Sökning: WFRF:(Marth C) >
Associations of who...
Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents
-
Marth, S. (författare)
-
Börnhorst, C. (författare)
-
- Mehlig, Kirsten, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
-
visa fler...
-
Russo, P. (författare)
-
Moreno, L. A. (författare)
-
De Henauw, S. (författare)
-
Veidebaum, T. (författare)
-
Molnár, D. (författare)
-
Tornaritis, M. (författare)
-
Risé, P. (författare)
-
Wolters, M. (författare)
-
on behalf of the, Idefics (författare)
-
I. Family consortia, I. Family consortia (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-04-08
- 2020
- Engelska.
-
Ingår i: European Journal of Pediatrics. - : Springer Science and Business Media LLC. - 0340-6199 .- 1432-1076. ; 179, s. 1647-1651
- Relaterad länk:
-
https://link.springe...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- This study aims to examine the association of whole blood n-3 and n-6 polyunsaturated fatty acids (PUFA) with insulin resistance (IR) in children. Whole blood fatty acids were measured in 705 children aged 2–9years of the European IDEFICS/I.Family cohort using gas chromatography in units of weight percentage of all detected fatty acids (%wt/wt). IR was determined by the Homeostasis Model Assessment for IR (HOMA). Mixed effect models were used to assess the associations between selected baseline PUFA and HOMA z-scores at baseline and after 2- and 6-year follow-ups using models with basic and additional confounder adjustment as well as stratified by sex and weight status. In the basic model, α-linolenic (β = 1.46 SD/%wt/wt, p = 0.006) and eicosapentaenoic acid (β = 1.17 SD/%wt/wt, p = 0.001) were positively associated with baseline HOMA z-score. In the stratified analyses, α-linolenic acid was positively associated with HOMA z-score in girls only (β = 1.98 SD/%wt/wt, p = 0.006) and arachidonic acid was inversely associated with baseline HOMA in thin/normal-weight children (β = − 0.13 SD/%wt/wt, p = 0.0063). In the fully adjusted model, no statistically significant associations were seen. Conclusions: Our overall results do not indicate a protective role of higher blood n-3 PUFA or an adverse role of higher blood arachidonic acid proportion on the risk of IR.What is Known:•Intervention studies reported a beneficial effect of n-3 PUFA supplementation on insulin resistance compared with placebo while observational studies in cildren are inconclusive.•Studies have shown a positive association of n-6 arachidonic acid and insulin resistance indicating an adverse role of arachidonic acid.What is New:•Cross-sectional and longitudinal analyses based on circulating blood fatty acid concentrations in a large cohort of European children and adolescents.•Overall results do not support a protective role of n-3 PUFA or an adverse role of arachidonic acid in insulin resistance. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Children
- HOMA
- Insulin resistance
- n-3 fatty acids
- n-6 fatty acids
- Polyunsaturated fatty acids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Marth, S.
-
Börnhorst, C.
-
Mehlig, Kirsten, ...
-
Russo, P.
-
Moreno, L. A.
-
De Henauw, S.
-
visa fler...
-
Veidebaum, T.
-
Molnár, D.
-
Tornaritis, M.
-
Risé, P.
-
Wolters, M.
-
on behalf of the ...
-
I. Family consor ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Göteborgs universitet