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Cardiovascular risk...
Cardiovascular risk factors and ischemic heart disease
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- Elosua, Roberto (författare)
- Hospital del Mar Medical Research Institute
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- Lluís-Ganella, Carla (författare)
- Hospital del Mar Medical Research Institute
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- Subirana, Isaac (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Havulinna, Aki (författare)
- Finnish National Institute for Health and Welfare
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- Läll, Kristi (författare)
- University of Tartu
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- Lucas, Gavin (författare)
- Hospital del Mar Medical Research Institute
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- Sayols-Baixeras, Sergi (författare)
- Hospital del Mar Medical Research Institute
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- Pietilä, Arto (författare)
- Finnish National Institute for Health and Welfare
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- Alver, Maris (författare)
- University of Tartu
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- De León, Antonio Cabrera (författare)
- University of La Laguna (ULL)
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- Sentí, Mariano (författare)
- Pompeu Fabra University
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- Siscovick, David (författare)
- New York Academy of Medicine
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Fischer, Krista (författare)
- University of Tartu
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- Salomaa, Veikko (författare)
- Finnish National Institute for Health and Welfare
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- Marrugat, Jaume (författare)
- Hospital del Mar Medical Research Institute
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(creator_code:org_t)
- 2016
- 2016
- Engelska 8 s.
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Ingår i: Circulation: Cardiovascular Genetics. - 1942-325X. ; 9:3, s. 279-286
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background - Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk factor confluence on ischemic heart disease (IHD) risk by testing whether genetic risk scores (GRSs) associated with these factors interact on an additive or multiplicative scale, and to determine whether these interactions provide additional value for predicting IHD risk. Methods and Results - We selected genetic variants associated with blood pressure, body mass index, waist circumference, triglycerides, type-2 diabetes mellitus, high-density lipoprotein and low-density lipoprotein cholesterol, and IHD to create GRSs for each factor. We tested and meta-analyzed the impact of additive (synergy index) and multiplicative (β interaction) interactions between each GRS pair in 1 case-control (n=6042) and 4 cohort studies (n=17 794) and evaluated the predictive value of these interactions. We observed 2 multiplicative interactions: GRS LDL ·GRS Triglycerides (β interaction =-0.096; SE=0.028) and nonpleiotropic GRS IHD ·GRS LDL (β interaction =0.091; SE=0.028). Inclusion of these interaction terms did not improve predictive capacity. Conclusions - The confluence of low-density lipoprotein cholesterol and triglycerides genetic risk load has an additive effect on IHD risk. The interaction between low-density lipoprotein cholesterol and IHD genetic load is more than multiplicative, supporting the hazardous impact on atherosclerosis progression of the combination of inflammation and increased lipid levels. The capacity of risk factor confluence to improve IHD risk prediction is questionable. Further studies in larger samples are warranted to confirm and expand our results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- genetic association studies
- genetic variation
- regression analysis
- risk assessment
- risk factors
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- ref (ämneskategori)
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Elosua, Roberto
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Lluís-Ganella, C ...
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Subirana, Isaac
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Havulinna, Aki
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Läll, Kristi
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Lucas, Gavin
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visa fler...
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Sayols-Baixeras, ...
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Pietilä, Arto
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Alver, Maris
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De León, Antonio ...
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Sentí, Mariano
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Siscovick, David
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Melander, Olle
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Fischer, Krista
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Salomaa, Veikko
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Marrugat, Jaume
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation: Car ...
- Av lärosätet
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Lunds universitet