas,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
Jeromin, Sabine (författare)
Munich Leukemia Laboratory (MLL),MLL Munich Leukemia Lab, Munich, Germany
Agathangelidis, Andreas (författare)
Karolinska Institutet,Center for Research and Technology Hellas
Mattsson, Mattias (författare)
Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
Sutton, Lesley Ann (författare)
Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
Minga, Eva (författare)
Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
Scarfò, Lydia (författare)
Vita-Salute San Raffaele University,San Raffaele Scientific Institute,IRCCS Ist Sci San Raffaele, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
Rossi, Davide (författare)
Oncology Institute of Southern Switzerland,Oncol Inst Southern Switzerland, Bellinzona, Switzerland
Davis, Zadie (författare)
Royal Bournemouth Hospital,Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
Villamor, Neus (författare)
Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain
Parker, Helen (författare)
University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
Kotaskova, Jana (författare)
University Hospital Brno,Masaryk University,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
Stalika, Evangelia (författare)
George Papanicolaou General Hospital,Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece;G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
Plevova, Karla (författare)
Masaryk University,University Hospital Brno,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
Mansouri, Larry (författare)
Karolinska Institutet,Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
Cortese, Diego (författare)
Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
Navarro, Alba (författare)
Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain
Delgado, Julio (författare)
Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain
Larrayoz, Marta (författare)
University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
Young, Emma (författare)
Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
Anagnostopoulos, Achilles (författare)
George Papanicolaou General Hospital,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
Smedby, Karin E. (författare)
Karolinska Institutet,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden
Juliusson, Gunnar (författare)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ & Hosp, Lund Stem Cell Ctr, Dept Hematol, Lund, Sweden
Sheehy, Oonagh (författare)
Belfast City Hospital,Belfast City Hosp, Dept Hematooncol, Belfast, Antrim, North Ireland
Catherwood, Mark (författare)
Belfast City Hospital,Belfast City Hosp, Dept Hematooncol, Belfast, Antrim, North Ireland
Strefford, Jonathan C. (författare)
University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
Stavroyianni, Niki (författare)
George Papanicolaou General Hospital,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
Belessi, Chrysoula (författare)
Nikea General Hospital, Piraeus,Nikea Gen Hosp, Hematol Dept, Piraeus, Greece
Pospisilova, Sarka (författare)
Masaryk University,University Hospital Brno,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
Oscier, David (författare)
Royal Bournemouth Hospital,Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
Gaidano, Gianluca (författare)
University of Eastern Piedmont,Amedeo Avogadro Univ Eastern Piedmont, Dept Translat Med, Div Hematol, Novara, Italy
Campo, Elias (författare)
Hospital Clínic of Barcelona,University of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain;Univ Barcelona, Dept Pathol, Barcelona, Spain
Haferlach, Claudia (författare)
Munich Leukemia Laboratory (MLL),MLL Munich Leukemia Lab, Munich, Germany
Ghia, Paolo (författare)
Vita-Salute San Raffaele University,San Raffaele Scientific Institute,IRCCS Ist Sci San Raffaele, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
Rosenquist, Richard (författare)
Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
Stamatopoulos, Kostas (författare)
Uppsala University,Center for Research and Technology Hellas,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden
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 (creator_code:org_t)
 
2018-09-27
2019
Engelska 10 s.
Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 104:2, s. 360-369
Relaterad länk:
http://dx.doi.org/10... (free)
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https://doi.org/10.3...
https://doi.org/10.3...
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https://lup.lub.lu.s...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicators may differ between these two categories. Within Binet A M-CLL patients, besides TP53 abnormalities, trisomy 12 and stereotyped subset #2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years after diagnosis of 40% and 55%, respectively; the remaining cases exhibited 5-year and 10-year treatment probability of 12% and 25%, respectively. Within Binet A U-CLL patients, besides TP53 abnormalities, del(11q) and/or SF3B1 mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respectively); in the remaining cases, males had a significantly worse prognosis than females. In conclusion, the relative weight of indicators that can accurately risk stratify early-stage CLL patients differs depending on the somatic hypermutation status of the immunoglobulin heavy variable genes of each patient. This finding highlights the fact that compartmentalized approaches based on immunogenetic features are necessary to refine and tailor prognostication in CLL.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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