Anti-CA15.3 and Anti-CA125 Antibodies and ovarian cancer risk : Results from the EPIC cohort

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Anti-CA15.3 and Anti-CA125 Antibodies and ovarian cancer risk : Results from the EPIC cohort

Cramer, Daniel W. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

Fichorova, Raina N. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

Terry, Kathryn L. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard University

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Yamamoto, Hidemi (författare): Brigham and Women's Hospital / Harvard Medical School

Vitonis, Allison F. (författare): Brigham and Women's Hospital / Harvard Medical School

Ardanaz, Eva (författare): CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Aune, Dagfinn (författare): Imperial College London

Boeing, Heiner (författare): German Institute of Human Nutrition

Brandstedt, Jenny (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital

Boutron-Ruault, Marie Christine (författare)

Chirlaque, Maria Dolores (författare): University of Murcia

Dorronsoro, Miren (författare)

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization

Duell, Eric J. (författare): Catalan Institute of Oncology

Gram, Inger T. (författare): UiT The Arctic University of Norway, Tromsø

Gunter, Marc (författare): International Agency for Research on Cancer, World Health Organization

Hansen, Louise (författare): Danish Cancer Society

Idahl, Annika, 1965- (författare): Umeå universitet,Umeå University,Obstetrik och gynekologi

Johnson, Theron (författare): German Cancer Research Centre

Khaw, Kay Tee (författare): University of Cambridge

Krogh, Vittorio (författare): Istituto Nazionale dei Tumori

Kvaskoff, Marina (författare)

Mattiello, Amalia (författare): University of Naples Federico II

Matullo, Giuseppe (författare): University of Turin

Merritt, Melissa A. (författare): Imperial College London

Nodin, Bjorn (författare): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine

Orfanos, Philippos (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Onland-Moret, N. Charlotte (författare): University Medical Center Utrecht

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Peppa, Eleni (författare): Hellenic Health Foundation, Athens

Quiros, J. Ramon (författare): Public Health Directorate

Sanchez-Perez, Maria Jose (författare)

Severi, Gianluca (författare)

Tjønneland, Anne (författare): Danish Cancer Society

Travis, Ruth C. (författare): University of Oxford

Trichopoulou, Antonia (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Tumino, Rosario (författare)

Weiderpass, Elisabete (författare): Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research

Fortner, Renee T. (författare): German Cancer Research Centre

Kaaks, Rudolf (författare): German Cancer Research Centre

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(creator_code:org_t)

American Association for Cancer Research, 2018
2018
Engelska 15 s.
Ingår i: Cancer Epidemiology Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 27:7, s. 790-804

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC.

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Cancer Epidemiology Biomarkers and Prevention (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Cramer, Daniel W ...; Fichorova, Raina ...; Terry, Kathryn L ...; Yamamoto, Hidemi; Vitonis, Allison ...; Ardanaz, Eva; visa fler...; Aune, Dagfinn; Boeing, Heiner; Brandstedt, Jenn ...; Boutron-Ruault, ...; Chirlaque, Maria ...; Dorronsoro, Mire ...; Dossus, Laure; Duell, Eric J.; Gram, Inger T.; Gunter, Marc; Hansen, Louise; Idahl, Annika, 1 ...; Johnson, Theron; Khaw, Kay Tee; Krogh, Vittorio; Kvaskoff, Marina; Mattiello, Amali ...; Matullo, Giusepp ...; Merritt, Melissa ...; Nodin, Bjorn; Orfanos, Philipp ...; Onland-Moret, N. ...; Palli, Domenico; Peppa, Eleni; Quiros, J. Ramon; Sanchez-Perez, M ...; Severi, Gianluca; Tjønneland, Anne; Travis, Ruth C.; Trichopoulou, An ...; Tumino, Rosario; Weiderpass, Elis ...; Fortner, Renee T ...; Kaaks, Rudolf; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

Artiklar i publikationen: Cancer Epidemiol ...

Av lärosätet: Lunds universitet; Umeå universitet; Karolinska Institutet

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Anti-CA15.3 and Anti-CA125 Antibodies and ovarian cancer risk : Results from the EPIC cohort

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