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Sökning: onr:"swepub:oai:lup.lub.lu.se:f7f3c57b-82e0-4f47-98fa-269a14905f64" > Risk prediction for...

Risk prediction for renal cell Carcinoma : Results from the European Prospective Investigation into Cancer and nutrition (EPIC) prospective cohort study

Singleton, Rosie K. (författare)
School of Public Health, Imperial College London, London, United Kingdom
Heath, Alicia K. (författare)
School of Public Health, Imperial College London, London, United Kingdom
Clasen, Joanna L. (författare)
School of Public Health, Imperial College London, London, United Kingdom
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Scelo, Ghislaine (författare)
Cancer Epidemiology Unit, University of Turin, Turin, Italy
Johansson, Mattias (författare)
International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
Le Calvez-Kelm, Florence (författare)
International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization,International Agency for Research on Cancer, Lyon, France
Liedberg, Fredrik (författare)
Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Institution of Translational Medicine, Lund University, Malmo, Sweden
Ljungberg, Börje, Professor, 1949- (författare)
Umeå universitet,Umeå University,Urologi och andrologi
Harbs, Justin (författare)
Umeå universitet,Umeå University,Diagnostisk radiologi
Olsen, Anja (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark,Aarhus University
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark,Danish Cancer Society
Dahm, Christina C. (författare)
Department of Public Health, Aarhus University, Denmark
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Fortner, Renee T. (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Panico, Salvatore (författare)
Department of Clinical and Surgical Medicine, Federico II University, Naples, Italy
Tagliabue, Giovanna (författare)
Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–ISPRO, Florence, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
Ricceri, Fulvio (författare)
Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO), Italy; Unit of Epidemiology Regional Health Service ASL TO3, Grugliasco (TO), Italy,Azienda Sanitaria Locale Torino 3
Gram, Inger T. (författare)
UiT The Arctic University of Norway, Tromsø,Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway
Santiuste, Carmen (författare)
CIBER Epidemiology and Public Health (CIBERESP),Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Publica (CIBERESP), Spain
Bonet, Catalina (författare)
Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Barcelona, Spain
Rodriguez-Barranco, Miguel (författare)
CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),Escuela Andaluza de Salud Publica (EASP), Granada, Madrid, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigacion Biomedicaen Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain
Schulze, Mattias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DifE), Potsdam, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany,University of Potsdam
Bergmann, Manuela M. (författare)
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke (DifE), Potsdam, Germany
Travis, Ruth C. (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Tzoulaki, Ioanna (författare)
School of Public Health, Imperial College London, London, United Kingdom; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; University of Ioannina Medical School, Ioannina, Greece,University of Ioannina
Riboli, Elio (författare)
School of Public Health, Imperial College London, London, United Kingdom
Muller, David C. (författare)
School of Public Health, Imperial College London, London, United Kingdom
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 (creator_code:org_t)
AACR, 2021
2021
Engelska 6 s.
Ingår i: Cancer Epidemiology Biomarkers and Prevention. - : AACR. - 1055-9965 .- 1538-7755. ; 30:3, s. 507-512
Relaterad länk:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure. Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679–0.721]). Our model had slightly improved discrimination (0.714 [0.694–0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025. Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population. Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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